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Sherif Abou Elela

Professeur, Faculté de médecine et des sciences de la santé
FMSS Dép. de microbiologie et infectiologie

Présentation

Sujet de recherche

Cell, Gene (Living Organisms), Metabolism (Living Organisms), Microorganisms, Protist

Disciplines de recherche

Biology and Related Sciences

Mots-clés

cancer, dsRNA, Ribosome, RNA binding proteins, RNA maturation, RNA recognition, RNase III, snoRNA, Splicing, Yeast

Intérêts de recherche

RNA processing and stability play an important role in the regulation of gene expression. By studying factors regulating RNA stability and processing we aim at generating an integrated view of the mechanism controlling conditional RNA decay, provide a model to test in mammals and use this information as tools for diagnosis and treatment of human disease.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(1997). (Post-doctorate, Postdoc). University of California, Santa Cruz.

(1994). (Doctorate, Doctor of Philosophy in). University of Guelph.

(1987). (Bachelor's, Bachelor of Science). University of Qatar.

Publications

Articles de revue

  • Madgwick A, Fort P, Hanson PS, Thibault P, Gaudreau MC, Lutfalla G, Möröy T, Abou Elela S, Chaudhry B, Elliott DJ, Morris CM, Venables JP. (2015). Neural differentiation modulates the vertebrate brain specific splicing program. PLoS One 10 (5), e0125998. (Published).
  • Gagnon J, Lavoie M, Catala M, Malenfant F, Elela SA. (2015). Transcriptome Wide Annotation of Eukaryotic RNase III Reactivity and Degradation Signals. PLoS Genet. 11 (2), e1005000. (Published).
  • Deschamps-Francoeur G, Garneau D, Dupuis-Sandoval F, Roy A, Frappier M, Catala M, Couture S, Barbe-Marcoux M, Abou-Elela S, Scott MS. (2014). Identification of discrete classes of small nucleolar RNA featuring different ends and RNA binding protein dependency. Nucleic Acids Res 54 (3), 10073-85. (Published).
  • Liang YH, Lavoie M, Comeau MA, Abou Elela S, Ji X. (2014). Structure of a eukaryotic RNase III postcleavage complex reveals a double-ruler mechanism for substrate selection. Mol Cell. 54 (3), 431-44. (Published).
  • Brosseau JP , Lucier JF , Lamarche AA , Shkreta L , Gendron D , Lapointe E , Thibault P , Paquet E , Perreault JP , Abou Elela S , Chabot B. (2014). Redirecting splicing with bifunctional oligonucleotides. Nucleic acids research 42 (6), e40. (Published).
  • Liang YH , Lavoie M , Comeau MA , Abou Elela S , Ji X. (2014). Structure of a Eukaryotic RNase III Postcleavage Complex Reveals a Double-Ruler Mechanism for Substrate Selection. Molecular cell 54 (3), 431-44. (Published).
  • Brosseau JP , Lucier JF , Nwilati H , Thibault P , Garneau D , Gendron D , Durand M , Couture S , Lapointe E , Prinos P , Klinck R , Perreault JP , Chabot B , Abou-Elela S. (2014). Tumor microenvironment-associated modifications of alternative splicing. RNA (New York, N.Y.) 20 (2), 189-201. (Published).
  • Dionne I , Larose S , Dandjinou AT , Abou Elela S , Wellinger RJ. (2013). Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA. RNA (New York, N.Y.) 19 (7), 992-1002. (Published).
  • Shkreta L , Bell B , Revil T , Venables JP , Prinos P , Elela SA , Chabot B. (2013). Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing. Cancer treatment and research 158 41-94. (Published).
  • Venables JP , Lapasset L , Gadea G , Fort P , Klinck R , Irimia M , Vignal E , Thibault P , Prinos P , Chabot B , Abou Elela S , Roux P , Lemaitre JM , Tazi J. (2013). MBNL1 and RBFOX2 cooperate to establish a splicing programme involved in pluripotent stem cell differentiation. Nature communications 4 4:2480. (Published).
  • Venables JP , Brosseau JP , Gadea G , Klinck R , Prinos P , Beaulieu JF , Lapointe E , Durand M , Thibault P , Tremblay K , Rousset F , Tazi J , Abou Elela S , Chabot B. (2013). RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Molecular and cellular biology 33 (2), 396-405. (Published).
  • Catala M , Aksouh L , Abou Elela S. (2012). RNA-dependent regulation of the cell wall stress response. Nucleic acids research 40 (15), 7507-17. (Published).
  • Noël JF , Larose S , Abou Elela S , Wellinger RJ. (2012). Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway. Nucleic acids research 40 (12), 5625-36. (Published).
  • Lund N , Milev MP , Wong R , Sanmuganantham T , Woolaway K , Chabot B , Abou Elela S , Mouland AJ , Cochrane A. (2012). Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression. Nucleic acids research 40 (8), 3663-75. (Published).
  • Michelle L , Cloutier A , Toutant J , Shkreta L , Thibault P , Durand M , Garneau D , Gendron D , Lapointe E , Couture S , Le Hir H , Klinck R , Elela SA , Prinos P , Chabot B. (2012). Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators. Molecular and cellular biology 32 (5), 954-67. (Published).
  • Ghazal G , Gagnon J , Elela SA. (2012). Detection and characterization of transcription termination. Methods in molecular biology (Clifton, N.J.) 809 593-607. (Published).
  • Catala M, Aksouh L, Abou Elela S. (2012). RNA-dependent regulation of the cell wall stress response. Nucleic Acids Research 40 (May 10), 7507-17. (Published).
  • Lavoie M , Ge D , Abou Elela S. (2012). Regulation of conditional gene expression by coupled transcription repression and RNA degradation. Nucleic acids research 40 (2), 871-8. (Published).
  • Meaux S , Lavoie M , Gagnon J , Abou Elela S , van Hoof A. (2011). Reporter mRNAs cleaved by Rnt1p are exported and degraded in the cytoplasm. Nucleic acids research 39 (21), 9357-67. (Published).
  • Parenteau J , Durand M , Morin G , Gagnon J , Lucier JF , Wellinger RJ , Chabot B , Elela SA. (2011). Introns within ribosomal protein genes regulate the production and function of yeast ribosomes. Cell 147 (2), 320-31. (Published).
  • Prinos P , Garneau D , Lucier JF , Gendron D , Couture S , Boivin M , Brosseau JP , Lapointe E , Thibault P , Durand M , Tremblay K , Gervais-Bird J , Nwilati H , Klinck R , Chabot B , Perreault JP , Wellinger RJ , Elela SA. (2011). Alternative splicing of SYK regulates mitosis and cell survival. Nature structural & molecular biology 18 (6), 673-9. (Published).
  • Tanackovic G , Ransijn A , Thibault P , Abou Elela S , Klinck R , Berson EL , Chabot B , Rivolta C. (2011). PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Human molecular genetics 20 (11), 2116-30. (Published).
  • Bergeron L , Perreault JP , Abou Elela S. (2010). Short RNA duplexes guide sequence-dependent cleavage by human Dicer. RNA (New York, N.Y.) 16 (12), 2464-73. (Published).
  • Brosseau JP , Lucier JF , Lapointe E , Durand M , Gendron D , Gervais-Bird J , Tremblay K , Perreault JP , Elela SA. (2010). High-throughput quantification of splicing isoforms. RNA (New York, N.Y.) 16 (2), 442-9. (Published).
  • Ghazal G , Gagnon J , Jacques PE , Landry JR , Robert F , Elela SA. (2009). Yeast RNase III triggers polyadenylation-independent transcription termination. Molecular cell 36 (1), (Published).
  • Alló M , Buggiano V , Fededa JP , Petrillo E , Schor I , de la Mata M , Agirre E , Plass M , Eyras E , Elela SA , Klinck R , Chabot B , Kornblihtt AR. (2009). Control of alternative splicing through siRNA-mediated transcriptional gene silencing. Nature structural & molecular biology 16 (7), (Published).
  • Venables JP , Klinck R , Koh C , Gervais-Bird J , Bramard A , Inkel L , Durand M , Couture S , Froehlich U , Lapointe E , Lucier JF , Thibault P , Rancourt C , Tremblay K , Prinos P , Chabot B , Elela SA. (2009). Cancer-associated regulation of alternative splicing. Nature structural & molecular biology 16 (6), 670-6. (Published).

