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François Michel Boisvert

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. d'immunologie et de biologie cellulaire

Présentation

Sujet de recherche

Cancer of the Digestive System, Cell Signaling and Cancer, Genomic Damage and Repair, Proteins, Proteomics

Disciplines de recherche

Biochemistry, Cell Biology

Mots-clés

Biochemistry, Cell Biology, DNA Repair, Mass Spectrometry, Microscopy, Molecular Biology, Nuclear Structures, Nucleus, Transcription, Ubiquitylation

Intérêts de recherche

focus of my research careerThe is to study the regulatory mechanisms of DNA repair and replicationthrough a cross-disciplinary expertise integrating biochemistry, cell biology and proteomics approaches.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(2011). Protein Analysis of Protein Localization Following DNA Damage. (Post-doctorate, Postdoctoral Fellow). University of Dundee.

(2005). A Role for Arginine Methylation in DNA Repair (Doctorate, Ph.D.). McGill University.

(2000). Characterization of PML Nuclear Bodies (Master's Thesis, M.Sc. - Masters). The University of Calgary.

(1998). (Bachelor's, B.Sc.). Université de Montréal.

Expérience académique

Full Professor/Professeur Titulaire. (2021-). Université de Sherbrooke. Canada.

Director - Cancer Research Institute of the Université de Sherbrooke. (2021-). Université de Sherbrooke. Canada.

Director - Proteomics Facility of the Université de Sherbrooke. (2012-). Université de Sherbrooke. Canada.

Associate Professor/Professeur Agrégé. (2016-2021). Université de Sherbrooke. Canada.

Director - Cell Biology MSc/PhD Programs. (2019-2021). Université de Sherbrooke. Canada.

Assistant Professor/Professeur Adjoint. (2011-2016). Université de Sherbrooke. Canada.

Post-Doctoral Fellow. (2005-2011). University of Dundee. United Kingdom.

Ph.D. Student. (2000-2005). McGill University. Canada.

M.Sc. Student. (1998-2000). The University of Calgary. Canada.

Prix et distinctions

  • (2024) Research Scholars - FRQS Senior. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2020) Research Scholars - FRQS Junior 2. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2016) Research Scholars - Junior 1 Career salary Award. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2009) Post Doctoral Fellowship. The Royal Society of Edinburgh Foundation. (Prize / Award).
  • (2006) Post-Doctoral Fellowship. Canadian Institutes of Health Research. (Prize / Award).
  • Prix de la recherche et de la création 2021. Université de Sherbrooke. (Prize / Award).
  • Young Investigator Award. Canadian Association of Gastroenterology. (Prize / Award).

Financement

  • Grant. (Awarded). Principal Applicant. Urine biomarkers for bladder cancer diagnosis and surveillance: a multicentric study to assess the diagnostic accuracy of a comprehensive diagnostic tool.. European Commission (The). Joint Translational Calls for collaborative innovative research projects in Personalised Medicine.. 835 281 $. (2023-2025)
  • Grant. (Awarded). Principal Applicant. Urinary proteomics: towards the discovery of biomarkers for the early diagnosis of bladder cancer. Canadian Cancer Society. Challenge Grants. 448 808 $. (2022-2024)
  • Scholarship. (Awarded). Principal Applicant. FRQ-S Senior Salary Award. Fonds de recherche du Québec - Santé (FRQS). Chercheurs-Boursiers - Sénior. 260 595 $. (2020-2024)
  • Grant. (Completed). Principal Applicant. Assembly and function of DNA double-strand break repair foci.. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grants Program - Individual. 252 000 $. (2018-2024)
  • Grant. (Completed). Principal Applicant. Ubiquitin-KEKS: Function of a Novel Ubiquitin Isoform Coded by UBBP4, a Gene Initially Annotated as a Pseudogene.. Canadian Institutes of Health Research (CIHR). Project Grant - Fall 2017 and Spring 2018. 891 225 $. (2018-2023)
  • Grant. (Completed). Collaborator. Measuring baseline ascorbic acid levels in the optimal vasopressor titration trian (HECHT ID #4410). Lotte & John Hecht Memorial Foundation. InspireHealth Funding Program. 206 800 $. (2018-2020)
  • Grant. (Completed). Co-applicant. URINE PROTEOMICS: Towards the discovery of potent biomarkers for early diagnosis of bladder cancer.. Merck Sharp & Dohme Research Laboratory. Programme de Subvention Merck/UdeS. 67 000 $. (2018-2020)
  • Scholarship. (Completed). Principal Applicant. FRQ-S Junior 2 Salary Award. Fonds de recherche du Québec - Santé (FRQS). Junior 2 Scholarships. 295 448 $. (2016-2020)
  • Grant. (Completed). Co-applicant. Impact de la délétion génétique intestin-spécifique de HNF4A (MODY1) sur le métabolisme lipidique.. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). PAFI 2018-2019. 25 000 $. (2018-2019)
  • Grant. (Completed). Principal Applicant. Ubiquitination of the MCM-ASF1 complex by DDB1-CUL4 following DNA damage.. Cancer Research Society (The). 2017 Cancer Research Society Competition. 120 000 $. (2017-2019)
  • Grant. (Completed). Principal Applicant. Precision medicine: a mass spectrometer for the discovery of new protein biomarkers in cancer and diseases.. Canada Foundation for Innovation (CFI). John R. Evans Leaders Fund. 1 589 998 $. (2018-2019)
  • Grant. (Completed). Principal Investigator. A mass spectrometer for the establishment of a proteomics facility at the Université de Sherbrooke. (2012-2017)
  • Grant. (Completed). Principal Applicant. Discovery of prognostic biomarkers for the implementation of personalized treatments for patients with colorectal cancer.. (2015-2017)
  • Grant. (Completed). Principal Investigator. Proteomic Analysis of Human Intestinal Cells. (2012-2017)
  • Grant. (Completed). Principal Investigator. Identification of the DDB1/CUL4 associated factors ubiquitination targets. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Institutional Bridge Funding. 40 000 $. (2016-2016)
  • Scholarship. (Completed). Principal Applicant. Étude protéomique de la réponse cellulaire aux agents causant des dommages à l'ADN dans le cancer colorectal.. (2012-2016)
  • Grant. (Completed). Principal Investigator. Subcellular redistribution of proteins following DNA damage: a role for the MCM complex in DNA repair.. (2012-2015)
  • Grant. (Completed). Principal Applicant. Étude protéomique de la réponse cellulaire aux agents causant des dommages à l'ADN dans le cancer colorectal.. (2012-2015)
  • Grant. (Completed). Principal Applicant. Soins personnalisés pour les patients avec un cancer du rectum traités par la radiochimiothérapie néoadjuvante à l’aide de biomarqueurs pronostiques. (2014-2015)
  • Grant. (Completed). Co-applicant. Étude protéomique du complexe NIC1 dans le contexte inflammatoire du cancer pancréatique.. (2013-2014)
  • Grant. (Completed). Co-applicant. Étude protéomique du complexe NIC1 dans le contexte inflammatoire du cancer pancréatique. (2012-2013)
  • Contract. (Completed). Principal Investigator. Proteomic Analysis of the Cellular Response to DNA Damage. (2011-2013)
  • Grant. (Completed). Principal Investigator. Subcellular Redistribution of Proteins Following DNA Damage: A Role for the MCM-ASF1 Complex in DNA Repair. (2012-2012)

