Épisode 42: ÉTUDE COLCORONA

Diffusé le 15 juin 2021

Dans cette 42e baladodiffusion, le Dr Luc Lanthier discute de de l’efficacité et l’innocuité de la colchicine comme traitement des sujets ambulatoires atteints de la COVID-19, en plus de réviser la littérature médicale de mai 2021.

Quiz clinique (4 min 06), étude principale (4 min 27), critique (22 min 00), autres articles (33 min 25), réponse au quiz clinique (36 min 18)

Syllabus de la présentation

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Tardif J-C, Bouabdallaoui N, L'Allier PL, Gaudet D, Shah B, Pillinger MH, et al. Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial. Lancet Respir Med. 2021;9(8):924-32. PubMed PMID : 34051877.

Deftereos SG, Giannopoulos G, Vrachatis DA, Siasos GD, Giotaki SG, Gargalianos P, et al. Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019: The GRECCO-19 Randomized Clinical Trial. JAMA Netw Open. 2020;3(6):e2013136. PubMed PMID: 32579195.

Lopes MI, Bonjorno LP, Giannini MC, Amaral NB, Menezes PI, Dib SM, et al. Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial. RMD Open. 2021;7(1). Epub 2021/02/06. doi: 10.1136/rmdopen-2020-001455. PubMed PMID: 33542047.

Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, Abbass H, et al. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. Lancet. 2021;397(10289):2049-59. PubMed PMID: 34000257.

Haas EJ, Angulo FJ, McLaughlin JM, Anis E, Singer SR, Khan F, et al. Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. Lancet. 2021;397(10287):1819-29. PubMed PMID: 33964222.

https://bestpractice.bmj.com/topics/en-gb/3000201/emergingtxs

https://covid-nma.com

https://www.covid-trials.org

Bauersachs RM, Szarek M, Brodmann M, Gudz I, Debus ES, Nehler MR, et al. Total Ischemic Event Reduction with Rivaroxaban after Peripheral Arterial Revascularization in the VOYAGER PAD Trial. J Am Coll Cardiol. 2021. Epub 2021/05/20. doi: 10.1016/j.jacc.2021.05.003. PubMed PMID: 34010631.

Adler A, Agodoa L, Algra A, Asselbergs FW, Beckett NS, Berge E, et al. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. Lancet. 2021;397(10285):1625-36. PubMed PMID: 33933205.

Dorman SE, Nahid P, Kurbatova EV, Phillips PPJ, Bryant K, Dooley KE, et al. Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis. N Engl J Med. 2021;384(18):1705-18. PubMed PMID: 33951360.

SPRINT Research Group, Lewis CE, Fine LJ, Beddhu S, et al. Final Report of a Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med. 2021;384(20):1921-1930. PubMed PMID: 34010531.

Jones WS, Mulder H, Wruck LM, et al; ADAPTABLE Team. Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. N Engl J Med. 2021;384(21):1981-1990. PubMed PMID: 33999548.

USPSTF, Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, et al. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;325(19):1965-77. PubMed PMID: 34003218.

Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR, Practice Parameters Committee of the American College of G. ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. Am J Gastroenterol. 2021;116(5):878-98. PubMed PMID: 33929376.

Laine L, Barkun AN, Saltzman JR, Martel M, Leontiadis GI. ACG Clinical Guideline: Upper Gastrointestinal and Ulcer Bleeding. Am J Gastroenterol. 2021;116(5):899-917. PubMed PMID: 33929377.

Nuzzo R. Scientific method: statistical errors. Nature. 2014 Feb 13;506(7487):150-2. PMID: 24522584.

Wasserstein RL, Lazar NA. The ASA Statement on p-Values: Context, Process, and Purpose. The American Statistician. 2016;70(2):129-33. doi: 10.1080/00031305.2016.1154108.

Ioannidis JPA. The Proposal to Lower P Value Thresholds to .005. JAMA. 2018;319(14):1429-30. PubMed PMID: 29566133.

Wasserstein RL, Schirm AL, Lazar NA. Moving to a World Beyond “p < 0.05”. The American Statistician. 2019;73(sup1):1-19. doi: 10.1080/00031305.2019.1583913.

Benjamin DJ, Berger JO. Three Recommendations for Improving the Use of p-Values. The American Statistician. 2019;73(sup1):186-91. doi: 10.1080/00031305.2018.1543135.

Vidéo du Dr Anand Senthi : https://youtu.be/HYfwC0PhqJs

Vidéo du Dr Mark Tonelli : https://youtu.be/IPgrn2ACWuI

Vidéo du Dr John Ioannidis : https://youtu.be/N63skNtYaJw

Altman DG, Bland JM. Absence of evidence is not evidence of absence. BMJ. 1995;311(7003):485. PubMed PMID: 7647644.

http://bedside-rounds.org/episode-25-salt-water/

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