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Philippe Dauphin Ducharme

Professeur, Faculté des sciences
FAC. SCIENCES Chimie

Présentation

Sujet de recherche

Systèmes électrochimiques, Nanosystèmes, Biotechnologie

Disciplines de recherche

Chimie

Mots-clés

Biosenseurs, ADN, Électrochimie, Biophysique, Corrosion, Chimie supramoléculaire, Synthèse Inorganique, Pharmacologie

Intérêts de recherche

Biosenseurs / ADN / Protéines / Électrochimie / Détection en temps réel / Pharmacocinétique / Chimie supramoléculaire / Corrosion / Chimie des matériaux / Synthèse inorganique

Langues parlées et écrites

Anglais, Français

Diplômes

(2019). (Postdoctorat, ). University of California, Santa Barbara.

(2015). SECM Study of Mg Alloys to Develop Anti-Corrosion Mechanism for Industrial Applications (Doctorat, Chemistry). McGill University.

(2011). (Baccalauréat, Chimie). Université de Montréal.

Expérience académique

Assistant Professor. (2020-). Université de Sherbrooke. Canada.

Post-doctoral Fellow. (2015-2019). University of California, Santa Barbara. États-Unis.

Ph.D. Candidate. (2011-2015). McGill University. Canada.

Teaching Assistant for the Organic Chemistry I laboratory. (2012-2012). McGill University. Canada.

JCEMolChem Intern. (2011-2011). Université de Paris VI (P & M Curie). France.

NSERC Summer Internship. (2010-2010). Université de Montréal. Canada.

NSERC Summer Internship. (2009-2009). Université du Québec à Montréal. Canada.

Summer Internship. (2007-2007). Université du Québec à Montréal. Canada.

Prix et distinctions

  • (2018) Postdoctoral Fellowship. Conseil de recherches en sciences naturelles et en génie (CRSNG). (Prix / Récompense).
  • (2017) Postdoctoral research scholarship (B3). Fonds de recherche du Québec - Nature et technologies (FRQNT). (Prix / Récompense).
  • (2015) Bourses de doctorat en recherche (B2). Fonds de recherche du Québec - Nature et technologies (FRQNT). (Prix / Récompense).
  • (2015) NSERC Postgraduate Scholarships-Doctoral Program. Conseil de recherches en sciences naturelles et en génie (CRSNG). (Prix / Récompense).
  • (2013) 2nd Best Poster. Electrochemical Society of Canada. (Prix / Récompense).
  • (2013) Bourses de mai?trise en recherche (B1). Fonds de recherche du Québec - Nature et technologies (FRQNT). (Prix / Récompense).
  • (2013) Edward G. Weston Award. Electrochemical Society. (Prix / Récompense).
  • (2013) Research Mobility Award. McGill University. (Prix / Récompense).
  • (2012) 2nd Best Poster. NACE. (Prix / Récompense).
  • (2011) Bourse Lucien Piché. Lucien Piché. (Prix / Récompense).
  • (2011) Bourse de Prestige. Université de Montréal. (Prix / Récompense).
  • (2011) Bourse JCEMolChem. JCEMolChem. (Prix / Récompense).
  • (2010) Best Undergraduate Poster. SACIQ. (Prix / Récompense).
  • 2nd Best Thesis in 180s. Centre Québecois sur les Matériaux Fonctionnels. (Prix / Récompense).
  • Best Oral Presentation. Canadian Society of Chemistry. (Prix / Récompense).
  • ISE Young Electrochemist Travel Award. International Society of Electrochemistry. (Prix / Récompense).
  • J. E. Griffiths Award. McGill University. (Prix / Récompense).
  • Pall Dissertation Award. McGill University. (Prix / Récompense).
  • Plaque des Industries Chimiques. Société des Industries Chimiques. (Prix / Récompense).