Publications

Articles de revue

  • *Shajari, E., Gagné, D., Malick, M., Roy, P., Noël, J.-F., Gagnon, H., Brunet, M.A., Delisle, M., Boisvert, F.-M. and Beaulieu, J.-F. (2024). Application of SWATH Mass Spectrometry and Machine Learning in the Diagnosis of Inflammatory Bowel Disease Based on the Stool Proteome. Biomedicines 12 (2), 333. (Published).
  • Shukla, A., Khan, M.G.M, Cayarga, A.A., Namvarpour, M., Chowdhury, M.M.H., Lévesque, D., Lucier, J.-F., Boisvert, F.-M., Ramanathan, s. and Ilangumaran, S. (2024). The Tumor Suppressor SOCS1 Diminishes Tolerance to Oxidative Stress in Hepatocellular Carcinoma. Cancers (Basel) 16 (2), 292. (Published).
  • Gall-Duncan, T., Luo, J., *Jurkovic, C.-M., Fischer, L.A., Fujita, K., Leib, D.E., Li, V., Harding, R.J., Tran, S., Chen, R., Tanaka, H., Deshmukh, A.L., Mason, A.G., Lévesque, D., Khan, M., Lanni, S., Sato, N., Caron, M.-C., Masson, J.-Y., Panigrahi, G.B., Prasolava, T., Lau, R., La Spada, A.R., Campos, E.I., Curtis, M.A., Boisvert, F.-M., Faull, R.L.M., Davidson, B.L., Wold, M.S., Okazawa, H., Pearson, C.E. (2023). Antagonistic roles of canonical and alternative RPA in tandem CAG repeat diseases. Cell 23 01030-9. (Published).
  • *Frion, J., *Meller, A., *Marbach, G., Lévesque, D., Roucou, X., Boisvert, F.-M. (2023). CRISPR/Cas9-mediated knockout ofthe ubiquitin variant UbKEKS reveals a role in regulating nucleolar structuresand composition. Biology Open bio.059984 1. (Published).
  • Khatir, I., Brunet, M.A., *Meller, A., Amiot, F., Patel, T., Lopez, J.A., Guilloy, N., Castonguay, A., Husain, M.A., St-Germain, J., Boisvert, F.-M., Plourde, M., Roucou, X. and Laurent, B. (2023). Decoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets. Cells 12 (4), 615. (Published).
  • Farah Lizott, Marina Roussea, Benoit Denhe, Andréanne Guay, Sarah Higgins, Robert Sabbagh, François-Michel Boisvert, Anne Marie Côté and Pedro Geraldes. (2023). Deletion of SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease. Kidney International S0085-2538(23) (10), 1. (Published).
  • Jurkovic, C.-M. and Boisvert, F.-M. (2023). Evolution of techniques and tools for replication fork proteome and protein interaction studies. Biochemistry & Cell Biology 10.1139 0215. (Published).
  • Pomerleau, V., Nicolas, V.R., *Jurkovic, C.-M., Faucheux, N., Lauzon, M-A., Boisvert, F.-M., Perreault, N. (2023). FoxL1+ Telocytes in mouse colon orchestrate ECM biodynamics and wound repair resolution. Journal of Proteomics 271 (104755), 1. (Published).
  • Pulido, J.A.H., Boisvert, F.-M., Boudreau, F. (2023). Hepatocyte nuclear factor 4a multiple isoforms, their functions, and their interactomes. Proteomics 10 (1002), 1. (Published).
  • Cleopatra Rutihinda, Ryma Haroun, Nour Elhouda Saidi, Juan Pablo Ordoñez, Sahar Naasri, Dominique Lévesque, François-Michel Boisvert, Pierre-Hugues Fortier, Mathieu Belzile, Laurent Fradet, Vincent Hubert-Tremblay, Guy Anne Turgeon, Chang Shu Wang, Patrick Delage, Étienne Rousseau, Benoît Paquette, Ayman J Oweida. (2023). Inhibition of the CCR6-CCL20 axis prevents regulatory T cell recruitment and sensitizes head and neck squamous cell carcinoma to radiation therapy. Cancer Immunol Immunother 72 (5), 1089-1102. (Published).
  • Luda, K.M., Goosen, S.K., Ma, E.H., Watson, M.J., Duimstra, L.R., Oswald, B.M., Longo, J., Fu, Z., Madaj, Z., Kupai, A., Dickson, B.M., Kaymak, I., Compton, S., DeCamp, L.M., Kelly, D.P., Puchalska, P., Williams, K.S., Krawczyk, C.M., Boisvert, F.-M., Sheldon, R.D., Rothbart, S.B., Crawford, P.A., Jones, R.G. (2023). Ketolysis drives CD8+ T cell effector function through effect on histone acetylation. Immunity S1074-7613 (23), 1. (Published).
  • *Raisch, J., *Dubois, M.-L., Groleau, M., Lévesque, D., *Jurkovic, C.-M., *McKenna, A., *Barrette, C., Jacques, P.-É., Boisvert, F.-M. (2023). Pulse-SILAC and interactomics reveal distinct DDB1-CUL4 associated factors (DCAFs), cellular functions, and protein substrates. Molecular & Cellular Proteomics 22 (10), 1. (Published).
  • Gonneaud, A., Asselin, C., Giroux, V., Boisvert, F.-M. (2023). Workflow for Quantitative Proteomic Analysis of Intestinal Organoids Using SILAC. Methods Mol Biol. 2603 151-161. (Published).
  • O’Sullivan, Julia; Kothari, Charu; Caron, Marie; Gagné, Jean-Philippe; Jin, Zhigang; Nonfoux, Louis; Coulombe, Yan; Milano de Souza , Larissa; Beneyton, Adèle; Atalay, Nurgul; Jean, Dominique; Boisvert, François-Michel; Hendzel, Michael; Masson, Jean-Yves; Poirier, Guy. (2023). ZNF432 stimulates PARylation and inhibits DNA resection to balance PARPi sensitivity and resistance. Nucleic Acids Research 12 791. (Published).
  • Jean-François Lemay, Edlie St-Hilaire, Daryl A Ronato, Yuandi Gao, François Bélanger, Sari Gezzar-Dandashi, Aimé Boris Kimenyi Ishimwe, Christina Sawchyn, Dominique Lévesque, Mary McQuaid, François-Michel Boisvert, Frédérick A Mallette, Jean-Yves Masson, Elliot A Drobetsky, Hugo Wurtele. (2022). A genome-wide screen identifies SCAI as a modulator of the UV-induced replicative stress response. PLoS Biology 20 (10), 1371. (Published).
  • Alain B Alfonso, Véronique Pomerleau, Vilcy Reyes Nicolás, Jennifer Raisch, Carla-Marie Jurkovic, François-Michel Boisvert#, Nathalie Perreault# Co-corresponding authors. (2022). Comprehensive Profiling of Early Neoplastic Gastric Microenvironment Modifications and Biodynamics in Impaired BMP-Signaling FoxL1+-Telocytes. Biomedecines 11 (1), 1-19. (Published).
  • *Chauvin, A., Bergeron, D., Vencic, J., Lévesque, D., Paquette, B., Scott, M.S. and Boisvert, F.-M. (2022). Downregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cells. BMC Cancer 22 (1), 363. (Published).
  • McQuaid M.E., Ahmed K., Tran S., Rousseau J., Shaheen R., Kernohan K.D., Yuki K.E., Grover P., Dreseris E.S., Ahmed S., Dupuis L., Stimec J., Shago M., Al-Hassnan Z.N., Tremblay R., Maass P.G., Wilson M.D., Grunebaum E., Boycott K.M., Boisvert F.-M., Maddirevula S., Faqeih E.A., Almanjomi F., Khan Z.U., Alkuraya F.S., Campeau P.M., Kannu P., Campos E.I., Wurtele H. (2022). Hypomorphic GINS3 variants alter DNA replicationand cause Meier-Gorlin syndrome. JCI Insight 7 (10), 155648. (Published).
  • Becker, Y.-L., Gagné, J.P., Julien, A.S., Lévesque, T., Allaeys, I., Gougeard, N., Rubio, V., Boisvert, F.-M., Jean, D., Wagner, E., Poirier, G.G., Fortin P.R. and Boilard, É. (2022). Identification of mitofusin 1 and complement component 1q subcomponent-binding protein as mitochondrial targets in systemic lupus erythematosus. Arthritis Rheumatol. 10 1002. (Published).
  • Cleopatra Rutihinda, Ryma Haroun, Nour Elhouda Saidi, Juan Pablo Ordoñez, Sahar Naasri, Dominique Lévesque, François-Michel Boisvert, Pierre-Hugues Fortier, Mathieu Belzile, Laurent Fradet, Vincent Hubert-Tremblay, Guy Anne Turgeon, Chang Shu Wang, Patrick Delage, Étienne Rousseau, Benoît Paquette, Ayman J Oweida. (2022). Inhibition of the CCR6-CCL20 axis prevents regulatory T cell recruitment and sensitizes head and neck squamous cell carcinoma to radiation therapy. Cancer Immunol Immunother. 10 (1007), 1. (Published).
  • Meller, A*., Boisvert, F.-M. (2022). Mining Proteomics Datasets to Uncover Functional Pseudogenes. Methods Mol Biol. 2456 241-251. (Published).
  • *Santharam, M.A., Shukla, A., Levesque, D., Kufer, T.A., Boisvert, F.-M., Ramanathan, S. and Ilangumaran, S. (2022). NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity. Int J Mol Sci 24 (8), 7206. (Published).
  • David Gagné, *Elmira Shajari, Marie-Pier Thibault, Jean-François Noël, François-Michel Boisvert, Corentin Babakissa, Emile Levy, Hugo Gagnon, Marie A Brunet, David Grynspan, Emanuela Ferretti, Valérie Bertelle, Jean-François Beaulieu. (2022). Proteomics Profiling of Stool Samples from Preterm Neonates with SWATH/DIA Mass Spectrometry for Predicting Necrotizing Enterocolitis. Int J Mol Sci. 23 (19), 1. (Published).
  • Nassari, S., Lacarrière-Keïta, C., Lévesque, D., Boisvert, F.-M. and Jean S. (2022). Rab21 in enterocytes participates in intestinal epithelium maintenance. Molecular Biology of the Cell doi: 10.1091 (mbcE210301), E21-03-0139. (Published).
