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Yves Bérubé-Lauzière

Professeur, Faculté de génie
FAC. GÉNIE Électrique et informatique

Présentation

Sujet de recherche

Imagery, Modelization and Simulation, Optics and Photonics, Vision, X-Rays

Disciplines de recherche

Biomedical Engineering and Biochemical Engineering, Physical Engineering

Mots-clés

Applied mathematics, Biomedical imaging, Biomedical optics, Diffuse optical tomography, Inverse problems, In vivo fluorescence, Molecular imaging, Optical instrumentation, Time-resolved optical measurements

Intérêts de recherche

My research interests concentrate on the development of diffuse optical tomographic reconstruction algorithms for applications in fluorescence molecular imaging on small animals, along with the development of instrumentation to realize scanners for these applications.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français, Allemand, Italien

Diplômes

(2002). (Doctorate, Philosophiae Doctor (Ph.D.)). McGill University.

(1993). (Master's Thesis, Master's Degree in Science (M.Sc.) - Masters). Université de Montréal.

(1991). (Bachelor's, Bachelor's Degree in Science (B.Sc.)). Université de Montréal.

Publications

Articles de revue

  • Edjlali E, Bérubé-Lauzière Y. (2015). Analytical solution of the simplifed spherical harmonics equations in spherical turbid media. Journal of Quantitative Spectroscopy and Radiative Transfer (Submitted).
  • Bérubé-Lauzière Y, Crotti* M, Boucher* S, Ettehadi* S, Pichette* J, Rech I. (2015). Prospects on time-domain diffuse optical tomography based on time-correlated single photon counting for small animal molecular imaging. Journal of Spectroscopy (Submitted).
  • Kanoun* M, Ben Attouch* M, Bérubé-Lauzière Y, Fontaine R. (2014). A 10-bit, 12 ps resolution CMOS time-to-digital converter dedicated to ultra-fast optical timing applications. Circuits, Systems & Signal Processing 34 1129-1148. (Published).
  • Spinelli L, Botwicz M, Zolek N, Kacprzak M, Milej D, Liebert A, Weigel U, Durduran T, Foschum F, Kienle A, Baribeau F, Leclair S, Bouchard JP, Noiseux I, Gallant P, Mermut O, Pifferi A, Torricelli A, Cubeddu R, Ho H-C, Mazurenka M, Wabnitz H, Klauenberg K, Olha B, Elster C, Bénazech-Lavoué* M, Bérubé-Lauzière Y, Lesage F, Khoptyar D, Subash A A, Di Ninni P, Martelli F, Zaccanti G. (2014). Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink. Biomedical Optics Express 5 (7), 2037--2053. (Published).
  • Pichette* J, Boucher* S, Bouza Domínguez G, Bérubé-Lauzière Y. (2014). Diffuse photon density wavefront speed as a contrast for tomographic imaging of heterogeneous diffusive media. Optics Letters 39 (7), 2097-2100. (Published).
  • Ranyuk* E, Lebel R, Bérubé-Lauzière Y, Klarskov K, Lecomte R, van Lier J E, Guérin B. (2013). 68Ga/DOTA-and 64Cu/NOTA-Phthalocyanine Conjugates as Fluorescent/PET Bimodal Imaging Probes. Bioconjugate Chemistry 24 (9), 1624-1633. (Published).
  • Pichette* J, Bouza Domínguez J, Bérubé-Lauzière Y. (2013). Time-domain geometrical localization of point-like fluorescence inclusions in turbid media with early photon arrival times. Applied Optics (Selected for publication in the Virtual Journal for Biomedical Optics 8(9), 2013) 52 (24), 5985-5999. (Published).
  • Di Ninni P, Bérubé-Lauzière Y, Mercatelli L, Sani E, Martelli F. (2012). Fat emulsions as diffusive reference standards for tissue simulating phantoms?. Applied Optics 51 (30), 7176-7182. (Published).
  • Lapointe* E, Pichette* J, Bérubé-Lauzière Y. (2012). A multi-view time-domain non-contact diffuse optical tomography scanner with dual wavelength detection for intrinsic and fluorescence small animal imaging. Review of Scientific Instruments (Selected for publication in the Virtual Journal of Biological Physics Research 23(12), 2012) 83 (6), 063703. (Published).
  • Bouza Domínguez* J, Bérubé-Lauzière Y. (2012). Light propagation from fluorescent probes in biological tissues by coupled time-dependent parabolic simplified spherical harmonics equations. Biomedical Optics Express 2 (4), 817-837. (Published).
  • Bouza Domínguez* J, Bérubé-Lauzière Y. (2012). Diffuse optical tomographic imaging of biological media by time-dependent parabolic SPN equations: a two-dimensional study. Journal of Biomedical Optics 17 (8), 0860121-08601214. (Published).
  • Bouza Domínguez* J, Bérubé-Lauzière Y. (2010). Diffuse light propagation in biological media by a time-domain parabolic simplified spherical harmonics approximation with ray divergence effects. Applied Optics (Selected for publication in the Virtual Journal for Biomedical Optics 5(7), 2010) 49 (8), 1414-1429. (Published).