Financement

  • Subvention. (Obtenu). Demandeur principal. Start-up fund. Université de Sherbrooke. Start-up for new professors. 50 000 $. (2020-2023)
  • Subvention. (En cours d’évaluation). Demandeur principal. Platform for In Vivo and In Vitro Electrochemical Biosensor Characterization. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Research Tools and Instruments. 117 067 $. (2020-2021)
  • Bourse de recherche. (Terminé). Chercheur principal. PDF - NSERC. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). 90 000 $. (2016-2018)
  • Bourse de recherche. (Terminé). Chercheur principal. Postdoctoral research scholarship (B3). Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT). 70 000 $. (2015-2016)
  • Bourse d’études. (Décliné). Demandeur principal. Doctoral Research Scholarships (B2). Fonds de recherche du Québec - Nature et technologies (FRQNT). Bourses de doctorat en recherche (B2). 60 000 $. (2013-2015)
  • Bourse d’études. (Terminé). Demandeur principal. PGSD - NSERC. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Bourse d’études supérieures du CRSNG – doctorat. 63 000 $. (2013-2015)
  • Bourse d’études. (Terminé). Demandeur principal. Master's Research Scholarships (B1). Fonds de recherche du Québec - Nature et technologies (FRQNT). Bourses de maîtrise en recherche (B1). 30 000 $. (2011-2013)
  • Bourse d’études. (Terminé). Demandeur principal. CGSM - NSERC. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Bourse d’études supérieures du Canada au niveau de la maîtrise. 17 500 $. (2011-2012)
  • Bourse d’études. (Terminé). Demandeur principal. Undergraduate Student Research Awards - NSERC. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Bourse de recherche de 1er cycle. 4 500 $. (2010)
  • Bourse d’études. (Terminé). Demandeur principal. Undergraduate Student Research Awards - NSERC. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Bourse de recherche de 1er cycle. 4 500 $. (2009)