  • Dahabieh, M.S., Goncalves, C., Khoury, E., Bolt, A., Mann, K.K., Xu, Z.Y. Boisvert, F.-M., Miller Jr., W.H. and del Rincon, S.V. (2022). Silencing PEX26 as anunconventional mode to killdrug-resistant cancer cells forestall drug resistance. Autophagy 21 1-19. (Published).
  • Gonneaud, A., Turgeon, N., Boisvert, F.-M., Boudreau, F., Asselin, C. (2021). JAK-STAT Pathway Inhibition Partially Restores Intestinal Homeostasis in Hdac1- and Hdac2- Intestinal Epithelial Cell-Deficient Mice. Cells 10 (2), 224. (Published).
  • Brunet, Marie; Lucier, Jean-François; Levesque, Maxime; Leblanc, Sébastien; Jacques, Jean-François; Al-Saedi, Hasan; Guilloy, Noé; Grenier, Frederic; Avino, Mariano; Fournier, Isabelle; Salzet, Michel; Ouangraoua, Aida; Scott, Michelle; Boisvert, François-Michel; Roucou, Xavier. (2021). OpenProt 2021: deeper functional annotation ofthe coding potential of eukaryotic genomes. Nucleic Acids Research 49 (D1), 380-388. (Published).
  • Rosalind F Roberts , Andrew N Bayne, Thomas Goiran, Dominique Lévesque, François-Michel Boisvert, Jean-François Trempe, Edward A Fon. (2021). Proteomic Profiling of Mitochondrial-Derived Vesicles in Brain Reveals Enrichment of Respiratory Complex Sub-assemblies and Small TIM Chaperones. Journal of Proteome Research 20 (1), 506-517. (Published).
  • *Madanraj Appiya Santharam, Akhil Shukla, Awais Ullah Ihsan, Maryse Cloutier, Dominique Lévesque, Sheela Ramanathan, François-Michel Boisvert and Subburaj Ilangumaran. (2021). SILAC proteomics implicates SOCS1 in modulating cellular macromolecular complexes and the ubiquitin conjugating enzyme UBE2D involved in MET receptor tyrosine kinase downregulation. Biochimie 182 185-196. (Published).
  • *Lambert, É., Babeu, J.-P., Simoneau, J., *Raisch, J., *Lévesque, D., *Jolibois, É., Avino, M., Scott, M., Boudreau, F. and Boisvert, F.-M. (2020). Human Hepatocyte Nuclear Factor 4-alpha encodes isoforms with distinct transcriptional functions. Molecular & Cellular Proteomics 19 (5), 808-827. (Published).
  • Marie-Hélène Masse, Marie-Claude Battista, Mary Elizabeth Wilcox, Ruxandra Pinto, Nicole Marinoff, Frédérick D'Aragon, Charles St-Arnaud, Michael Mayette, Marc-André Leclair, Hector Quiroz Martinez, Brian Grondin-Beaudoin, Yannick Poulin, Élaine Carbonneau, Andrew J E Seely, Irene Watpool, Rebecca Porteous, Michaël Chassé, Martine Lebrasseur, François Lauzier, Alexis F Turgeon, David Bellemare, Sangeeta Mehta, Emmanuel Charbonney, Émilie Belley-Côté, Édouard Botton, Dian Cohen, François Lamontagne, Neill K J Adhikari, OVATION-65 team members; Canadian Critical Care Trials Group. (2020). Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial. BMJ Open 10 (11), 1. (Published).
  • Chesnel, F., Couturier, A., Alusse, A., Gagné, J.-P., Poirier, G.G., Jean, D., Boisvert, F.-M., Hascoet, P., Paillard, L., Arlot-Bonnemains, Y. and Le Goff, X. (2020). The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation. PLoS Genetics 16 (11), 1. (Published).
  • *Dubois, M.-L., *Meller, A., Samandi, S., Brunelle, M., *Frion, J., Brunet, M., *Toupin, A., Beaudoin, M.C., Jacques, J,-F., *Lévesque, D., Scott, M.S., Lavigne, P., Roucou, X. and Boisvert, F.-M. (2020). UBB Pseudogene 4 encodes novel ubiquitin variants. Nature Communications 11 (1), 1306. (Published).
  • Del Olmo T, Lauzier A, Normandin C, Larcher R, Lecours M, Jean D, Lessard L, Steinberg F, Boisvert FM, Jean S. (2019). APEX2-mediated RAB proximity labeling identifies a role for RAB21 in clathrin-independent cargo sorting. Embo Reports e47192. doi: 10.1525 1. (Published).
  • Gonneaud A, Turgeon N, Jones C, Couture C, Lévesque D, Boisvert FM, Boudreau F, Asselin C. (2019). HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids. Scientific Reports 9 (1), 1. (Published).
  • Gordon, M.H., *Chauvin, A., Boisvert, F.-M. and MacNaughton W.K. (2019). Proteolytic processing of the epithelial adherens junction molecule E-cadherin by neutrophil elastase generates short peptides with novel wound healing bioactivity. Cellular and Molecular Gastroenterology and Hepatology. 7 (2), 483-486. (Published).
  • *Wilson, S, Babeu, JP, *Drissi, R, Lévesque, D., Boisvert, F.-M.# and Boudreau, F.# #Co-Senior authors. (2019). Quantitative Proteomics Identify a Novel DNA-Repair Dependent Protein Interactome of Hepatocyte Nuclear Factor 4alpha (HNF4a). Cancers (Basel) 11 (5), 1. (Published).
  • Del Olmo T, Lacarrière-Keïta C, Normandin C, Jean D, Boisvert FM, Jean S. (2019). RAB21 interacts with TMED10 and modulates its localization and abundance. Biology Open 8 (9), 1. (Published).
  • *Chauvin A, Boisvert FM. (2018). Clinical Proteomics in Colorectal Cancer, a Promising Tool for Improving Personalised Medicine. Proteomes 6 (4), 1. (Published).
  • *Drissi, R., *Chauvin, A., *McKenna, A., Lévesque, D., *Blais-Brochu, S., Jean, D. and Boisvert, F.-M. (2018). Destabilization of the MiniChromosome Maintenance (MCM) complex modulates the cellular response to DNA double strand breaks. Cell Cycle 17 (23), 2593-5609. (Published).
  • Brunet, M.A., Brunelle, M., Lucier, J.-F., Delcourt, V., Levesque, M., Grenier, F., Samandi, S., Leblanc, S., Aguilar, J.D., Dufour, P., Jacques, J.-F., Fournier, I., Ouangraoua, A., Scott, M.S., Boisvert, F.-M., Roucou X. (2018). OpenProt: a more comprehensive guide to exploreeukaryotic coding potential and proteomes. Nucleic Acids Research 10.1093/nar/gky936 1. (Published).
  • *Telekawa, C., #Boisvert, F.-M. and #Bachand, F. #: Co-senior authors. (2018). Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Nucleic Acids Research 46 (21), 1. (Published).
  • *Chauvin, A., *Mathieu, A.-A., Wang, C.S., Geha, S., Garde-Granger, P., and Boisvert, F.-M. (2018). The response to neoadjuvant chemoradiotherapy with 5-fluorouracil in locally advanced rectal cancer patients: a predictive proteomic signature. Clinical Proteomics 15 (16), 1. (Published).
  • Blain, J., Bédard, J., *Thompson, M., Boisvert, F.-M. and Boucher, M.-J. (2017). C-terminal deletion of NOTCH1 intracellular domain (N1ICD)increases its stability but does not amplify and recapitulate N1ICD-dependent signaling. Scientific Reports 7 (1), 5034. (Published).
  • Alexis Gonneaud, Claude Asselin, Francois Boudreau and Francois-Michel Boisvert. (2017). Phenotypic Analysis of Organoids by Proteomics. Proteomics 7 (1), 5034. (Published).
  • *Asselin-Mullen, P., *Chauvin, A., *Dubois, M.-L., *Drissi, R., Lévesque, D. and Boisvert, F.-M. (2017). Protein interaction network of alternatively spliced NudCD1 isoforms. Scientific Reports 7 (1), 12987. (Published).
  • *Chauvin, A. and Boisvert, F.-M. (2017). Proteomics analysis of colorectal cancer cell. Methods in Molecular Biology 1 1. (Published).
  • Gonneaud, A., Jones, C., Turgeon, N., Lévesque, D., Asselin, C., Boudreau, F. and Boisvert, F.-M. (2016). A SILAC-based method for quantitative proteomic analysis of intestinal organoids. Scientific Reports 6 38195. (Published).
  • *Dubois, M.-L., *Drissi, R., Lévesque, D. and Boisvert F.-M. (2016). Comprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry. Journal of Proteome Research 15 (9), 2924-34. (Published).
  • Landry-Voyer AM, Bilodeau S, Bergeron D, Dionne KL, Port SA, Rouleau C, Boisvert FM, Kehlenbach RH, Bachand F. (2016). Human PDCD2L is an export substrate of CRM1 that associates with 40S ribosomal subunit precursors. Molecular and Cellular Biology Oct 3 (MCB.00303), 1-10. (Published).
  • *Mathieu AA, *Ohl-Séguy E, *Dubois ML, Jean D, Jones C, Boudreau F, Boisvert FM. (2016). Subcellular proteomics analysis of different stages of colorectal cancer cell lines. Proteomics doi: 10.1002/pmic (201600314.), 1-10. (Published).
  • Thandapani, P., Gandin, V., Rouleau, S.G., Garant, J.-M., Boisvert, F.-M., Perreault, J.-P., Topisirovic, I., Richard, S. (2015). Aven recognition of RNA G-quadruplexes regulates the translation of Mixed Lineage Leukemia proteins. eLife 12 (4), 06234. (Published).
  • Benoit Marchand, Dominique Arsenault, Alexandre Raymond-Fleury, Francois-Michel Boisvert and MARIE-JOSÉE BOUCHER. (2015). Glycogen Synthase Kinase-3 (GSK3) inhibition induces pro-survival autophagic signals in human pancreatic cancer cells. Journal of Biological Chemistry 290 (9), 5592-605. (Published).