Chapitres de livre

  • Bouza Domínguez* J, Bérubé-Lauzière Y. (2013). 6. Radiative transfer and optical imaging in biological media by low-order transport approximations: the simplified spherical polynomials (SPN) approach. Light Scattering Reviews 8 (8, 269-315). Springer/Praxis Publishing Ltd. (Published).

Articles de conférence

  • Edjlali E, Bérubé-Lauzière Y. (2015). Analytical solution of the simplified spherical harmonics equations for spherical media. Diffuse Optical Imaging V - European Conferences on Biomedical Optics. (Published).
  • Kanoun* M, Bérubé-Lauzière Y, Fontaine R. (2014). A 10-bit, 3 ps precision time-to-digital converter for diffuse optical tomography measurements. 21st IEEE International Conference on Electronics Circuits and Systems (ICECS2014). (Accepted).
  • Provencher D, Bartels A, Bérubé-Lauzière Y, Whittingstall K. (2014). Hemodynamic response function estimation in the visual cortex during sinusoidal visual stimuli. 20th Annual Meeting of the Organization for Human Brain Mapping (OHBM) 2014. (Accepted).
  • Zarif Yussefian* N, Letendre-Jauniaux M, Sikpa* D, Lebel R, Ducharme M-E, Daigle O, Bérubé-Lauzière Y. (2014). Continuous wave optical scanner for small animal molecular imaging. Biomedical Optics Topical Meeting (OSA-BIOMED). BM3A-55. (Published).
  • Pichette* J, Bérubé-Lauzière Y. (2014). Imaging diffuse photon density wavefront speeds with early photons arrival times. Biomedical Optics Topical Meeting (OSA-BIOMED). BM3A-62. (Published).
  • Bouza Domínguez J, Bérubé-Lauzière Y. (2013). Three-dimensional diffuse optical tomography with full multi-view time-domain data. Proc. SPIE 8578, 8578-83. (Published).
  • Lebel R, Zarifyussefian* N, Letendre-Jauniaux M, Daigle O, Ranyuk* E, van Lier J, Guérin B, Lecomte R, Massonneau M, Ducharme M-E, Bérubé-Lauzière Y. (2013). Ultra-high sensitivity detection of bimodal probes at ultra-low noise for combined fluorescence and positron emission tomography imaging. Proc. SPIE 8574, 85740M 1–7. (Published).
  • Smeesters C, Bérubé-Lauzière Y, Rancourt D, Langelier E, Balg F, Fontaine F. (2012). Problem- and project-based learning in bioengineering : a case study. 36th Annual Meeting of the American Society of Biomechanics. (Published).
  • Bouza Domínguez* J, Bérubé-Lauzière Y. (2012). Tomographic reconstruction of absorption and diffusion coefficient maps in biological media using time-dependent parabolic simplified spherical harmonics equations. Biomedical Optics Topical Meeting (OSA-BIOMED) (Optical Society of America). (Published).
  • Spinelli L, Botwicz M, Zolek N, Kacprzak M, Milej D, Liebert A, Weigel U, Durduran T, Foschum F, Kienle A, Baribeau F, Leclair S, Bouchard J-P, Noiseux I, Gallant P, Mermut O, Pifferi A, Torricelli A, Cubeddu R, Ho H.-C., Mazurenka M, Wabnitz H, Klauenberg K, Olha B, Elster C, Bénazech-Lavoué* M, Bérubé-Lauzière Y, Lesage F, Khoptyar D, Subash A. A., Di Ninni P, Martelli F, Zaccanti G. (2012). Inter-laboratory comparison of optical properties performed on Intralipid and India Ink. Biomedical Optics Topical Meeting (OSA-BIOMED). BW1A--6. (Published).
  • Di Ninni P, Bérubé-Lauzière Y, Martelli F. (2012). Possible diffusive reference standards for tissue phantoms based on fat emulsions. Proc. SPIE 8229, (Published).
  • Bouza Domínguez* J, Bérubé-Lauzière Y. (2011). Diffuse optical tomography of absorption in biological media using time-dependent parabolic simplified spherical harmonics equations. Proc. SPIE 8088, (Published).
  • Bérubé-Lauzière Y, Lapointe E. (2010). A time-domain non-contact fluorescence diffuse optical tomography scanner for small animal imaging. Biomedical Optics Topical Meeting (OSA-BIOMED). BTuD76. (Published).