Publications

Articles de revue

  • Arroyo-Currás, N., Dauphin-Ducharme, P., Scida K., Chávez, J. L. (2020). From the beaker to the body: translational challenges for electrochemical, aptamer-based sensors. Analytical Methods 12 1288-1310. DOI. (Article publié).
  • Philippe Dauphin Ducharme, Kyungae Yang, Netzahualcoyotl Arroyo-Currás, Kyle L. Ploense, Yameng Zhang, Julian Gerson, Martin Kurnik, Tod E. Kippin, Milan N. Stojanovic, Kevin W. Plaxco. (2019). Electrochemical Aptamer-based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-controlled Drug Delivery. ACS Sensors 4 (10), 2832-2837. DOI. (Article publié).
  • Philippe Dauphin Ducharme, Netzahualcoyotl Arroyo-Currás, Kevin W. Plaxco. (2019). High-precision electrochemical measurements of the guanine-, mismatch- and length-dependence of electron transfer in surface-attached DNA are consistent with a collision-mediated mechanism. Journal of the American Chemical Society 141 1304-1311. DOI. (Article publié).
  • Gabriel Ortega, Martin Kurnik, Philippe Dauphin Ducharme, Hui Li, Netzahualcoyotl Arroyo-Currás, Amanda Caceres, Kevin W. Plaxco. (2019). Surface attachment enhances the thermodynamic stability of protein L. Angewandte Chemie – International Edition 58 1714-1718. DOI. (Article publié).
  • Netzahualcoyotl Arroyo-Currás, Philippe Dauphin Ducharme, Gabriel Ortega, Kyle L. Ploense, Tod E. Kippin, Kevin W. Plaxco. (2018). **COVER** Real-time, sub-second-resolved measurement ofspecific molecules directly in the living body using chronoamperometricallyinterrogated E-AB sensors **COVER**. ACS Sensors 3 360-366. DOI. (Article publié).
  • Philippe Dauphin Ducharme, Netzahualcoyotl Arroyo-Currás, Ramesh Adhikari, Jacob Somerson, Gabriel Ortega, Dmitrii E. Makarov, Kevin W. Plaxco. (2018). Chains Dynamics Limit Electron Transfer from Electrode-Bound, Single-Stranded Oligonucleotides. Journal of Physical Chemistry C 122 21441-21448. DOI. (Article publié).
  • Martin Kurnik, Gabriel Ortega, Philippe Dauphin Ducharme, Hui Li, Amanda Caceres, Kevin W. Plaxco. (2018). Quantitative measurements of protein-surfaceinteraction thermodynamics. Proceedings of the National Academy of Sciences of the United States of America 115 DOI. (Article publié).
  • Hui Li, Philippe Dauphin Ducharme, Gabriel Ortega, Kevin W. Plaxco. (2017). **ACS Select** Calibration-free electrochemical biosensors supporting accurate molecular measurements directly in undiluted whole blood **ACS Select**. Journal of the American Chemical Society 139 11207-11213. DOI. (Article publié).
  • Hui Li, Philippe Dauphin Ducharme, Netzahualcoyotl Arroyo-Currás, Claire Tran, Philip A. Vieira, Shaoguang Li, Christina Shin, Jacob Somerson, Tod E. Kippin, Kevin W. Plaxco. (2017). **VIP** A biomimetic surface greatly improves thein-vivo performance of electrochemical aptamer-based sensors. **VIP**. Angewandte Chemie – International Edition 88 7492-7495. DOI. (Article publié).
  • Philippe Dauphin Ducharme, Netzahualcoyotl Arroyo-Currás, Martin Kurnik, Gabriel Ortega, Hui Li, Kevin W. Plaxco. (2017). A Simulation-Based Approach to Determining Electron Transfer Rates using Square-Wave Voltammetry. Langmuir 33 4407-4413. DOI. (Article publié).
  • David Polcari, Philippe Dauphin Ducharme, Janine Mauzeroll. (2016). **COVER** Scanning Electrochemical Microscopy: A Comprehensive Review of Experimental Parameters from 1989-Present. **COVER**. Chemical Reviews 116 13043-14276. DOI. (Article publié).
  • Philippe Dauphin Ducharme, Kevin W. Plaxco. (2016). Maximizing the Signal Gain of Electrochemical-DNA Sensors. Analytical Chemistry 88 11654-11662. DOI. (Article publié).
  • Philippe Dauphin-Ducharme, Janine Mauzeroll. (2015). **COVER** Surface Analytical Methods Applied to Magnesium Corrosion **COVER**. Analytical Chemistry 87 7499-7509. DOI. (Article publié).
  • Philippe Dauphin-Ducharme, Christian Kuss, David Rossouw, Nicholas A. Payne, Laurence Danis, Gianluigi A. Botton, Janine Mauzeroll. (2015). Corrosion Product Formation Monitored Using the Feedback Mode of Scanning Electrochemical Microscopy with Carbon Microelectrodes. Journal of the Electrochemical Society 162 (12), C677-C683. DOI. (Article publié).
  • Philippe Dauphin-Ducharme, W. Jeffrey Binns, Michael E. Snowden, David W. Shoesmith, Janine Mauzeroll. (2015). Determination of the local corrosion rate of magnesium alloys using a shear force mounted scanning microcapillary method. Faraday Discussion 180 331-345. DOI. (Article publié).
  • Philippe Dauphin-Ducharme, Mohsen Danaie, R. Matthew Asmussen, David W. Shoesmith, Janine Mauzeroll. (2015). In-situ Mg2+ release monitored during magnesium alloy corrosion. Journal of Electroanalytical Chemistry 736 61-68. DOI. (Article publié).
  • Ushula Mengesha Tefashe, Philippe Dauphin-Ducharme, Mohsen Danaie, Zach P. Cano, Joey R. Kish, Gianluigi A. Botton, Janine Mauzeroll. (2015). Localized Corrosion Behavior of AZ31B Magnesium Alloy with an Electrodeposited Poly(3,4-Ethylenedioxythiophene) Coating. Journal of the Electrochemical Society 162 C536-C544. DOI. (Article publié).
  • R. Matthew Asmussen, W. Jeffrey Binns, Pellumb Jakupi, Philippe Dauphin-Ducharme, Ushula M. Tefashe, Janine Mauzeroll, David Shoesmith. (2015). Reducing the corrosion rate of magnesium alloys using ethylene glycol for advanced electrochemical imaging. Corrosion Science 93 70-79. DOI. (Article publié).
  • Amlan K. Pal, Philippe Dauphin-Ducharme, Garry S. Hanan. (2014). Enhanced stereoselectivity in a di-Ru(II) complex of an achiral bis-bidentate ligand. Chemical Communications 50 (25), 3303-3305. DOI. (Article publié).
  • Nicolas Cottenye, Gustavo Carbajal, Zhong-Kai Cui, Philippe Dauphin-Ducharme, Janine Mauzeroll, Michel Lafleur. (2014). Formation, stability, and pH sensitivity of free-floating, giant unilamellar vesicles using palmitic acid–cholesterol mixtures. Soft Matter 10 6451-6456. DOI. (Article publié).
  • Philippe Dauphin-Ducharme, R. Matthew Asmussen, Ushula M. Tefashe, Mohsen Danaie, W. Jeffrey Binns, Pellumb Jakupi, Gianluigi A. Botton, David W. Shoesmith and Janine Mauzeroll. (2014). Local Hydrogen Fluxes Correlated to Microstructural Features of a Corroding Sand Cast AM50 Magnesium Alloy. Journal of the Electrochemical Society 161 C557-C564. DOI. (Article publié).
  • Ushula Mengesha Tefashe, Michael Edward Snowden, Philippe Dauphin-Ducharme, Mohsen Danaie, Gianluigi A. Botton, Janine Mauzeroll. (2014). Local flux of hydrogen from magnesium alloy corrosion investigated by scanning electrochemical microscopy. Journal of Electroanalytical Chemistry 720-721 121-127. DOI. (Article publié).
  • Philippe Dauphin-Ducharme, Fiora Rosati, Andrea Greschner, A. Dowine De Bruijn, Danielle Salvatore, Violeta Toader, Kai Lin Lau, Janine Mauzeroll and Hanadi Sleiman. (2014). Modulation of Charge Transport Across Double-Stranded DNA by the Site-Specific Incorporation of Copper Bis-Phenanthroline Complexes. Langmuir 31 1850-1854. DOI. (Article publié).
  • Dao Trinh, Philippe Dauphin-Ducharme, Ushula Mengesha Tefashe, Joseph R. Kish, and Janine Mauzeroll. (2012). Influence of Edge Effects on Local Corrosion Rate of Magnesium Alloy/Mild Steel Galvanic Couple. Analytical Chemistry 84 899-906. DOI. (Article publié).
  • Samik Nag, Janaina G. Ferreira, Ludwig Chenneberg, Philippe Dauphin-Ducharme, Garry S. Hanan, Giuseppina La Ganga, Scolastica Serroni, Sebastiano Campagna. (2011). Changing the Role of 2,2?-Bipyridine from Secondary Ligand to Protagonist in [Ru(bpy)2(N?N)]2+ Complexes: Low-Energy, Red Emission from a Ruthenium(II)-to-2,2?-Bipyridine 3MLCT State. Inorganic Chemistry 50 7-9. DOI. (Article publié).

