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Denis Blondin

Professeur, Faculté de médecine et des sciences de la santé
FMSS Département de médecine

Présentation

Sujet de recherche

Diabetes, Metabolic Disorders, Environmental Health

Disciplines de recherche

Endocrinology, Physiology

Mots-clés

Positron emission tomography, Diabetes, Obesity, Cold Exposure, Metabolism, Stable Isotope Methods, Indirect Calorimetry, Thermoregulation, Exercise Physiology, Nutrition, Heat Exposure

Intérêts de recherche

Thermogenesis Energy metabolism Cardiometabolism Energy metabolism

Centre de recherche

Centre de recherche du CHUS

Recherche clinique

Yes

Langues parlées et écrites

Anglais, Français

Diplômes

(2014). Thermogenesis and Fuel Selection during Cold Exposure: Tissue-Specific Metabolism and Cold-Acclimation. (Doctorate, Doctorate in Human Kinetics). University of Ottawa.

(2008). The effect of carbohydrate ingestion type and timing on substrate utilization during low-intensity shivering (Master's Thesis, Masters of Science). University of Ottawa.

(2004). (Bachelor's, Bachelor's of Science). University of Ottawa.

Titres de compétence

(2012) Certified Exercise Physiologist.

Expérience académique

Assistant professor. (2019-). Université de Sherbrooke. Canada.

Researcher. (2019-). Centre Hospitalier Univ. de Sherbrooke. Canada.

Adjunct professor. (2019-2019). Université de Sherbrooke. Canada.

Postdoctoral fellow. (2017-2018). University of Ottawa. Canada.

Postdoctoral fellow. (2014-2017). Université de Sherbrooke. Canada.

Research Assistant/PhD Student. (2008-2013). University of Ottawa. Canada.

Teaching Assistant. (2004-2012). University of Ottawa. Canada.

Prix et distinctions

  • (2024) Research Scholar Junior 1. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2017) CIHR Postdoctoral Fellowship. Canadian Institutes of Health Research. (Prize / Award).
  • (2012) Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship. Natural Sciences and Engineering Research Council of Canada (NSERC). (Prize / Award).
  • (2012) University of Ottawa Excellence Scholarship. University of Ottawa. (Prize / Award).
  • (2009) Ontario Graduate Scholarship. Government of Ontario. (Prize / Award).
  • (2009) Ontario Graduate Scholarship in Science and Technology. Government of Ontario. (Prize / Award).
  • Best oral presentation - Congrès de la Société Québécoise de lipidologie, de nutrition et de métabolism/Réseau de recherche en santé cardiométabolique, diabète et obésité/COLosSUS. Société Québécoise de lipidologie, de nutrition et de métabolism/Réseau de recherche en santé cardio. (Prize / Award).
  • Best oral presentation - Congrès de la Société Québécoise de lipidologie, de nutrition et de métabolism/Réseau de recherche en santé cardiométabolique, diabète et obésité/COLosSUS. Société Québécoise de lipidologie, de nutrition et de métabolism/Réseau de recherche en santé cardio. (Prize / Award).
  • Best oral presentation - Montreal Diabetes Research Center Annual Retreat. Montreal Diabetes Research Center. (Prize / Award).
  • Bourses de recherche postdoctorale du centre de recherche clinique Étienne-Le Bel. Centre Hospitalier Univ. de Sherbrooke. (Prize / Award).
  • Highly Cited Paper in 2017. Journal of Physiology - London. (Citation).
  • James Willerson Young Investigator Award in Cardiovascular Medicine. International Academy of Cardiovascular Sciences. (Prize / Award).
  • Nominated by Department of Human Kinetics for The Commission on graduate studies in sciences prize. University of Ottawa. (Distinction).
  • Nominated for Governor general's gold medal. University of Ottawa. (Distinction).
  • Researcher of the month - Centre de recherche du Centre hospitalier universitaire de Sherbrooke. Centre Hospitalier Univ. de Sherbrooke. (Honor).
  • Travel Award - NIH/NIDDK symposium - Exploring the Roles of Brown Fat in Humans. National Institutes of Health. (Prize / Award).
  • Turku Collegium for Science and Medicine Postdoctoral Fellowship (declined). University of Turku. (Prize / Award).
  • University of Ottawa Faculty of Graduate and Post-Doctoral Studies Research Travel Grant. University of Ottawa. (Prize / Award).
  • University of Ottawa Faculty of Graduate and Post-doctoral Studies Conference Travel Grant. University of Ottawa. (Prize / Award).

