Publications

Chartier M, Desgagné M, Sousbie M, Côté J, Longpré JM, Marsault E, Sarret P.
Design, Structural Optimization, and Characterization of the First Selective Macrocyclic Neurotensin Receptor Type 2 Non-opioid Analgesic.
J Med Chem. 2021 Feb 4.

Merlet AN, Harnie J, Macovei M, Doelman A, Gaudreault N, Frigon A.
Cutaneous inputs from perineal region facilitate spinal locomotor activity and modulate cutaneous reflexes from the foot in spinal cats.
J Neurosci Res. 2021 Feb 1.

Trân K, Van Den Hauwe R, Sainsily X, Couvineau P, Côté J, Simard L, Echevarria M, Murza A, Serre A, Théroux L, Saibi S, Haroune L, Longpré JM, Lesur O, Auger-Messier M, Spino C, Bouvier M, Sarret P, Ballet S, Marsault É.
Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile.
J Med Chem. 2021 Feb 1.

Beauchesne W, Savard C, Côté-Hamel M, Poliquin É, Gagné-Ouellet V, Gagnon C, Tremblay K. 
Characterization of cannabis use by patients with myotonic dystrophy type 1: A pilot study.
Neuromuscul Disord. 2021 Jan 9:S0960-8966(21)00004-3.

Gagnon M, Savard M, Jacques JF, Bkaily G, Geha S, Roucou X, Gobeil F.
Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.
J Biol Chem. 2021 Jan 23:100329.

Trân K, Murza A, Sainsily X, Delile E, Couvineau P, Côté J, Coquerel D, Peloquin M, Auger-Messier M, Bouvier M, Lesur O, Sarret P, Marsault É.
Structure-Activity Relationship and Bioactivity of Short Analogues of ELABELA as Agonists of the Apelin Receptor.
J Med Chem. 2021 Jan 14;64(1):602-615.

Ryczko D, Hanini-Daoud M, Condamine S, Bréant BJB, Fougère M, Araya R, Kolta A.
S100β-mediated astroglial control of firing and input processing in layer 5 pyramidal neurons of the mouse visual cortex.
J Physiol. 2021 Jan;599(2):677-707.

Knüsel J, Crespi A, Cabelguen JM, Ijspeert AJ, Ryczko D. 
Reproducing Five Motor Behaviors in a Salamander Robot With Virtual Muscles and a Distributed CPG Controller Regulated by Drive Signals and Proprioceptive Feedback.
Front Neurorobot. 2020 Dec 23;14:604426.

Al-Otaibi M, Lessard-Beaudoin M, Castellano CA, Gris D, Cunnane SC, Graham RK.
Volumetric MRI demonstrates atrophy of the olfactory cortex in AD.
Curr Alzheimer Res. 2020;17(10):904-915.

Sadybekov AA, Brouillette RL, Marin E, Sadybekov AV, Luginina A, Gusach A, Mishin A, Besserer-Offroy É, Longpré JM, Borshchevskiy V, Cherezov V, Sarret P, Katritch V.
Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR.
Biomolecules. 2020 Dec 3;10(12):1634.

Avet C, Sturino C, Grastilleur S, Gouill CL, Semache M, Gross F, Gendron L, Bennani Y, Mancini JA, Sayegh CE, Bouvier M.
The PAR2 inhibitor I-287 selectively targets Gαq and Gα12/13 signaling and has anti-inflammatory effects.
Commun Biol. 2020 Nov 27;3(1):719.

Harnie J, Audet J, Klishko AN, Doelman A, Prilutsky BI, Frigon A.
The spinal control of backward locomotion.
J Neurosci. 2020 Nov 24:JN-RM-0816-20.

Flaive A, Fougère M, van der Zouwen CI, Ryczko D.
Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals.
Front Neural Circuits. 2020 Nov 5;14:590299.

Gagnon AL, Lavoie A, Frigon MP, Michaud-Herbst A, Tremblay K.
A Drug-Induced Acute Pancreatitis Retrospective Study.
Can J Gastroenterol Hepatol. 2020 Nov 3;2020:1516493.

Latash EM, Lecomte CG, Danner SM, Frigon A, Rybak IA, Molkov YI.
On the Organization of the Locomotor CPG: Insights From Split-Belt Locomotion and Mathematical Modeling.
Front Neurosci. 2020 Oct 16;14:598888.