Articles de magazine

  • Philippe Dauphin-Ducharme. (2013). Assessment of magnesium alloy corrosion using potentiometric mode of scanning electrochemical microscopy. Electrochemical Society Interface. 22(4). 83-84.

Rapports

  • Dauphin-Ducharme, P., Binns, W. J., Shoesmith, D. W. and Mauzeroll, J. (2015). Determination of the Local Corrosion Rate of Magnesium Alloys using a Shear Force Mounted Scanning Microcapillary Method. General Motors. 19 p.
  • Tefashe, U. M., Dauphin-Ducharme, P., Danaie, M., Cano, Z. P., Kish, J. R., Botton, G. A., Mauzeroll, J. (2015). Localized Corrosion Behavior of AZ31B Mg Alloy with a PEDOT Coating. General Motors. 35 p.
  • Dauphin-Ducharme, P., Asmussen, R. M., Tefashe, U. M., Danaie, M., Binns, J., Jakupi, P., Botton, G. A., Shoesmith, D. W. and Mauzeroll, J. (2014). Microgalvanic Corrosion of Sand Cast AM50 Mg Alloy Assessed using the Substrate-Generation / Tip-Collection Mode of SECM. General Motors. 23 p.
  • Dauphin-Ducharme, P., Snowden, M. E., Mauzeroll, J. (2014). Shear Force Controlled Scanning Micropipet for High Resolution Topographic Imaging. General Motors. 13 p.
  • Tefashe, U. M., Dauphin-Ducharme, P., Mauzeroll, J. (2014). Study of the Local Electrodeposition of PEDOT on AZ31 Alloy in Ionic Liquid and Corrosion Behavior of the Coated Alloy. General Motors. 18 p.
  • Tefashe, U. M., Snowden, M. E., Dauphin-Ducharme, P., Danaie, M., Botton, G. A., Mauzeroll, J. (2013). (2013). Local Rate of Hydrogen Evolution from Magnesium Alloy Corrosion Investigated by SECM. General Motors. 20 p.
  • Dauphin-Ducharme, P., Tefashe, U. M., Trinh, D., Kish, J., Mauzeroll, J. (2012). Influence of Edge Effects on Local Corrosion Rate of Magnesium Alloy/Mild Steel Galvanic Couple. General Motors. 21 p.
  • Tefashe, U. M., Dauphin-Ducharme, P., Mauzeroll, J. (2012). Influence of Microstructure on Local Corrosion Properties of AM50 Magnesium Alloys Studied by Scanning Electrochemical Microscopy. General Motors. 15 p.
  • Dauphin-Ducharme, P., Mauzeroll, J. (2011). Simulation (2D) of corrosion at bi-metallic interfaces: UQÀM Validation report on existing GM model to 4.2 COMSOL version. General Motors. 20 p.