Financement

  • Grant. (Under Review). Co-applicant. The impact of estrogen status on the biological function of brown adipose tissue in women measured using quantitative PET/CT.. National Institutes of Health (NIH) (USA). R01. 572 624 $. (2023-2028)
  • Grant. (Awarded). Principal Applicant. Training platform in diabetes, obesity and cardiometabolic health. Canadian Institutes of Health Research (CIHR). Training Grant: Health Research Training Platform. 2 400 000 $. (2022-2027)
  • Contract. (Awarded). Principal Applicant. Tirzepatide Study of Renal Function in People with Overweight or Obesity and Chronic Kidney Disease with or without Type 2 Diabetes: Focus on Kidney Hypoxia in Relation to Fatty Kidney Disease using Multiparametric Magnetic Resonance Imaging.. Eli Lilly & Co (USA). 561 540 $. (2022-2026)
  • Grant. (Awarded). Principal Applicant. The Right Timing to prevent Type 2 Diabetes: Restoring 24-hour substrate rhythmicity to improve glycemic control by timing of lifestyle factors.. Canadian Institutes of Health Research (CIHR). Team Grant : Netherlands-Canada Type 2 Diabetes Research Consortium. 1 999 783 $. (2021-2026)
  • Grant. (Awarded). Principal Applicant. Caractérisation de la thermogenèse médiée par le cycle du calcium chez les rongeurs et les humains.. Fonds de recherche du Québec - Nature et technologies (FRQNT). NOVA. 273 704 $. (2022-2025)
  • Grant. (Awarded). Co-applicant. Bio-Behavioral and Morphologic Predictors of Resilience During Cold Weather and Arctic Operations.. Office of Naval Research. Naval International Cooperative Opportunities in Science and Technology. 540 000 $. (2021-2024)
  • Research Chair. (Awarded). Principal Applicant. Pathogenèse du DT2 et dysfonction des tissus maigres.. Université de Sherbrooke. GSK Research Chair in Diabetes. 250 000 $. (2019-2024)
  • Grant. (Awarded). Principal Applicant. La thermogenèse musculaire et son potentiel thérapeutique contre le développement du diabète de type 2.. Fonds de recherche du Québec - Santé (FRQS). Research Scholar Junior 1. 246 321 $. (2020-2024)
  • Grant. (Awarded). Principal Applicant. La thermogenèse musculaire et son potentiel thérapeutique contre le développement du diabète de type 2.. Fonds de recherche du Québec - Santé (FRQS). Subvention d’établissement de jeune chercheur. 80 000 $. (2020-2024)
  • Grant. (Awarded). Principal Applicant. Metabolic phenotyping in the prevention and pathophysiology of metabolic diseases. Canada Foundation for Innovation (CFI). John R. Evans Leaders Fund. 917 443 $. (2022-2024)
  • Grant. (Awarded). Principal Applicant. Human skeletal muscle thermogenesis and plasticity in response to various environmental conditions. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grants. 140 000 $. (2019-2024)
  • Grant. (Awarded). Co-investigator. Measuring metabolically active kidney tissue in autosomal dominant polycystic kidney disease.. National Institutes of Health (NIH) (USA). Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases. 200 000 $. (2021-2023)
  • Grant. (Awarded). Principal Applicant. Combating diabetes by turning up the heat: cold exposure as an adjunct therapeutic strategy in individuals with prediabetes?. Diabète Québec. Subventions en recherche fondamentale, clinique et appliquée dans le domaine du diabète. 20 000 $. (2022-2023)
  • Grant. (Awarded). Co-investigator. Métabolisme énergétique du coeur septique. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Programme projets structurants CRCHUS. 75 000 $. (2022-2023)
  • Grant. (Awarded). Co-applicant. Energy MEtabolism of Septic Heart (eMESH)/ Métabolisme Énergétique du Coeur Septique (MECS). Sepsis Canada/CMDO. 40 000 $. (2022-2023)
  • Grant. (Awarded). Principal Applicant. Clinical implications of heat and cold exposure.. Fonds Institutionnel de Recherche de l'Université de Sherbrooke. Fonds Institutionel. 70 000 $. (2019-2022)
  • Grant. (Awarded). Principal Applicant. Investigating therapeutic potential of thermogenic processes in cold exposed humans.. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Start-up grant. 95 000 $. (2019-2022)
  • Grant. (Awarded). Co-investigator. CROCODILE: Control of Renal Oxygenation COnsumption, mitochondrial Dysfunction and InsuLin rEsistance.. Juvenile Diabetes Research Foundation. Pilot & Feasibility Program. 100 000 $. (2019-2022)
  • Grant. (Awarded). Principal Applicant. Acute and chronic effects of heat exposure on cardiometabolic functions in adults with type 2 diabetes.. Fonds de Recherche du Québec - Santé, Research Network on Cardiometabolic Health, Diabetes and Obes. Intercenter Structuring Initiatives. 40 000 $. (2021-2022)
  • Grant. (Awarded). Co-applicant. Rôle des récepteurs adrénergiques dans la progression de la stéatose hépatique.. Fonds de Recherche du Québec - Santé,Research Network on Cardiometabolic Health, Diabetes and Obesit. Intercenter Structuring Initiatives. 40 000 $. (2021-2022)
  • Grant. (Awarded). Collaborator. Gene Environment Team on Brown/beige Adipose Tissue. Canadian Institutes of Health Research (CIHR). Team grant. 1 988 323 $. (2016-2021)
  • Grant. (Awarded). Principal Applicant. Sympathomimetics and Sympatholytics in Type 2 Diabetes: Teaching Old Drugs New Tricks.. Réseau québecois de recherche sur les médicaments. Projet Fédérateur. 70 000 $. (2020-2021)
  • Grant. (Awarded). Co-investigator. The impact of estrogen status on the biological function of brown adipose tissue in women measured using quantitative PET/CT. National Institutes of Health (NIH) (USA). Exploration of the Roles of Brown and Beige Adipose Tissue in Humans. 824 791 $. (2016-2021)
  • Grant. (Completed). Principal Applicant. Human skeletal muscle thermogenesis and plasticity in response to various environmental conditions.. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Launch Supplement. 12 500 $. (2019-2021)
  • Grant. (Completed). Co-applicant. Rôle de la protéine SRSF3 liant l’ARNm dans la pathogenèse de la cardiomyopathie diabétique.. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Concours de subvention de l’Axe-Thème et du CEUS DOCC (CRCHUS). 10 000 $. (2020-2021)
  • Grant. (Completed). Principal Applicant. Impact de l’infusion d’ELABELA sur le métabolisme énergétique du coeur septique expérimental en imagerie TEP et la respiration mitochondriale en analyse OROBOROS. Centre de recherche du Centre hospitalier universitaire de Sherbrooke. Concours de subvention de Axe-thème Diabètes, Obésité et Complications Cardiométaboliques. 10 000 $. (2019-2020)
  • Grant. (Completed). Co-investigator. Impact de l’infusion d’apéline sur le métabolisme énergétique du cœur septique expérimental en imagerie TEP.. Réseau de Bio-imagerie du Québec - Réseau de recherche en santé cardiométabolique, diabète et obésit. Initiatives Inter-Réseau (Réseau CMDO et RBIQ). 19 994 $. (2019-2020)
  • Grant. (Completed). Principal Applicant. The Netherlands-Canada Type 2 Diabetes Research Consortium: The Right Timing to Prevent and Treat Type 2 Diabetes (T2D).. Canadian Institutes of Health Research (CIHR). The Netherlands-Canada Type 2 Diabetes Research Consortium Travel Award. 3 000 $. (2019-2019)
  • Grant. (Completed). Co-applicant. Optimizing performance and health readiness of CF Solders during cold extremes: an international partnership. National Defence (Canada). Innovation for Defence Excellence and Security. 198 366 $. (2018-2019)
  • Contract. (Completed). Co-investigator. The relationship between shivering onset measured by surface electromyography (EMG) and by electrocardiography (EKG) during compensable cold exposure.. C. R. Bard Inc. (USA). C. R. Bard Inc. (USA). 125 177 $. (2017-2018)
  • Grant. (Completed). Co-applicant. Développement d’un système automatisé de clamp de la température cutanée compatible à l’IRM.. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Programme de projets pilotes express de l'Axe d'imagerie médicale du CRCHUS et du CIMS. 10 000 $. (2018-2018)
  • Contract. (Completed). Collaborator. Effects of maple syrup on sport performance. Fédération des producteurs acéricoles du Québec. Fédération des producteurs acéricoles du Québec. 500 000 $. (2017-2017)
  • Contract. (Awarded). Principal Investigator. Assessing biomarkers associated to changes in energy expenditure related to cold exposure in humans.. Novo Nordisk A/S (Danemark). 172 988 $. (2023)