Vincent L, Lapointe C, Lo M, Gagnon H, Pejler G, Takai S, Day R, D'Orleans-Juste P.
Mast cell degranulation increases mouse Mast Cell Protease 4-dependent vasopressor responses to big endothelin-1 but not Angiotensin I.
J Pharmacol Exp Ther. 2020 Nov 5:JPET-AR-2020-000325.

D'Orléans-Juste P, Lapointe C.
The Fifth Tomoh Masaki Award (2019).
Can J Physiol Pharmacol. 2020 Sep;98(9):xiii-xiv.

Nunes MA, Toricelli M, Schöwe NM, Malerba HN, Dong-Creste KE, Farah DMAT, De Angelis K, Irigoyen MC, Gobeil F, Araujo Viel T, Buck HS.
Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer's Disease Pathological Characteristics in a Transgenic Mouse Model.
Pharmaceuticals (Basel). 2020 Oct 1;13(10):288.

Ryczko D, Simon A, Ijspeert AJ.
Walking with Salamanders: From Molecules to Biorobotics.
Trends Neurosci. 2020 Nov;43(11):916-930.

Sikpa D, Whittingstall L, Savard M, Lebel R, Côté J, McManus S, Chemtob S, Fortin D, Lepage M, Gobeil F.
Pharmacological Modulation of Blood-Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions.
Pharmaceuticals (Basel). 2020 Sep 29;13(10):279.

Ryczko D, Grätsch S, Alpert MH, Cone JJ, Kasemir J, Ruthe A, Beauséjour PA, Auclair F, Roitman MF, Alford S, Dubuc R.
Descending Dopaminergic Inputs to Reticulospinal Neurons Promote Locomotor Movements.
J Neurosci. 2020 Oct 28;40(44):8478-8490.

Gonzalez S, Dumitrascuta M, Eiselt E, Louis S, Kunze L, Blasiol A, Vivancos M, Previti S, Dewolf E, Martin C, Tourwé D, Cavelier F, Gendron L, Sarret P, Spetea M, Ballet S.
Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies.
J Med Chem. 2020 Nov 12;63(21):12929-12941.

Zerif E, Khan FU, Raki AA, Lullier V, Gris D, Dupuis G, Amrani A.
Elucidating the Role of Ezh2 in Tolerogenic Function of NOD Bone Marrow-Derived Dendritic Cells Expressing Constitutively Active Stat5b.
Int J Mol Sci. 2020 Sep 4;21(18):6453.

Murza A, Dion SP, Boudreault PL, Désilets A, Leduc R, Marsault É.
Inhibitors of type II transmembrane serine proteases in the treatment of diseases of the respiratory tract - A review of patent literature.
Expert Opin Ther Pat. 2020 Nov;30(11):807-824.

Fougère M, van der Zouwen CI, Boutin J, Ryczko D.
Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8-A13.
J Comp Neurol. 2020 Sep 1.

Tremblay K, Brisson D, Gaudet D.
Gene expression profiles of recurrent acute pancreatitis risk in patients with sustained chylomicronemia.
Endocr J. 2020 Nov 28;67(11):1157-1161.

Besserer-Offroy É, Tétreault P, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent A, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P.
Data set describing the in vitro biological activity of JMV2009, a novel silylated neurotensin(8-13) analog.
Data Brief. 2020 Jun 20;31:105884.

Previti S, Vivancos M, Rémond E, Beaulieu S, Longpré JM, Ballet S, Sarret P, Cavelier F.
Insightful Backbone Modifications Preventing Proteolytic Degradation of Neurotensin Analogs Improve NTS1-Induced Protective Hypothermia.
Front Chem. 2020 Jun 5;8:406.

Lanchec E, Désilets A, Béliveau F, Fontaine-Carbonneau C, Laniel A, Leduc R, Lavoie C.
Matriptase processing of APLP1 ectodomain alters its homodimerization.
Sci Rep. 2020 Jun 22;10(1):10091.

Tétreault P, Besserer-Offroy É, Brouillette RL, René A, Murza A, Fanelli R, Kirby K, Parent AJ, Dubuc I, Beaudet N, Côté J, Longpré JM, Martinez J, Cavelier F, Sarret P.
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog.
Eur J Pharmacol. 2020 Sep 5;882:173174.