  • Alexis Gonneaud,Naomie Turgeon, François-Michel Boisvert, Claude Asselin. (2015). Loss of histone deacetylase Hdac1 disrupts metabolic processes in intestinal epithelial cells. FEBS Letters 14 (589), 2776-83. (Published).
  • *Drissi, R., *Dubois, M.-L., Douziech, M. and Boisvert, F.-M. (2015). Quantitative proteomics reveals dynamic interactions of the MCM complex in the cellular response to etoposide induced DNA damage. Molecular and Cellular Proteomics 14 (7), 2002-13. (Published).
  • Vanderperre B , Lucier JF , Bissonnette C , Motard J , Tremblay G , Vanderperre S , Wisztorski M , Salzet M , Boisvert FM , Roucou X. (2013). Direct detection of alternative open reading frames translation products in human significantly expands the proteome. PloS one 8 (8), 1-12. (Published).
  • *Drissi R , *Dubois ML , Boisvert FM. (2013). Proteomics methods for subcellular proteome analysis. The FEBS journal 280 (22), 5626-5634. (Published).
  • Boisvert FM , Ahmad Y , Gierli?ski M , Charrière F , Lamont D , Scott M , Barton G , Lamond AI. (2012). A quantitative spatial proteomics analysis of proteome turnover in human cells. Molecular & cellular proteomics : MCP 11 (3), 1-15. (Published).
  • Ahmad Y* , Boisvert FM* , Lundberg E , Uhlen M , Lamond AI * Co-First Authors. (2012). Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization. Molecular & cellular proteomics : MCP 11 (3), 1-15. (Published).
  • Dixon MJ , Gray A , Boisvert FM , Agacan M , Morrice NA , Gourlay R , Leslie NR , Downes CP , Batty IH. (2011). A screen for novel phosphoinositide 3-kinase effector proteins. Molecular & cellular proteomics : MCP 10 (4), 1-14. (Published).
  • Kliszczak AE , Rainey MD , Harhen B , Boisvert FM , Santocanale C. (2011). DNA mediated chromatin pull-down for the study of chromatin replication. Scientific reports 1 1-7. (Published).
  • Scott MS , Boisvert FM , Lamond AI , Barton GJ. (2011). PNAC: a protein nucleolar association classifier. BMC genomics 12 1-25. (Published).
  • Moore HM , Bai B , Boisvert FM , Latonen L , Rantanen V , Simpson JC , Pepperkok R , Lamond AI , Laiho M. (2011). Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation. Molecular & cellular proteomics : MCP 10 (10), 1-15. (Published).
  • Boisvert FM , Lam YW , Lamont D , Lamond AI. (2010). A quantitative proteomics analysis of subcellular proteome localization and changes induced by DNA damage. Molecular & cellular proteomics : MCP 9 (3), 457-470. (Published).
  • Scott MS , Boisvert FM , McDowall MD , Lamond AI , Barton GJ. (2010). Characterization and prediction of protein nucleolar localization sequences. Nucleic acids research 38 (21), 7388-7399. (Published).
  • Chamousset D , Mamane S , Boisvert FM , Trinkle-Mulcahy L. (2010). Efficient extraction of nucleolar proteins for interactome analyses. Proteomics 10 (16), 3045-3050. (Published).
  • Chamousset D , De Wever V , Moorhead GB , Chen Y , Boisvert FM , Lamond AI , Trinkle-Mulcahy L. (2010). RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits. Molecular biology of the cell 21 (23), 4212-26. (Published).
  • Boulon S , Westman BJ , Hutten S , Boisvert FM , Lamond AI. (2010). The nucleolus under stress. Molecular cell 40 (2), 216-227. (Published).
  • Boisvert FM , Lamond AI. (2010). p53-Dependent subcellular proteome localization following DNA damage. Proteomics 10 (22), 4087-4097. (Published).
  • Ahmad Y , Boisvert FM , Gregor P , Cobley A , Lamond AI. (2009). NOPdb: Nucleolar Proteome Database--2008 update. Nucleic acids research 37 181-184.
  • Trinkle-Mulcahy L , Boulon S , Lam YW , Urcia R , Boisvert FM , Vandermoere F , Morrice NA , Swift S , Rothbauer U , Leonhardt H , Lamond A. (2008). Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes. The Journal of cell biology 183 (2), 223-239.
  • Boisvert FM , van Koningsbruggen S , Navascués J , Lamond AI. (2007). The multifunctional nucleolus. Nature reviews. Molecular cell biology 8 (7), 574-585.
  • Gonsalvez GB , Tian L , Ospina JK , Boisvert FM , Lamond AI , Matera AG. (2007). Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. The Journal of cell biology 178 (5), 733-740.
  • Boisvert FM , Déry U , Masson JY , Richard S. (2005). Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes & development 19 (6), 671-676.
  • Boisvert FM , Hendzel MJ , Masson JY , Richard S. (2005). Methylation of MRE11 regulates its nuclear compartmentalization. Cell cycle (Georgetown, Tex.) 4 (7), 981-989.
  • Boisvert FM , Chénard CA , Richard S. (2005). Protein interfaces in signaling regulated by arginine methylation. Science's STKE : signal transduction knowledge environment 2005 (271), 1-11.
  • Boisvert FM , Rhie A , Richard S , Doherty AJ. (2005). The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. Cell cycle (Georgetown, Tex.) 4 (12), 1834-1841.
  • Boisvert FM , Déry U , Masson JY , Richard S. (2005). [A new role for arginine methylation in DNA repair]. Médecine sciences : M/S 21 (6-7), 579-581. (Published).
  • Boisvert FM , Richard S. (2004). Arginine methylation regulates the cytokine response. Molecular cell 15 (4), 492-494.
  • Boisvert FM , Côté J , Boulanger MC , Richard S. (2003). A proteomic analysis of arginine-methylated protein complexes. Molecular & cellular proteomics : MCP 2 (12), 1319-1330.
  • Côté J , Boisvert FM , Boulanger MC , Bedford MT , Richard S. (2003). Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Molecular biology of the cell 14 (1), 274-287.
  • Vieyra D , Loewith R , Scott M , Bonnefin P , Boisvert FM , Cheema P , Pastyryeva S , Meijer M , Johnston RN , Bazett-Jones DP , McMahon S , Cole MD , Young D , Riabowol K. (2002). Human ING1 proteins differentially regulate histone acetylation. The Journal of biological chemistry 277 (33), 29832-9. (Published).
  • Boisvert FM , Cote J , Boulanger MC , Cleroux P , Bachand F , Autexier C , Richard S. (2002). Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. The Journal of cell biology 159 (6), 957-969.
  • Bachand F , Boisvert FM , Côté J , Richard S , Autexier C. (2002). The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Molecular biology of the cell 13 (9), 3192-3202.
  • Côté F , Boisvert FM , Grondin B , Bazinet M , Goodyer CG , Bazett-Jones DP , Aubry M. (2001). Alternative promoter usage and splicing of ZNF74 multifinger gene produce protein isoforms with a different repressor activity and nuclear partitioning. DNA and cell biology 20 (3), 159-173.
  • Hendzel MJ , Kruhlak MJ , MacLean NA , Boisvert F , Lever MA , Bazett-Jones DP. (2001). Compartmentalization of regulatory proteins in the cell nucleus. The Journal of steroid biochemistry and molecular biology 76 (1-5), 9-21. (Published).
  • Wheaton K , Sampsel K , Boisvert FM , Davy A , Robbins S , Riabowol K. (2001). Loss of functional caveolae during senescence of human fibroblasts. Journal of cellular physiology 187 (2), 226-235.
  • Boisvert FM , Kruhlak MJ , Box AK , Hendzel MJ , Bazett-Jones DP. (2001). The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body. The Journal of cell biology 152 (5), 1099-1106.
  • Scott M , Bonnefin P , Vieyra D , Boisvert FM , Young D , Bazett-Jones DP , Riabowol K. (2001). UV-induced binding of ING1 to PCNA regulates the induction of apoptosis. Journal of cell science 114 (Pt 19), 3455-3462.
  • Scott M , Boisvert FM , Vieyra D , Johnston RN , Bazett-Jones DP , Riabowol K. (2001). UV induces nucleolar translocation of ING1 through two distinct nucleolar targeting sequences. Nucleic acids research 29 (10), 2052-2058.
  • Boisvert FM , Hendzel MJ , Bazett-Jones DP. (2000). Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA. The Journal of cell biology 148 (2), 283-292.
  • Chen T , Boisvert FM , Bazett-Jones DP , Richard S. (1999). A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines. Molecular biology of the cell 10 (9), 3015-3033.
  • Hendzel MJ , Boisvert F , Bazett-Jones DP. (1999). Direct visualization of a protein nuclear architecture. Molecular biology of the cell 10 (6), 2051-2062.