  • Bouza Domínguez* J, Bérubé-Lauzière Y. (2010). Light propagation in biological media by time-domain parabolic SPN equations with ray divergence effects. Biomedical Optics Topical Meeting (OSA-BIOMED) (Optical Society of America). BME1. (Published).
  • Pichette* J, Bérubé-Lauzière Y. (2010). Time-domain elliptical localization of point-like fluorescence inclusions with early photons arrival times. Biomedical Optics TopicalMeeting (OSA-BIOMED) (Optical Society of America). BTuD46. (Published).
  • Bodi G, Bérubé-Lauzière Y. (2009). Spatial localization of discrete fluorescent inclusions with early photons: an analysis on the stability with respect to variations of optical properties. Proc. SPIE 7386, 73860H--73860H. (Published).
  • Bodi G, Bérubé-Lauzière Y. (2009). A new deconvolution technique for time-domain signals in diffuse optical tomography without a priori information. Proc. SPIE 7369, (Published).
  • Desrochers J, Vermette P, Fontaine R, Bérubé-Lauzière Y. (2009). Reconstruction of thin fluorophore-filled capillaries in thick scattering medium using fluorescence diffuse optical tomography within the diffusion approximation. Proc. SPIE 7179, 71790I-71790I. (Published).
  • Bérubé-Lauzière Y, Issa* V, Bouza Domínguez* J. (2009). Simplified spherical harmonics approximation of the time-dependent equation of radiative transfer for the forward problem in time-domain diffuse optical tomography. Proc. SPIE 7174, (Published).
  • Pichette* J, Lapointe* E, Bérubé-Lauzière Y. (2009). Three-dimensional localization of discrete fluorescent inclusions from multiple tomographic projections in the time-domain. Proc. SPIE 7174, (Published).
  • Kanoun* M, Bérubé-Lauzière Y, Fontaine R. (2008). High precision time-to-amplitude converter for diffuse optical tomography applications. IEEE Int’l Conf. on Design and Test of Integrated Systems in Nanoscale Era (DTIS ’08). (Published).
  • Bioud* F-Z, Bérubé-Lauzière Y. (2008). Fabrication and characterization of optical phantoms. Proc. SPIE 7099, (Published).
  • Desrochers* J, Vermette P, Fontaine R, Bérubé-Lauzière Y. (2008). Three-dimensional spatial localization of thin fluorophore-filled capillaries in thick scattering media. Proc. SPIE 7099, (Published).
  • Pichette* J, Lapointe* E, Bérubé-Lauzière Y. (2008). Time-domain 3D localization of fluorescent inclusions in a thick scattering medium. Proc. SPIE 7099, 709907-709907. (Published).
  • Robichaud V, Bérubé-Lauzière Y. (2008). Time-domain spatial localization of fluorescent inclusions in thick scattering media with early photons. Biomedical Optics Topical Meeting (OSA-BIOMED). BMD32. (Published).

Propriétés intellectuelles

Patents

  • (2012). System for the detection of dental artefacts. US Pat. 8,297,971. (Completed).
  • (2011). System and method for detection of dental tartar. US Pat. 7,862,335. (Completed).
  • (2008). Method and apparatus for selecting regions of interest in optical imaging. US Pat. 7,366,333. (Completed).
  • (2006). Method and apparatus for time resolved optical imaging of biological tissues as part of animal. US Pat. 6,992,762. (Completed).

Autres contributions

Activités de collaboration internationale

  • Participant in an international study. Participated in an international multi-laboratory study on the characterization of biological tissue mimicking turbid media as part of the nEUROPt project funded by the European 7th Framework Programme and led by the Biomedical Optics Group at Politecnico di Milano, Milan, Italy. We carried out measuremnts according to a standardized protocol, provided our results and wrote part of a research article which was recently published in Biomedical Optics Express.