Degrandmaison J, Abdallah K, Blais V, Génier S, Lalumière MP, Bergeron F, Cahill CM, Boulter J, Lavoie CL, Parent JL, Gendron L.
In vivo mapping of a GPCR interactome using knockin mice.
Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):13105-13116.

Le Roux A, Blaise É, Boudreault PL, Comeau C, Doucet A, Giarrusso M, Collin MP, Neubauer T, Kölling F, Göller AH, Seep L, Tshitenge DT, Wittwer M, Kullmann M, Hillisch A, Mittendorf J, Marsault E.
Structure-Permeability Relationship of Semipeptidic Macrocycles-Understanding and Optimizing Passive Permeability and Efflux Ratio.
J Med Chem. 2020 Jul 9;63(13):6774-6783.

Laroche M, Lessard-Beaudoin M, Garcia-Miralles M, Kreidy C, Peachey E, Leavitt BR, Pouladi MA, Graham RK.
Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model.
Hum Mol Genet. 2020 Aug 3;29(13):2134-2147.

Langlois JP, Millette G, Guay I, Dubé-Duquette A, Chamberland S, Jacques PÉ, Rodrigue S, Bouarab K, Marsault É, Malouin F.
Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus.
Front Microbiol. 2020 May 5;11:805.

Quirion B, Bergeron F, Blais V, Gendron L.
The Delta-Opioid Receptor; a Target for the Treatment of Pain.
Front Mol Neurosci. 2020 May 5;13:52.

Girard M, Dagenais Bellefeuille S, Eiselt É, Brouillette R, Placet M, Arguin G, Longpré JM, Sarret P, Gendron FP.
The P2Y6 receptor signals through Gaq /Ca2+ /PKCa and Ga13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration.
J Cell Physiol. 2020 May 18. doi: 10.1002/jcp.29779. Online ahead of print.

Flaive A, Cabelguen JM, Ryczko D.
The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HT1A receptors.
J Neurophysiol. 2020 Jun 1;123(6):2326-2342.

Zhu T, Gobeil F, Vazquez-Tello A, Leduc M, Rihakova L, Bossolasco M, Bkaily G, Peri K, Varma DR, Orvoine R, Chemtob S.
Correction: Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors.
Can J Physiol Pharmacol. 2020 Jun;98(6):413.

Constanzo J, Midavaine É, Fouquet J, Lepage M, Descoteaux M, Kirby K, Tremblay L, Masson-Côté L, Geha S, Longpré JM, Paquette B, Sarret P.
Brain irradiation leads to persistent neuroinflammation and long-term neurocognitive dysfunction in a region-specific manner.
Prog Neuropsychopharmacol Biol Psychiatry. 2020 Aug 30;102:109954.

Eiselt É, Otis V, Belleville K, Yang G, Larocque A, Régina A, Demeule M, Sarret P, Gendron L.
Use of a Noninvasive Brain-Penetrating Peptide-Drug Conjugate Strategy to Improve the Delivery of Opioid Pain Relief Medications to the Brain.
J Pharmacol Exp Ther. 2020 Jul;374(1):52-61.

van der Zouwen CI, Ryczko D.
Motor Control: Swim Harder, Faster, Stronger.
Curr Biol. 2020 Apr 6;30(7):1356.

Poret B, Desrues L, Bonin MA, Pédard M, Dubois M, Leduc R, Modzelewski R, Decazes P, Morin F, Vera P, Castel H, Bohn P, Gandolfo P.
Development of Novel 111-In-Labelled DOTA Urotensin II Analogues for Targeting the UT Receptor Overexpressed in Solid Tumours.
Biomolecules. 2020 Mar 19;10(3):471.

Berthiaume S, Abdallah K, Blais V, Gendron L.
Alleviating pain with delta opioid receptor agonists: evidence from experimental models.
J Neural Transm (Vienna). 2020 Apr;127(4):661-672.

van der Zouwen CI, Ryczko D.
Motor Control: Swim Harder, Faster, Stronger.
Curr Biol. 2020 Mar 9;30(5):R229-R232.

Brouillette RL, Besserer-Offroy É, Mona CE, Chartier M, Lavenus S, Sousbie M, Belleville K, Longpré JM, Marsault É, Grandbois M, Sarret P.
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain.
Pharmacol Res. 2020 May;155:104750.

Ahuie GK, Gagnon H, Pace PE, Peskin AV, Wagner RJ, Naylor S, Klarskov K.
Investigating protein thiol chemistry associated with dehydroascorbate, homocysteine and glutathione using mass spectrometry.
Rapid Commun Mass Spectrom. 2020 Jun 15;34(11):e8774.