Chapitres de livre

  • *Chauvin, A. and Boisvert, F.-M. (2017). Proteomics analysis of colorectal cancer cell. Jean-Francois Beaulieu. Colorectal Cancer: Methods and Protocols. Methods in Molecular Biology (155-167). United States of America : Springer Editions. (Published).
  • Dubois, M.-L. and Boisvert, F.-M. (2016). The Dynamic Functions of the Nucleolus. David P. Bazett-Jones. The Nucleus. (Springer Editions, 1-20). United States of America : Springer Publishing. (Published).
  • Boisvert, F.-M. (2013). Chapter 1072: Nucleolus. Stanley Maloy,Kelly Hughes. Brenner's Encyclopedia of Genetics (2nd Edition, 1-22). United States of America : Elsevier Editions. (Published).
  • Hutton, s., Westman, B.J., Boisvert, F.-M., van Koningsbruggen, S. and Lamond, A.I. (2012). Chapter 12: The Nucleolus. Karsten Rippe. Genome Organization and Function in the Mammalian Cell Nucleus (279-295). Germany : Wiley-VCH. (Published).
  • Boisvert, F.-M., Ahmad, Y. and Lamond, A.I. (2011). Chapter 20: The Dynamic Proteome of the Nucleolus. Mark Olson. The Nucleolus. (347-366). United States of America : Springer Editions. (Published).

Ressources en ligne

  • Boisvert, F.-M., Ahmad, Y., and Lamond, A.I. (2012). Protein Turnover Viewer. Site Web.
  • Scott, M., Boisvert, F.-M., Lamond, A.I. and Barton, G.J. (2011). Nucleolar Localization Sequence Detector. Site Web.
  • Larance, M., Ten O Have, S., Ahmad, Y., Boisvert, F.-M., and Lamond, A.I. (2011). The Cell Biologist's Guide to Proteomics. Site Web.