Articles de conférence

  • Ushula Mengesha Tefashe, Philippe Dauphin-Ducharme, Michael E. Snowden, Janine Mauzeroll. (2013). Correlation between microstructure and corrosion properties of die-cast AM50 magnesium alloy. Magnesium Technology, 1567-1573. (Article publié).
  • Philippe Dauphin-Ducharme, Janine Mauzeroll. (2013). Monitoring magnesium cation release dynamics during magnesium alloy corrosion using potentiometric Mg2+ ion-selective microelectrode. Magnesium Technology, 1470-1471. (Article publié).
  • Dao Trinh, Philippe Dauphin-Ducharme, Ushula Mengesha Tefashe, Joseph R. Kish, Janine Mauzeroll. (2013). Studying magnesium alloys using scanning electrochemical microscopy. Magnesium Technology, 1472-1473. (Article publié).

Propriétés intellectuelles

Brevets

  • Hui Li, Philippe Dauphin Ducharme, Gabriel Ortega, Kevin W. Plaxco. Calibration-free Electrochemical Biosensors. US 62/513,796. États-Unis. (En instance).
  • Mauzeroll, J.; Noyhouzer, T. A.; Snowden, M. E.; Dauphin Ducharme, P.; Mazurkiewicz, S.; L'homme, C.; Desjardins, S.; Canesi, S. Redox Triggered Vesicles. US 62/105,039. États-Unis. (Délivré).

Autres contributions

Cours enseignés

  • Organic Chemistry I. CHEM 211. (2012-01-10 à 2012-04-13).McGill University. Canada.

Gestion d'évènements

  • Chair. (2015) 5th Montreal ECS Student Chapter Symposium. (Conférence).
  • Chair. (2014) 4th Montreal ECS Student Chapter Symposium. (Conférence).
  • Vice-Chair. (2013-2014) 3rd Montreal ECS Student Chapter Symposium. (Conférence).

Présentations

  • (2019). In Vein and In Brain Detection of Drugs using DNA Biosensors. 102nd Canadian Chemistry Conference and Exhibition. Quebec, Canada
  • (2019). In Vein and In Brain Detection of Drugs using DNA Biosensors. 70th Annual Meeting of the International Society of Electrochemistry. Durban, Afrique du Sud
  • (2018). Biology-Inspired Real-Time Monitoring of Drugs in the Living Body using Aptamer-Based Electrochemical Biosensors. Canadian Society of Chemistry. Edmonton, Canada
  • (2018). Engineering Aptamers to Maximize their Analytical Performance using a Thermodynamic Approach Towards Real-Time Monitoring of Drugs in the Living Body. American Chemical Society National Meeting. Boston, États-Unis
  • (2017). Calibration-free Electrochemical DNA Biosensors. Canadian Society of Chemistry. Toronto, Canada
  • (2017). Determination of Electron Transfer Rates in Self-Assembled DNA Monolayers. Canadian Society of Chemistry. Toronto, Canada
  • (2015). Magnesium Alloys Corrosion Studied by Scanning Electrochemical Microscopy. Canadian Society of Chemistry. Ottawa, Canada
  • (2015). New Insights into Magnesium Alloy Corrosion using Scanning Electrochemcial Microscopy. American Chemical Society National Meeting. Denver, États-Unis
  • (2014). New Insights in Magnesium Alloys Corrosion. Centre Québecois sur les Matériaux Fonctionnels. Shawinigan, Canada
  • (2013). Monitoring Magnesium Alloys Corrosion Using Scanning Probe Techniques. Canadian Society of Chemistry. Quebec, Canada
  • (2013). Monitoring Magnesium Cation Release Dynamics during Magnesium Alloy Corrosion Using Potentiometric Mg2+ Ion-selective Microelectrode. METSOC. Montreal, Canada
  • (2013). Monitoring Magnesium Cation Release Dynamics during Magnesium Alloy Corrosion Using a Potentiometric Mg2+ Ion-selective Microelectrode. Surface Canada. London, Canada
  • (2012). SECM study of Mg alloys galvanicaly coupled to steel and aluminum alloys to develop anti-corrosion mechanism for their industrial applications. NACE Northern Area Eastern Conference. Toronto, Canada