Barrière DA, Midavaine É, Doré-Savard L, Kirby K, Tremblay L, Beaudoin JF, Beaudet N, Longpré JM, Lecomte R, Lepage M, Sarret P.
Publisher Correction: Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management.
Sci Rep. 2020 Feb 14;10(1):2979.

Merlet AN, Harnie J, Macovei M, Doelman A, Gaudreault N, Frigon A.
Mechanically stimulating the lumbar region inhibits locomotor-like activity and increases the gain of cutaneous reflexes from the paws in spinal cats.
J Neurophysiol. 2020 Feb 12.

Gagnon AL, Frigon MP, Tremblay K.
Hospitalizations for Acute and Chronic Pancreatitis in a French-Canadian Population.
Pancreas. 2020 Jan;49(1):e3-e5.

Audet M, Villers K, Velasquez J, Chu M, Hanson C, Stevens RC.
Small-scale approach for precrystallization screening in GPCR X-ray crystallography.
Nat Protoc. 2020 Jan;15(1):144-160.

André Barrière D, Midavaine É, Doré-Savard L, Kirby K, Tremblay L, Beaudoin JF, Beaudet N, Longpré JM, Lecomte R, Lepage M, Sarret P.
Dichotomic effects of clinically used drugs on tumor growth, bone remodeling and pain management.
Sci Rep. 2019 Dec 27;9(1):20155.

Harnie J, Doelman A, de Vette E, Audet J, Desrochers E, Gaudreault N, Frigon A.
The recovery of standing and locomotion after spinal cord injury does not require task-specific training.
Elife. 2019 Dec 11;8.

Gusach A, Luginina A, Marin E, Brouillette RL, Besserer-Offroy É, Longpré JM, Ishchenko A, Popov P, Patel N, Fujimoto T, Maruyama T, Stauch B, Ergasheva M, Romanovskaia D, Stepko A, Kovalev K, Shevtsov M, Gordeliy V, Han GW, Katritch V, Borshchevskiy V, Sarret P, Mishin A, Cherezov V.
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.
Nat Commun. 2019 Dec 6;10(1):5573.

Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Müller CE, Stevens RC.
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.
Sci Adv. 2019 Nov 27;5(11)

Awwad F, Bertrand G, Grandbois M, Beaudoin N.
Auxin protects Arabidopsis thaliana cell suspension cultures from programmed cell death induced by the cellulose biosynthesis inhibitors thaxtomin A and isoxaben.
BMC Plant Biol. 2019 Nov 21;19(1):512.

Barrière DA, Boumezbeur F, Dalman R, Cadeddu R, Richard D, Pinguet J, Daulhac L, Sarret P, Whittingstall K, Keller M, Mériaux S, Eschalier A, Mallet C.
Acetaminophen, a centrally-acting analgesic involving the periaqueductal grey.
Br J Pharmacol. 2019 Nov 16.

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators.
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors.
Br J Pharmacol. 2019 Dec;176 Suppl 1(Suppl 1):S21-S141.

Luginina A, Gusach A, Marin E, Mishin A, Brouillette R, Popov P, Shiriaeva A, Besserer-Offroy É, Longpré JM, Lyapina E, Ishchenko A, Patel N, Polovinkin V, Safronova N, Bogorodskiy A, Edelweiss E, Hu H, Weierstall U, Liu W, Batyuk A, Gordeliy V, Han GW, Sarret P, Katritch V, Borshchevskiy V, Cherezov V.
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv. 2019 Oct 9;5(10)

Eiselt E, Gonzalez S, Martin C, Chartier M, Betti C, Longpré JM, Cavelier F, Tourwé D, Gendron L, Ballet S,Sarret P.
Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and Hypothermia.
ACS Chem Neurosci. 2019 Nov 20;10(11):4535-4544.

Desroches A, Denault JB.
Caspase-7 uses RNA to enhance proteolysis of poly(ADP-ribose) polymerase 1 and other RNA-binding proteins.
Proc Natl Acad Sci U S A. 2019 Oct 4.

Boulkeroua C, Ayari H, Khalfaoui T, Lafrance M, Besserer-Offroy É, Ekindi N, Sabbagh R, Dumaine R, Lesur O, Sarret P, Chraibi A.
Apelin-13 Regulates Vasopressin-Induced Aquaporin-2 Expression and Trafficking in Kidney Collecting Duct Cells.
Cell Physiol Biochem. 2019;53(4):687-700.