Articles de conférence

  • *Marbach, G., *Frion, J., *Meller, A., Lévesque, D., Boisvert, F.-M. (2023). Caractérisation mécanistique et fonctionnelle d'un nouveau variant de l'ubiquitine: UbKEKS. 50ème journée de la Faculté de Médecine et des Sciences de la Santé. (Published).
  • *Lussier-Rousseau, K., Raisch, J., Lévesque, D., Bisaillon, M., Jeldres, C., Boisvert, F.-M. (2023). Development of a parallelreaction monitoring (PRM)-based quantitative proteomic approach for thedetection of bladder cancer in urine sample. Symposium de la recherche sur le cancer. (Published).
  • *Lussier-Rousseau, K., Raisch, J., Lévesque, D., Bisaillon, M., Jeldres, C., Boisvert, F.-M. (2023). Development of a parallelreaction monitoring (PRM)-based quantitative proteomic approach for thedetection of bladder cancer in urine sample. Canadian National Proteomic Network Symposium (Trainee symposium). (Published).
  • *Lussier-Rousseau, K., Raisch, J., Lévesque, D., Bisaillon, M., Jeldres, C., Boisvert, F.-M. (2023). Development of a parallelreaction monitoring (PRM)-based quantitative proteomic approach for thedetection of bladder cancer in urine sample. Canadian National Proteomic Network Symposium. (Published).
  • *Frion J., Roucou X., Boisvert F.M. (2022). 8e rencontres scientifiques universitaires Montpellier-Sherbrooke. 8e rencontres scientifiques universitaires Montpellier-Sherbrooke. (Published).
  • *Meller A., Bolten M., *Frion J., El Oualid F., Levesque D., Mayor T., Roucou X. Boisvert FM. (2022). Characterization of UbKEKS in the ubiquitylation cascade system. Canadian National Proteomics Network. (Published).
  • *Jurkovic, C-M., Raisch, J., Dong Nguyen, H., Tran,S., Lévesque, D., Scott, M., Campos, E., Boisvert, F-M. (2022). DNA replication fork’s proteome dynamics in presence of replicative stress. Oral presentation, Lightning talk & Poster presentation - Canadian National Proteomics Network CNPN's 13th Annual Symposium. (Published).
  • *Frion J., Roucou X., Boisvert F.M. (2022). Exploring the world of pseudogenes: a new ubiquitin variant to modulates genomic integrity. Rencontres Sherbrooke - Centre de Recherche en Cancérologie de Lyon (CRCL). (Published).
  • *Raisch, J., Groleau M., *Dubois ML., Lévesque D., Jacques PE., Boisvert FM. (2022). Identification of Cullin-RING E3 ubiquitin ligase complex (CRL) targets: characterization of DDB1 and CUL4-associated factors (DCAFs) substrates. Rencontres Sherbrooke - Centre de Recherche en Cancérologie de Lyon (CRCL). (Published).
  • A. Marcotte-Chénard, L. Deslauriers, A. Poupart, R. Tremblay, J. Little, F-M. Boisvert, M. Gayda, P. Geraldes, W. Mampuya and E. Riesco. (2022). Impact of High-Intensity Interval Training on Glycemic Variability in Older Women with Type 2 Diabetes : Does Volume Matter?. Diabetes Canada Conference. (Published).
  • A. Marcotte-Chénard, R. Tremblay, L. Deslauriers, A. Poupart, J. Little, F-M. Boisvert, M. Gayda, P. Geraldes, W. Mampuya and E. Riesco. (2022). Pression artérielle ambulatoire sur 24h :effet de l’entrainement par intervalles de haute intensité chez les femmesayant un diabète de type 2. 10e journée scientifique du DOCC (Diabète, Obésité et Complication Cardiovasculaire). (Published).
  • *Jurkovic, C-M., Raisch, J., Dong Nguyen, H., Tran,S., Lévesque, D., Scott, M., Campos, E., Boisvert, F-M. (2022). Proteome dynamics at DNA replication forks in presence of replicative stress. Poster presentation – Journée Scientifique de la FMSS. (Published).
  • *Jurkovic, C-M., *Raisch, J., Dong Nguyen, H., Tran,S., Lévesque, D., Scott, M., Campos, E., Boisvert, F-M. (2022). Proteome dynamics at DNA replication forks inpresence of replicative stress. Poster presentation – Retraite de l’Axe Cancer (Public Prize $150). (Published).
  • *Meller A., Levesque D., Roucou X. and Boisvert FM. (2022). RPS27AP5, a functional pseudogene. Rencontres Sherbrooke - Centre de Recherche en Cancérologie de Lyon (CRCL). (Published).
  • *Jurkovic, C-M., Raisch, J., Dong Nguyen, H., Tran,S., Lévesque, D., Scott, M., Campos, E., Boisvert, F-M. (2022). Space VS DNA: A high-resolution analysis ofprotein complexes recruited to the replication fork. Two oral presentation - 44th Committee on Space Research (COSPAR 2022). (Published).
  • *Frion J., Levesque D., Roucou X., Boisvert F.M. (2022). Using Data Independent Acquisition (DIA) to gaina dual-scale overview of the cellular function of the UbKEKS variant. 13th Annual Meeting of the CNPN. (Published).
  • *Jurkovic, C-M., *Raisch, J., Tran,S., Lévesque, D., Campos, E., Boisvert, F-M. (2021). Characterization by mass spectrometry of proteins interaction along the replication fork under stress condition. Canadian National Proteomics Network, CNPN 2021. (Published).
  • *Meller A., Roucou X. and Boisvert FM. (2021). Identification of a functional ribosomal pseudogene (RPS27AP5). Protein synthesis and Translation Control, EMBL. (Published).
  • *Raisch, J., Groleau M., *Dubois ML., Lévesque D., Jacques PE., Boisvert FM. (2021). Identification of protein substrates of the DDB1 and CUL4-associated factors (DCAFs). Canadian National Proteomics Network. (Published).
  • Alfonso AB., Pomerleau V., Reyes Nicolas V., Lévesque D., *Raisch, J. Boisvert, F.-M. and Perreault N. (2021). Matrisomic analysis of pre-neoplastic gastric subepithelial microenvironment from signaling-impaired telocytes mouse model. Canadian Digestive Diseases Week (CDDW). (Published).
  • *Frion J., *Dubois M.L., *Meller A., Lévesque D., Brunelle M., Roucou X., Boisvert F.M. (2021). Premiers aperçus sur le rôle du variant UbKEKS dans la régulation de PCNA, principal coordinateur pour la réplication et la réparation de l’ADN. 88e congrès international de l’ACFAS. (Published).
  • *Meller A., Roucou X. and Boisvert FM. (2021). Ribosomal protein S27Apseudogene 5 encodes functional ubiquitin and ribosomal proteins. Canadian National Proteomics Network. (Published).
  • *Frion J., *Meller A., *Dubois M.L., Roucou X., Boisvert F.M. (2021). UbKEKS : un nouveau variant d’ubiquitine vient élargir le groupe des régulateurs de PCNA, principal coordinateur des fourches de réplication. 12e édition de la Journée Phare, Congrès québécois en sciences de la santé. (Published).
  • *Jurkovic, C.-M., Lévesque, D., and Boisvert, F.-M. (2020). Changes in the replication fork proteome following DNA damages induced by Hydroxyurea. Genomic Stability and DNA Repair - Virtual Keystone Symposia. (Published).
  • *Frion, J., *Meller, A., *Dubois, M.-L., Lévesque, D., Brunelle, M., Roucou, X. and Boisvert, F.-M. (2020). Ubiquitin’s variant called UbKEKS has the potential to act as a new molecular switch for DNA repair mechanisms mediated by PCNA. Genomic Stability and DNA Repair - Virtual Keystone Symposia. (Published).
  • *Dubois, M.-L., Delattre, P., Brunelle, M., Jacques, J.-F.,* Lévesque, D., Delcourt, V., Beaudoin, M., Samandi, S., Brunet, M.A., Lavigne, P., Roucou, X. and Boisvert, F.-M. (2019). A novel ubiquitin variant regulating lamins A/B subcellular localization. The 11th Canadian National Proteomics Network Annual Meeting (CNPN). (Published).
  • *Chauvin, A., Wang, C.-S, Geha, S., Garde-Granger, P., Boisvert, F.-M. (2019). A proteomic analysis of chemoresistance development reveals novel biomarkers in rectal cancer. The 11th Canadian National Proteomics Network Annual Meeting (CNPN). (Published).
  • *Chauvin, A., Boisvert, F.-M. (2019). A proteomic analysis of chemoresistance development reveals novel biomarkers in rectal cancer. CNPN - Trainee symposium. (Published).
  • *McKenna, A., *Dubois, M.-L., Lévesques, D., Boisvert F.-M. (2019). Implication des protéines DCAFs dans la régulation du complexe ubiquitine ligase DDB1/CUL4 au nucléole. Journée scientifique de la FMSS. (Published).
  • *Lavergne, L., Lévesque, D., *Lambert, E., Boudreau, F., Boisvert F-M. (2019). La régulation de la stabilité des isoformes 2, 3, 7 et 9 du facteur nucléaire d’hépatocytes 4α par UBR5. Colloque de biologie cellulaire. (Published).
  • *McKenna, A., *Dubois, M.-L., Lévesques, D., Boisvert F.-M. (2019). Le rôle et le mécanisme de l'ubiquitine ligase DDB1/CUL4 dans la régulation des fonctions nucléolaires. Symposium de la recherche sur le cancer. (Published).
  • *Chauvin, A., Wang, C.-S, Geha, S., Garde-Granger, P., Boisvert, F.-M. (2019). Proteomic study of radio-chemoresistance in patients with locally advanced rectal cancer. 3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference. (Published).
  • *Tapp, G., Lévesque, D. and Boisvert, F.-M. (2019). Split BioID : Développement de la complémentation de fragments de biotine ligases afin d’augmenter la résolution dans la détection d'interactions protéines-protéines. Symposium de la recherche sur le cancer – CRCHUS. (Published).
  • *McKenna, A., *Dubois, M.-L., Lévesques, D., Boisvert F.-M. (2019). The role and mechanism of the DDB1/CUL4 ubiquitin ligase in regulating nucleolar functions. Canadian National Proteomics Network. (Published).
  • *Dubois, M.-L., Delattre, P., Brunelle, M., Jacques, J.-F., Lévesque, D., Delcourt, V., Beaudoin, M., Samandi, S., Brunet, M.A., Lavigne, P., Roucou, X. and Boisvert, F.-M. (2019). UbKEKS: a novel ubiquitin variant involved in DNA repair. 3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference. (Published).
  • *Chauvin, A. and Boisvert, F.-M. (2018). De nouveaux biomarqueurs pour prédire la résistance à laradio-chimiothérapie néoadjuvante au 5-fluorouracile dans le cancer rectal. 60ème réunion annuelle du CRCQ. (Accepted).
  • Gordon, M.H., *Chauvin, A., Boisvert, F.-M. and MacNaughton, W. (2018). Inflammatory proteases drive a migratory intestinal epithelial phenotype through the generation of bioactive peptide fragments of E-Cadherin. Canadian Digestive Week (CDDW). (Accepted).
  • *Lambert, É., Babeu, J.-P., *Jolibois, É., Lévesque, D., Boudreau, F. and Boisvert, F.-M. (2018). La panoplie d’isoformes du récepteur nucléaire HNF4? diffèrent au niveau de leurs fonctions transcriptionnelles et leurs réseaux d’interactions protéiques. Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé. (Accepted).
  • *Chauvin, A. and Boisvert, F.-M. (2018). La réponse à la radio-chimiothérapie dans le cancer rectal – Une signature protéique prédictive. 1er colloque de biologie cellulaire du Département d’Anatomie et de Biologie Cellulaire. (Accepted).
  • *Chauvin, A., Wang, C.-S., Geha, S., Garde-Granger, P. and Boisvert, F.-M. (2018). La résistance au traitement dans le cancer rectal : implication potentielle des voies de survie/nécroptose médiées par RIPK1. Signalisation Québec 2018. (Accepted).
  • *Chauvin, A., Wang, C.-S., Geha, S., Garde-Granger, P. and Boisvert, F.-M. (2018). La résistance au traitement dans le cancer rectal : implication potentielle des voies de survie/nécroptose médiées par RIPK1. 47ème Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé. (Accepted).
  • *Lambert, É., Babeu, J.-P., *Jolibois, É., Lévesque, D., Boudreau, F. and Boisvert, F.-M. (2018). Les 12 variants de HNF4? possèdent des fonctions transcriptionnelles et des réseaux d’interactions protéiques distincts. Signalisation Québec. (Accepted).
  • *Lambert, É., Babeu, J.-P., Lévesque, D., Boudreau, F. and Boisvert, F.-M. (2018). Role of the nuclear receptor HNF4? and its many isoforms in colorectal cancer. Canadian Digestive Diseases Week. (Accepted).
  • *Lambert, É., Babeu, J.-P., Lévesque, D., Boudreau, F. and Boisvert, F.-M. (2018). Role of the nuclear receptor HNF4? isoforms in colorectal cancer. Research topics - Canadian Association for Gastroenterology. (Accepted).