Chapitres de livre

  • Lulzim Shkreta, Brendan Bell, Timothée Revil, Julian P. Venables, Panagiotis Prinos, Sherif Abou Elela, Benoit Chabot. (2013). Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing. RNA and Cancer (158, 41-94). Springer-Verlag Berlin Heidelberg. (In Press).
  • Ghazal G, Gagnon J, Elela SA. (2012). Detection and Characterization of Transcription Termination. Methods in Molecular Biology (593-607). Humana Press/Springer. (Published).
  • Roscoe Klinck, Benoit Chabot andSherif Abou Elela. (2011). High-throughput analysis of alternative splicing by RT-PCR. Methods of Alternative Splicing (239-246). Wiley, Hoboken, NJ. (Published).

Propriétés intellectuelles

Patents

  • (2014). Methods to reprogram splice site selection in premessenger RNAs. The field of the invention is interference with splice site selection required for the generation of mRNAs encoding functional proteins. AA61K4800FI. (Completed).
  • (2011). Signature of secreted protein isoforms specific to ovarian cancer. The field of invention is cancer biomarkers. PCT/CA2010/000570. (Completed).
  • Alternative splicing gene variants in cancer detection. PCT/CA2008/001477. (In Progress).

Autres contributions

Gestion d'évènements

  • Organisateur. Ribo Club. (Conference).