Binda C, Génier S, Degrandmaison J, Picard S, Fréchette L, Jean S, Marsault E, Parent JL.
L-type prostaglandin D synthase regulates the trafficking of the PGD2 DP1 receptor by interacting with the GTPase Rab4.
J Biol Chem. 2019 Oct 1.

Béliveau F, Tarkar A, Dion SP, Désilets A, Ghinet MG, Boudreault PL, St-Georges C, Marsault É, Paone D, Collins J, Macphee CH, Campobasso N, Groy A, Cottom J, Ouellette M, Pope AJ, Leduc R.
Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.
Cell Chem Biol. 2019 Sep 17.

Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Smith MD, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Calabresi PA, Amrani A, Gris D.
NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.
PLoS Biol. 2019 Sep 16;17(9):e3000451.

Awwad F, Bertrand G, Grandbois M, Beaudoin N.
Reactive Oxygen Species Alleviate Cell Death Induced by Thaxtomin A in Arabidopsis thaliana Cell Cultures.
Plants (Basel). 2019 Sep 6;8(9).

Gendron L, Nagi K, Zeghal M, Giguère PM, Pineyro G.
Molecular aspects of delta opioid receptors.
Vitam Horm. 2019;111:49-90.

Simmons JR, Murza A, Lumsden MD, Kenward C, Marsault É, Rainey JK.
Simultaneous Ligand and Receptor Tracking through NMR Spectroscopy Enabled by Distinct 19F Labels.
Int J Mol Sci. 2019 Jul 26;20(15).

Connolly A, Holleran BJ, Simard É, Baillargeon JP, Lavigne P, Leduc R.
Interplay between intracellular loop 1 and helix VIII of the angiotensin II type 2 receptor controls its activation.
Biochem Pharmacol. 2019 Oct;168:330-338.

Park H, Latash EM, Molkov YI, Klishko AN, Frigon A, DeWeerth SP, Prilutsky BI.
Cutaneous sensory feedback from paw pads affects lateral balance control during split-belt locomotion in the cat.
J Exp Biol. 2019 Jul 26;222(Pt 14).

Banville FA, Moreau J, Chabot K, Cattoni A, Fröhlich U, Bryche JF, Collin S, Charette PG, Grandbois M, Canva M.
Nanoplasmonics-enhanced label-free imaging of endothelial cell monolayer integrity.
Biosens Bioelectron. 2019 Sep 15;141:111478.

Desbiens L, Lapointe C, Gendron L, Gharagozloo M, Vincent L, Pejler G, Gris D, D'Orléans-Juste P.
Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1.
J Pharmacol Exp Ther. 2019 Sep;370(3):437-446.

Marsault E, Llorens-Cortes C, Iturrioz X, Chun HJ, Lesur O, Oudit GY, Auger-Messier M.
The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders.
Ann N Y Acad Sci. 2019 Jun 25.

Ahuié Kouakou G, Gagnon H, Lacasse V, Wagner JR, Naylor S, Klarskov K.
Dehydroascorbic acid S-Thiolation of peptides and proteins: Role of homocysteine and glutathione.
Free Radic Biol Med. 2019 Sep;141:233-243.

Jafari L, Savard M, Gobeil F, Langelier E.
Characterization of moderate tendinopathy in ex vivo stress-deprived rat tail tendons.
Biomed Eng Online. 2019 May 8;18(1):54.

Mahmoud S, Gharagozloo M, Simard C, Amrani A, Gris D.
NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes.
Cells. 2019 Apr 30;8(5):400.

Jafari L, Hassanisaber H, Savard M, Gobeil F Jr, Langelier E.
Efficacy of Combining PRP and MMP Inhibitors in Treating Moderately Damaged Tendons Ex Vivo.
J Orthop Res. 2019 May 1.

Li X, Rosciglione S, Laniel A, Lavoie C.
Combining RNAi and Immunofluorescence Approaches to Investigate Post-endocytic Sorting of GPCRs into Multivesicular Bodies.
Methods Mol Biol. 2019;1947:303-322.

Génier S, Degrandmaison J, Lavoie CL, Gendron L, Parent JL.
Monitoring the Aggregation of GPCRs by Fluorescence Microscopy.
Methods Mol Biol. 2019;1947:289-302.