  • *Dubois, M.-L., Delattre, P., Beaudouin, M., Brunelle, M., Jacques, J.-F., Lévesque, D., Samandi, S., Lavigne, P., Roucou, X., Boisvert F.-M. (2018). UBKEKS: Découverte d’un nouveau variant d’ubiquitine qui ne cible pas les protéines au protéasome. 60ème réunion annuelle du CRCQ. (Accepted).
  • *Dubois, M.-L., Delattre, P., Delcourt. V., Beaudouin, M., Brunelle, M., Samandi, S., Lavigne, P., Roucou, X., Boisvert F.-M. (2018). UBKEKS: Découverte d’un nouveau variant d’ubiquitine qui ne cible pas les protéines au protéasome. Signalisation Québec. (Accepted).
  • *Dubois, M.-L., Delattre, P., Beaudouin, M., Brunelle, M., Jacques, J.-F., Lévesque, D., Samandi, S., Lavigne, P., Roucou, X., Boisvert F.-M. (2018). UbKEKS, a novel Ubiquitin isoform. OpenProt symposium. (Accepted).
  • *Dubois, M.-L., Delattre, P., Beaudouin, M., Brunelle, M., Jacques, J.-F., Lévesque, D., Samandi, S., Lavigne, P., Roucou, X., Boisvert F.-M. (2018). UbKEKS, une nouvelle isoforme de l’ubiquitine. Université d'Alger. (Accepted).
  • *Dubois, M.-L., Delattre, P., Beaudouin, M., Brunelle, M., Jacques, J.-F., Lévesque, D., Samandi, S., Lavigne, P., Roucou, X., Boisvert F.-M. (2018). UbKEKS: a novel ubiquitin variant expressed from a pseudogene. Human Proteome Organization World Congress. (Accepted).
  • *Lambert, E., Babeu, J.P., Lévesque, D., Boisvert, F.-M. and Boudreau, F. (2017). Caractérisation fonctionnelle de l’ensemble des isoformes de HNF4?. Journée scientifique de la FMSS. (Published).
  • *Lambert, E. Babeu, J.P., Boisvert, F.-M. and Boudreau, F. (2017). Caractérisation fonctionnelle des 12 isoformes du récepteur nucléaire HNF4?. CRCQ 2017. (Submitted).
  • *Chauvin A., Wang C.-S., Geha S., Garde-Granger P., Boisvert F.-M. (2017). Determination of a proteomic signature of the response to neoadjuvant radio-chemotherapy in colorectal cancer patients. Canadian Digestive Week (CDDW). (Published).
  • *Chauvin A., Wang C.-S., Geha S., Garde-Granger P., Boisvert F.-M. (2017). Détermination d’une signature protéomique prédictive de la réponse à la radio-chimiothérapie néoadjuvante au5-fluorouracil chez des patients atteints de cancer colorectal de stade III-IV. 46ème édition de la journée scientifique de la FMSS. (Published).
  • *Chauvin A., Wang C.-S., Geha S., Garde-Granger P., Boisvert F.-M. (2017). Identification de biomarqueurs protéiques prédictifs de la réponse à la radio-chimiothérapie néoadjuvante chez des patients atteints de cancer colorectal. 2ème édition du Symposium Proteomeus. (Published).
  • *Wilson, S., Babeu, J.-P,. Boisvert, F.-M., Boudreau F. (2017). L’interaction entre HNF4alpha et les protéines de réparation de l’ADN : un lien exploitable pour le traitement du cancer colorectal?. Club de recherches cliniques du Québec (CRCQ). (Submitted).
  • *Wilson, S., Babeu, J.-P., Boisvert, F.-M., Boudreau, F. (2017). Newly identified interacting proteins of HNF4? reveal a novel DNA repair role in colorectal cancer. Proteomeus 2017. (Published).
  • *Wilson, S., Babeu, J.-P., Boisvert, F.-M., Boudreau, F. (2017). The P2 isoform class of the transcription factor HNF4alpha plays DNA repair role in colorectal cancer. Research Topics in GI Disease Meeting. (Published).
  • *Wilson, S., Babeu, J.-P., Boisvert, F.-M., Boudreau, F. (2017). The P2 isoform class of the transcription factor HNF4alpha plays DNA repair role in colorectal cancer. Canadian Digestive Diseases Week 2017. (Published).
  • *Dubois, M.-L., Lévesques, D. and Boisvert, F.-M. (2016). A role for the MCM complex during the cellular response to DNA damage. Mammalian DNA Repair: Gordon Research Conference. (Published).
  • *Wilson, S., Babeu J.-P., Boisvert, F.-M., and Boudreau, F. (2016). HNF4alpha aurait un rôle potentiel dans les mécanismes de réparation de l’ADN lors du cancer colorectal. CRCQ 2016. (Published).
  • *McKenna, A., *Dubois,M.-L., Lévesque, D. and Boisvert, F.-M. (2016). Identification des cibles du complexe d'ubiquitine ligase DDB1-Cul4 l'aide des protéines adaptatrice DCAF. Signalisation Québec 2016. (Published).
  • *Lacasse, V., Lévesque, D., Wang, C-S., Garde-Granger, P., Geha, S., Boisvert, F-M. (2016). Identification des voies de signalisation dérégulées pour l’identification de biomarqueurs prédictifs de la réponse au traitement du cancer colorectal. Signalisation Québec 2016. (Published).
  • *Drissi, R., Jean, D., and Boisvert, F.-M. (2016). Le complexe MCM et la réponse aux cassures doubles brins de l'ADN. ACFAS. (Published).
  • *Dubois, M.-L. Lévesque, D., and Boisvert, F.-M. (2016). Une étude quantitative de spectrométrie de masse a révélé une dynamique d’interaction pour les protéines MCM en réponse aux dommages à l’ADN. Symposium Protéomeus. (Published).
  • *Dubois, M.-L. *Mckenna, A., *Lacasse, V., Lévesque, D., and Boisvert, F.-M. (2016). Étude du complexe d'ubiquitine ligase DDB1-Cullin4. 45e Journée scientifique de la FMSS. (Published).
  • *Dubois, M.-L., Lévesque, D. and Boisvert, F.-M. (2015). A role for the MCM complex during the cellular response to DNA damage. Mammalian DNA Repair : Gordon Research Conference. (Published).
  • *Asselin-Mullen, P., Lévesque, D. and Boisvert, F.-M. (2015). Caractérisation des fonctions moléculaires des isoformes de NudCD1. Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé – 44e édition. (Published).
  • *Asselin-Mullen, P., Lévesque, D. and Boisvert, F.-M. (2015). Characterization of the molecular functions of NudCD1 isoforms in colorectal cancer cell lines. 2015 CAG Canadian Digestive Diseases Week Winter Meeting. (Published).
  • St-Jean, S., Boisvert, F.-M. and Boudreau, F. (2015). Identification of CHD8 interacting with the transcriptional repressor NCoR. Canadian Journal of Gastroenterology and Hepatology. CDDW 2015. (Published).
  • *Drissi, R., Jean, D. and Boisvert, F.-M. (2015). Implication du complexe MCM dans la réponse aux cassures double brin de l'ADN. 44e Journée scientifique de la FMSS. (Published).
  • *Dubois, M.-L., Lévesque, D. and Boisvert, F.-M. (2015). Interactions et modifications post-traductionnelles des protéines MCM suite aux dommages àl’ADN. 44e Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé de l’université de Sherbrooke. (Published).
  • *Thompson, M., Douziech, M., Arsenault, D., Boucher, M.-J. and Boisvert, F.-M. (2015). Proteomic analysis of NOTCH1: Establishment of a reliable system to identify new NOTCH1 interacting partners. Canadian Digestive Disease Week 2015. (Published).
  • *Dubois, M.-L. and Boisvert, F.-M. (2015). Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Canadian Cancer Research Conference. (Accepted).
  • Babeu, J.-P., Carrier, J., Boisvert, F.-M. and Boudreau, F. (2015). Transcriptomic and proteomic analysis of HNF4alpha isoforms functions support opposite roles for these during colon cancer. Canadian Journal of Gastroenterology and Hepatology (CDDW 2015). (Published).
  • *Drissi, R., Jean, D. and Boisvert, F.-M. (2014). Implication des protéines MCM2 et MCM3 dans les mécanismes de réparation des cassures double brin de l'ADN. 43e Journée scientifique de la FMSS. (Published).
  • Babeu, J.-P., Boisvert, F.-M. and Boudreau, F. (2014). Optimization of a SILAC quantitative proteomic approach to identify specific interacting cofactors of HNF4alpha P1 and P2 isoforms. Canadian Journal of Gastroenterology and Hepatology (CDDW 2014). (Published).
  • *Mathieu, A.-A., *Drissi, R., *Ohl-Séguy, E. and Boisvert F.-M. (2014). Proteomic analysis of different stages of colorectal cancer cell lines and tissues. 2014 Research Topics in GI Disease. (Accepted).
  • *Asselin-Mullen, P., Lévesque, D. et Boisvert, F.-M. (2014). Rôle des différentes isoformes de NudCD1 dans le cancer colorectal. Journée Phare Rencontre interuniversitaire en pharmacologie – 6e édition. (Published).
  • *Asselin-Mullen, P., Lévesque, D. and Boisvert, F.-M. (2014). Rôle des différentes isoformes de NudCD1 dans le cancer colorectal. Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé – 43e édition. (Published).
  • *Asselin-Mullen, P., Lévesque, D. and Boisvert, F.-M. (2014). Rôle des différentes isoformes de NudCD1 dans le cancer colorectal. Symposium de la recherche sur le cancer. (Published).
  • *Dubois, M.-L., Lévesques, D. and Boisvert, F.-M. (2014). Étude des domaines d’interactions de la protéine MCM2 avec ASF1 par fragmentome quantitatif. 43e Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé de l’université de Sherbrooke. (Published).
  • *Dubois, M.-L., Lévesques, D. and Boisvert, F.-M. (2014). Étude des domaines d’interactions de la protéine MCM2 par fragmentome quantitatif. Journée phare 6e édition. (Published).
  • *Dubois, M.-L., Lévesques, D. and Boisvert, F.-M. (2014). Étude des domaines d’interactions de la protéine MCM2 par fragmentome quantitatif. Signalisation Québec. (Published).
  • *Asselin-Mullen, P. and Boisvert, F.-M. (2013). Analyse des partenaires d’interaction de MCM2 par spectrométrie de masse. 9ième Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé, Sherbrooke. (Published).
  • *Thompson, M., Douziech, M.,Boisvert, F.-M. and Boucher, M.-J. (2013). Analyse protéomique des partenaires d’interaction de Notch1: identification du complexe médiateur. Journée Phare, Magog-Orford, Québec, Canada. (Accepted).
  • *Thompson, M., Douziech, M., Boisvert, F.-M. and Boucher, M.-J. (2013). Analyse protéomique des partenaires d’interaction de Notch1: identification du complexe médiateur. Club de Recherches Cliniques du Québec, Lac Delage, Québec, Canada. (Published).
  • *Thompson, M., Douziech, M., Boisvert, F.-M. and Boucher,M.-J. (2013). Analyse protéomique des partenaires d’interaction de Notch1: identification du complexe médiateur. 9e Journée Scientifique du 1er cycle. (Published).
  • *Uribe Marioni, L. L. and Boisvert, F.-M. (2013). Characterization of the MCM complex in response to DNA damage. University of Chihuahua. (Published).
  • *Thompson, M., Douziech, M., Boisvert, F.-M. and Boucher,M.-J. (2013). Identification de nouveaux partenaires d’interaction du fragment actif de Notch1 par spectrométrie de masse. Symposium d’ouverture des Conférences Interdisciplinaires sur le Cancer (CIC). (Published).
  • *Drissi, R. and Boisvert, F.-M. (2013). Proteomic analysis of different stages of colorectal cancer cell lines. Canadian Digestive Disease Week 2013. (Published).
  • *Asselin-Mullen, P. and Boisvert, F.-M. (2013). Proteomic analysis of protein interactions of the MCM complex through the cell cycle. 10th Symposium on the Physiology and Diseases of the Digestive Tract. (Published).
  • *Dubois, M.-L., *Drissi,R., Douziech, M., Boisvert, F.-M. (2013). Role and interaction of proteins MCM during DNA repair. Research Topics in GI Disease XII. (Published).
  • *Dubois, M.-L., Douziech, M. and Boisvert, F.-M. (2013). Role and interaction of proteins MCM during DNA repair. Canadian Digestive Disease Week 2013. (Published).
  • *Dubois, M.-L., Douziech, M. and Boisvert, F.-M. (2012). Interaction des proteins du complexe MCM dans les mécanismes de reparation de l’ADN. Journée Scientifique de la Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke. (Published).
  • *Dubois, M.-L., Douziech, M. and Boisvert, F.-M. (2012). Interaction of MCM proteins during DNA repair. 4th Annual Edtion of La Journée Phare. (Published).
  • Boisvert, F.-M. (2012). Proteomic analysis of different stages of colorectal cancer cell lines. CIHR New Principal Investigator Meeting – Institute of Nutrition, Metabolism and Diabetes. (Published).

