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Ahmed Chraïbi

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie

Présentation

Sujet de recherche

Électrophysiologie, Hypertension artérielle, Mutation (processus), Système rénal

Disciplines de recherche

Biologie moléculaire, Physiologie

Mots-clés

ENaC, patch-clamp, voltage-clamp, mutagénèse, sous clonage, selfinhibition, hyertention

Intérêts de recherche

Étude des relations structure, fonction et régulation du canal sodique épithélial (ENaC)

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(2003). (Post-doctorat, Premier assistant). Université de Lausanne.

(1999). (Post-doctorat, Assistant dipômé). Université de Lausanne.

(1995). (Doctorat, Doctorat de l'Université de Paris V).

(1992). (Equivalent à la maîtrise, Diplôme des Études Approfondies). Université de Paris VII (Denis Diderot).

(1989). (Diplôme, Maîtrise de Physiologie Animale - Maîtrise). Université de Paris XI (Paris-Sud).

(1987). (Equivalent au baccalauréat, Licence). Université de Paris XI (Paris-Sud).

Titres de compétence

Professeur agrégé.

Publications

Articles de revue

  • (2014). Functionalup-regulation of Nav1.8 sodium channel in Aβ afferent fibers subjected to chronic peripheralinflammation. J Neuroinflammation 11 (45), 1742-2094.
  • (2014). PPARγ-induced stimulation of amiloride-sensitive sodium current in renal collecting duct principal cellsis serum and insulin dependent. Cell Physiol Biochem. 33 (3), 581-93.
  • Belkouch M, Dansereau MA, Réaux-Le Goazigo A, Van Steenwinckel J, Beaudet N, Chraibi A*, Melik-Parsadaniantz S*, Sarret P* *: contributed equally to this work. (2011). The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a Gβγ-dependent mechanism. Journal of Neuroscience 31
  • S. Renauld, K. Tremblay, M. Simoneau-Roy, S. Ait-Benichou and A. Chraïbi. (2010). Stimulation of ENaC activity by rosiglitazone is PPARγ-dependent and correlates with SGK1 expression increase. Journal of. Membrane Biology 236
  • O. Lesur, JF Roussy, F. Chagnon, NG Payet, R. Dumaine, P. Sarret, A. Chraibi, L. Chouinard, B Hogue. (2010). Proven infection-related sepsis induces a differential stress response early after ICU admission. Critical Care 14
  • A. Goolaert, J. Roux, M. Ganter, V. Shlyonsky, A. Chraibi, S. Renauld, F. Mies, M. Matthay, R. Naeije, S. Sariban-Sohraby, M. Howard and J.F. Pittet. (2010). Serotonin Decreases Alveolar Epithelial Fluid Transport via a Direct Inhibition of ENaC. American Journal of Respiratory Cell and Molecular Biology 43
  • Chamberland C., Barajas-Martinez H., Haufe V., Fecteau MH., Delabre JF., Lesur O. , Chraibi A., Sarret P. and Dumaine R. (2010). Modulation of canine cardiac sodium current by Apelin. Journal of Molecular and Cellular Cardiology 48
  • S. Renauld and A. Chraïbi,. (2009). Role of the C-Terminal Part of the Extracellular Domain of the α-ENaC in Activation by Sulfonyl-urea glibenclamide. Journal of Membrane Biology 230
  • S. Renauld, R, Allache and A. Chraibi. (2008). Ile-481 from the Guinea-Pig α-subunit plays a major role in the activation of ENaC by cpt-cAMP. Cellular Physiology and Biochemistry 22
  • Wildman S., Marks J., Churchill L., Peppiatt C., Chraibi A., Shirley D., Horisberger JD, King B and R.Unwin. (2005). Regulatory interdependence of cloned epithelial Na+ channels and P2X receptors. Journal of the American Society of Nephrology 16
  • J.-D. Horisberger and A. Chraïbi. (2004). Epithelial sodium channel : A Ligand-Gated Channel ?. Nephron Physiology 96
  • A. Chraïbi and J.-D. Horisberger,. (2003). Dual effect of temperature on the human Epithelial Na+ Channel. Pfulgers archive 447
  • A. Chraïbi and J.-D. Horisberger. (2002). Na+ Self-inhibition of human Epithelial sodium Channel: Temperature dependence and effect of extracellular proteases. J.Gen. Physiol. 120
  • C. Debonneville, S.Y. Flores, E. Kamynina, P.J. Plant, C. Tauxe, M.A. Thomas, C. Münster, A. Chraïbi H. Pratt, J-D Horisberger, D. Pearce, J. Loffing and O. Staub. (2001). Phosphorylation of Nedd4-2 by SGK1 regulates epithelial Na+ channel cell surface expression. EMBO 24
  • A. Chraïbi, M. Schnizler, W. Clauss, J.-D. Horisberger. (2001). Effects of 8-cpt-cAMP on the epithelial sodium channel expressed in Xenopus oocytes. J. Membr. Biol. 183
  • A. Chraïbi, C. Verdumo, A.-M. Merillat, B.C. Rossier, J.-D. Horisberger, E. Hummler. (2001). Functional analysis of a N-terminal splice variant of the alpha subunit of the epithelial sodium channel. Cell. Physiol. Biochem. 11
  • O. Bonny, A. Chraïbi, J. Loffing, N. Fowler Jaeger , S. Gründer, J.-D. Horisberger, B.C. Rossier. (1999). Functional expression of a pseudohypoaldosteronism type I mutated epithelial Na+ channel lacking the pore-forming region of it’s alpha subunit. J. Clin. Invest. 104
  • A. Chraïbi, J.-D. Horisberger. (1999). Stimulation of epithelial sodium channel activity by the sulfonylurea glibenlamide. J.Pharmacol. Exp. Ther. 290
  • Chraïbi A, Vallet V, Firsov D, Hess SK, Horisberger JD. (1998). Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocyte. J. Gen. Physiol. 111
  • V. Vallet, A. Chraïbi, H.-P. Gaeggeler, J.-D. Horisberger and B.C. Rossier. (1997). An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature . , 1997. 389 : 607-610 389
  • Chraïbi A, Guinamard R, Teulon J. (1995). Effects of internal pH on the nonselective cation channel from the mouse collecting tubule. Journal of Membrane Biology 148
  • Guinamard R, Chraïbi A, Teulon J. (1995). A small-conductance Cl- channel in the mouse thick ascending limb that is activated by ATP and protein kinase A. Journal of Physiology 1995 May 15 485
  • Chraïbi A, Van den Abbeele T, Guinamard R, Teulon J. (1994). A ubiquitous non-selective cation channel in the mouse renal tubule with variable sensitivity to calcium. Pflugers Archive 429

Chapitres de livre

  • A. Chraibi and S. Renauld. (2013). New Insights into the Epithelial Sodium Channel Using Directed Mutagenesis. GENETIC MANIPULATION OF DNA AND PROTEIN – EXAMPLES FROM CURRENT RESEARCH (221-232). David Figurski, ISBN 978-953-51-0994-5. (Article publié).