Malette J, Degrandmaison J, Giguère H, Berthiaume J, Frappier M, Parent JL, Auger-Messier M, Boulay G.
MURC/CAVIN-4 facilitates store-operated calcium entry in neonatal cardiomyocytes.
Biochim Biophys Acta Mol Cell Res. 2019 Aug;1866(8):1249-1259.

Biet M, Ton AT, Delabre JF, Morin N, Dumaine R.
In utero exposure to nicotine abolishes the postnatal response of the cardiac sodium current to isoproterenol in newborn rabbit atrium.
Heart Rhythm. 2019 Apr;16(4):494-501.

Bentzinger CF.
Best supporting actors.
Science. 2019 Mar 8;363(6431):1051.

Mahmoud S, Gharagozloo M, Simard C, Gris D.
Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release.
Cells. 2019 Feb 20;8(2):184.

Lessard-Beaudoin M, Yu-Taeger L, Laroche M, Singer E, Riess O, Nguyen HHP, Graham RK.
Olfactory bulb atrophy and caspase activation observed in the BACHD rat models of Huntington disease.
Neurobiol Dis. 2019 May;125:219-231.

Eiselt E, Côté J, Longpré JM, Blais V, Sarret P, Gendron L.
The combination of opioid and neurotensin receptor agonists improves their analgesic/adverse effect ratio.
Eur J Pharmacol. 2019 Apr 5;848:80-87.

Lukjanenko L, Karaz S, Stuelsatz P, Gurriaran-Rodriguez U, Michaud J, Dammone G, Sizzano F, Mashinchian O, Ancel S, Migliavacca E, Liot S, Jacot G, Metairon S, Raymond F, Descombes P, Palini A, Chazaud B, Rudnicki MA, Bentzinger CF, Feige JN.
Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors.
Cell Stem Cell. 2019 Mar 7;24(3):433-446.e7.

Beaudeau JL, Blais V, Holleran BJ, Bergeron A, Piñeyro G, Guérin B, Gendron L, Dory YL.
N-Guanidyl and C-Tetrazole Leu-Enkephalin Derivatives: Efficient Mu and Delta Opioid Receptor Agonists with Improved Pharmacological Properties.
ACS Chem Neurosci. 2019 Mar 20;10(3):1615-1626.

Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA.
Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.
Sci Signal. 2018 Dec 4;11(559).

Marsault É.
[A novel class of polycationic macromolecules against multiresistant pathogens].
Med Sci (Paris). 2018 Oct;34(10):791-795.

Brodeur N, Cloutier P, Bass AD, Bertrand G, Hunting DJ, Grandbois M, Sanche L.
Absolute cross section for DNA damage induced by low-energy (10 eV) electrons: Experimental refinements and sample characterization by AFM.
J Chem Phys. 2018 Oct 28;149(16):164904.

Lemieux MJ, Denault JB, Overall CM.
Highlight: Frontiers in Proteolysis.
Biol Chem. 2018 Oct 26.

Desrochers E, Harnie J, Doelman A, Hurteau MF, Frigon A.
Spinal control of muscle synergies for adult mammalian locomotion.
J Physiol. 2018 Oct 18.

Hurteau MF, Frigon A.
A spinal mechanism related to left-right symmetry reduces cutaneous reflex modulation independent of speed during split-belt locomotion.
J Neurosci. 2018 Oct 12.

Söllradl T, Chabot K, Fröhlich U, Canva M, Charette PG, Grandbois M.
Monitoring individual cell-signaling activity using combined metal-clad waveguide and surface-enhanced fluorescence imaging.
Analyst. 2018 Nov 5;143(22):5559-5567.

D'Orléans-Juste P, Akide Ndunge OB, Desbiens L, Tanowitz HB, Desruisseaux MS.
Endothelins in inflammatory neurological diseases.
Pharmacol Ther. 2019 Feb;194:145-160.

Normandeau CP, Torruella Suárez ML, Sarret P, McElligott ZA, Dumont EC.
Neurotensin and dynorphin Bi-Directionally modulate CeA inhibition of oval BNST neurons in male mice.
Neuropharmacology. 2018 Sep 21;143:113-121.