Autres contributions

Présentations

  • (2023). L’IRCUS : un nouvel institut universitaire voué à la lutte contre le cancer. Conferences. Grenobles, France
  • (2023). On the road to diagnostic and prognostic biomarkers discovery using proteomics. CDDW - CLM 2023. Halifax, Canada
  • (2023). Organoids proteomics using quantitative mass spectrometry approaches. Invited speaker - 3DOnco visit - CRCL. Lyon, France
  • (2023). Un nouveau variant de l'ubiquitine encodé par un pseudogène impliqué dans la réplication de l'ADN. Invited speaker - CRCHUQ, Université Laval. Québec, Canada
  • (2023). Using proteomics for biomarkers discovery. BioMérieux collaborative presentations. Lyon, France
  • (2023). À la découverte de biomarqueurs! Test urinaire diagnostic pour le cancer de la vessie. BistroBrain - Santé. Sherbrooke, Canada
  • (2022). Diagnostic and prognostic potential of proteomic profiling for the discovery of protein biomarkers in cancer. Montreal Mass Spectrometry Discussion Group (MMSDG). Montreal, Canada
  • (2022). Diagnostic and prognostic potential of proteomic profiling for the discovery of protein biomarkers in cancer. CRCHUM Conferences. Montreal, Canada
  • (2022). More ubiquitins than meets the eye: Novel variants encoded by ubiquitin pseudogenes. University of British Columbia Seminar. Canada
  • (2022). Régulation de la réplication de l’ADN par la modification de PCNA par UbKEKS. Signalisation Québec 2022. Canada
  • (2022). UbKEKS, A novel ubiquitin variant encoded by a pseudogene. CNPN symposium. Canadian National Proteomics Network. Canada
  • (2021). Un nouvel institut universitaire voué à la lutte contre le cancer. Mission diplomatique: Centre de Recherche en Cancérologie de Lyon (CRCL). France
  • (2019). More ubiquitins than meets the eye: Novel variants encoded by ubiquitin pseudogenes. McGill Seminars. Canada
  • (2018). Functions of Ubiquitin and Novel Ubiquitin Variants in DNA Replication and Repair. Charbonneau Special Seminar. Calgary, Canada
  • (2017). Cell Biology Through Proteomics in Space and Time. CFABS - 2017 Toronto Spring Mass Spectrometry Group Meeting. Canada
  • (2016). Spatial Proteomics – where cell biology meets mass spectrometry. Seminar - Sick Kids Hospital, University of Toronto. Toronto, Canada
  • (2016). The Proteomics of Colorectal Cancer: Identification of a Protein Signature Associated with Prognosis. Canadian Digestive Diseases Week 2016. Montreal, Canada
  • (2015). Comprehensive characterization of Minichromosome Maintenance Complex (MCM) protein interactions using affinity and proximity purifications coupled to mass spectrometry. Department of Gene Regulation and Expression Seminars. Dundee, United Kingdom
  • (2015). Le rôle du complexe MCM dans la réponse cellulaire aux dommages à l’ADN. CRCQ 2015. Sacacomie, Canada
  • (2014). Dynamics of protein interactions of the MCM complex in response to DNA damage. Sixth Annual Canadian National Proteomics Network Symposium. Montreal, Canada
  • (2014). Dynamique des interactions du complexe MCM en réponse aux dommages à l'ADN. Signalisation Québec. Bécancour, Canada
  • (2013). La redistribution subcellulaire des protéines en réponse aux dommages à l’ADN : un rôle pour le complexe MCM dans la réparation de l’ADN. L'Institut du Cancer de Montréal et le Centre de Recherche du CHUM seminars. Montreal, Canada
  • (2013). Omics/Proteomics of Colorectal Cancer. Canadian Digestive Disease Week 2013 (CDDW 2013). Victoria, Canada
  • (2013). Proteomic Analysis of Human Intestinal Epithelial Cells. 10th Symposium on the Physiology and Diseases of the Digestive Tract. Magog, Canada
  • (2013). Une approche protéomique pour étudier la redistribution subcellulaire des protéines en réponse aux dommages à l'ADN. Invited speaker, Centre de Recherche du CHUQ (CHUL). Québec, Canada
  • (2012). De Montréal à Sherbrooke, un voyage de 10,000 km à travers la science!. Journal Club, Department of Anatomy and Cell Biology, Université de Sherbrooke. Sherbrooke, Canada
  • (2012). Dynamics of protein interactions during the cellular response to DNA damage. 19th Methods in Protein Structure Analysis Conference. Ottawa, Canada
  • (2011). A Quantitative Spatial Proteomic Analysis of Proteome Turnover in Human Cancer Cells. Cancer Proteomics EMBO Meeting. Dublin, Ireland