Houde M, Schwertani A, Touil H, Desbiens L, Sarrhini O, Lecomte R, Lepage M, Gagnon H, Takai S, Pejler G, Jacques D, Gobeil F Jr, Day R, D'Orléans-Juste P.
Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction.
Front Pharmacol. 2018 Aug 31;9:868.

Willemse T, Eiselt E, Hollanders K, Schepens W, van Vlijmen HWT, Chung NN, Blais V, Holleran B, Longpré JM, Schiller PW, Maes BUW, Sarret P, Gendron L, Ballet S.
Corrigendum to Chemical space screening around Phe3 in opioid peptides: Modulating µ versus d agonism by Suzuki-Miyaura cross-couplings [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323].
Bioorg Med Chem Lett. 2018 Nov 1;28(20):3418.

Dion SP, Béliveau F, Morency LP, Désilets A, Najmanovich R, Leduc R.
Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell lines.
Sci Rep. 2018 Aug 22;8(1):12562.

Dubuc C, Savard M, Bovenzi V, Lessard A, Côté J, Neugebauer W, Geha S, Chemtob S, Gobeil F Jr.
Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.
J Cell Physiol. 2018 Aug 21.

Tutunea-Fatan E, Abd-Elrahman KS, Thibodeau JF, Holterman CE, Holleran BJ, Leduc R, Kennedy CRJ, Gros R, Ferguson SSG.
GRK2 knockdown in mice exacerbates kidney injury and alters renal mechanisms of blood pressure regulation.
Sci Rep. 2018 Jul 30;8(1):11415.

Sousbie M, Vivancos M, Brouillette RL, Besserer-Offroy É, Longpré JM, Leduc R, Sarret P, Marsault É.
Structural Optimization and Characterization of Potent Analgesic Macrocyclic Analogues of Neurotensin 8-13.
J Med Chem. 2018 Jul 23.

Tan BY, Wang L, Uttamchandani M, Barajas-Martinez H, Dumaine R, Morin N, Ching CK, Ho KL, Chong DTT, Chow W, Yap EPH, Moochhala S, Hu D, Yong RYY, Teo WS.
A novel three base-pair deletion in domain two of the cardiac sodium channel causes Brugada syndrome.
Electrocardiol. 2018 Jul - Aug;51(4):667-673.

Lavenus S, Simard É, Besserer-Offroy É, Froehlich U, Leduc R, Grandbois M.
Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses.
Pharmacol Res. 2018 Jun 27.

Bonato L, Taleb N, Gingras V, Messier V, Gobeil F, Ménard J, Ardilouze JL, Rabasa-Lhoret R.
Duration of Catheter Use in Patients with Diabetes Using Continuous Subcutaneous Insulin Infusion: A Review.
Diabetes Technol Ther. 2018 Jul;20(7):506-515.

Fougère M, Ryczko D.
[A descending dopaminergic pathway to control movement].
Med Sci (Paris). 2018 May;34(5):386-388.

Harnie J, Côté-Sarrazin C, Hurteau MF, Desrochers E, Doelman A, Amhis N, Frigon A.
The modulation of locomotor speed is maintained following partial denervation of ankle extensors in spinal cats.
J Neurophysiol. 2018 Jun 13.

Willemse T, Eiselt E, Hollanders K, Schepens W, van Vlijmen HWT, Chung NN, Blais V, Holleran B, Longpré JM, Schiller PW, Maes BUW, Sarret P, Gendron L, Ballet S.
Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.
Bioorg Med Chem Lett. 2018 Jul 15;28(13):2320-2323.

Klarskov K, Gagnon H, Racine M, Boudreault PL, Normandin C, Marsault E, Gleich GJ, Naylor S.
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome.
Toxicol Lett. 2018 Sep 15;294:193-204.

Hassan GS, Jacques D, D'Orléans-Juste P, Magder S, Bkaily G.
Physical contact between human vascular endothelial and smooth muscle cells modulates cytosolic and nuclear calcium homeostasis.
Can J Physiol Pharmacol. 2018 Jul;96(7):655-661.

Abdallah K, Nadeau F, Bergeron F, Blouin S, Blais V, Bradbury KM, Lavoie CL, Parent JL, Gendron L.
Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents.
Sci Rep. 2018 May 9;8(1):7321.

St-Pierre D, Cabana J, Holleran BJ, Besserer-Offroy É, Escher E, Guillemette G, Lavigne P, Leduc R.
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms.
Biochem Pharmacol. 2018 Apr 20.

Henry MS, Bisht K, Vernoux N, Gendron L, Torres-Berrio A, Drolet G, Tremblay MÈ.
Delta Opioid Receptor Signaling Promotes Resilience to Stress Under the Repeated Social Defeat Paradigm in Mice.
Front Mol Neurosci. 2018 Apr 6;11:100.

Maurice-Gélinas C, Deslauriers J, Monpays C, Sarret P, Grignon S.
The 5a-reductase inhibitor finasteride increases suicide-related aggressive behaviors and blocks clozapine-induced beneficial effects in an animal model of schizophrenia.
Physiol Behav. 2018 Apr 7;191:65-72.

Lamontagne Boulet M, Isabelle C, Guay I, Brouillette E, Langlois JP, Jacques PÉ, Rodrigue S, Brzezinski R, Beauregard PB, Bouarab K, Boyapelly K, Boudreault PL, Marsault É, Malouin F.
Tomatidine, a lead antibiotic molecule that targets Staphylococcus aureus ATP synthase subunit C.
Antimicrob Agents Chemother. 2018 Apr 2.

Hurteau MF, Thibaudier Y, Dambreville C, Danner SM, Rybak I, Frigon A.
Intralimb and interlimb cutaneous reflexes during locomotion in the intact cat.
J Neurosci. 2018 Mar 21.

Sousbie M, Besserer-Offroy É, Brouillette RL, Longpré JM, Leduc R, Sarret P, Marsault É.
In Search of the Optimal Macrocyclization Site for Neurotensin.
ACS Med Chem Lett. 2018 Jan 29;9(3):227-232.

Besserer-Offroy É, Bérubé P, Côté J, Murza A, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Marsault É, Sarret P.
The hypotensive effect of activated apelin receptor is correlated with ß-arrestin recruitment.
Pharmacol Res. 2018 Mar 9;131:7-16.

Söllradl T, Banville FA, Chabot V, Canva M, Grandbois M, Charette PG.
Metal clad waveguide (MCWG) based imaging using a high numerical aperture microscope objective.
Opt Express. 2017 Feb 6;25(3):1666-1679.

Dubuc C, Savard M, Bovenzi V, Lessard A, Fortier A, Côté J, Neugebauer W, Rizzolio F, Geha S, Giordano A, Chemtob S, Gobeil F.
Targeting intracellular B2 receptors using novel cell-penetrating antagonists to arrest growth and induce apoptosis in human triple-negative breast cancer.
Oncotarget. 2018 Jan 5;9(11):9885-9906.

Trân K, Murza A, Sainsily X, Coquerel D, Côté J, Belleville K, Haroune L, Longpré JM, Dumaine R, Salvail D, Lesur O, Auger-Messier M, Sarret P, Marsault É.
A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects.
J Med Chem. 2018 Mar 22;61(6):2266-2277.

Dion SP, Béliveau F, Désilets A, Ghinet MG, Leduc R.
Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities.
J Cell Mol Med. 2018 Feb 14.

Guay I, Boulanger S, Isabelle C, Brouillette E, Chagnon F, Bouarab K, Marsault E, Malouin F.
Tomatidine and analog FC04-100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp.
BMC Pharmacol Toxicol. 2018 Feb 13;19(1):7.

Constanzo J, Dumont M, Lebel R, Tremblay L, Whittingstall K, Masson-Côté L, Geha S, Sarret P, Lepage M, Paquette B, Descoteaux M.
Diffusion MRI Monitoring of Specific Structures in the Irradiated Rat Brain.
Magn Reson Med. 2018 Feb 9.

Coquerel D, Sainsily X, Dumont L, Sarret P, Marsault É, Auger-Messier M, Lesur O.
The apelinergic system as an alternative to catecholamines in low-output septic shock.
Crit Care. 2018 Jan 19;22(1):10.

Barrière DA, Noll C, Roussy G, Lizotte F, Kessai A, Kirby K, Belleville K, Beaudet N, Longpré JM, Carpentier AC, Geraldes P, Sarret P.
Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications.
Sci Rep. 2018 Jan 11;8(1):424.

Yan LH, Le Roux A, Boyapelly K, Lamontagne AM, Archambault MA, Picard-Jean F, Lalonde-Seguin D, St-Pierre E, Najmanovich RJ, Fortier LC, Lafontaine D, Marsault É.
Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.
Eur J Med Chem. 2018 Jan 1;143:755-768.