Publications

Articles de revue

  • Wang D, DesOrmeaux G, Frangos S, Dumont L*, Townsend L, Kuhre R, Ahmadi E, Batchuluun B, Gautam J, Jabile MJT, Rehal S, Desjardins E, Tsakiridis E, Lally J, Tupling AR, Gerstein H, Pare G, Tsakiridis T , Blondin DP, Holloway G, Jørgensen S, Steinberg G. (2022). A GDF15-GFRAL-beta adrenergic signaling axis increases energy expenditure during caloric restriction. Nature (Submitted).
  • Carpentier AC, Blondin DP, Haman F, Richard D. (2022). Brown adipose tissue - a translational perspective. Endocrine Reviews (In Press).
  • Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet E, Haman F, Cuperlovic-Culf M, McPherson R, Dent R, and Harper M-E. (2022). Exercise training preferentially enhances skeletal muscle metabolism in diet-resistant obesity. eBioMedicine (Accepted).
  • Richard G, Blondin DP, Syed SA, Fontes ME, Fortin M, Phoenix S, Frisch F, Dubreaul S, Guérin B, Turcotte EE, Lepage M, Surette MG, Schertzer JD, Steinberg GR, Morrison KM, Carpentier AC. (2022). High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake in young men independently of changes in thermogenesis and the gut microbiome. Cell Reports Medicine (Accepted).
  • Ahmed BA, Varah N, Ong FJ, Blondin DP, Gunn E, Konyer NB, Singh NP, Noseworthy MD, Haman F, Carpentier AC, Punthakee Z, Steinberg GR, Morrison KM. (2022). Impaired cold stimulated supraclavicular brown adipose tissue activity in young boys with obesity. Diabetes 71 (6), 1193-1204. (Published).
  • Sesbreno E, Blondin DP, Dziedzic C, Sygo J, Haman F, Leclerc S., Brazeau A-S , and Mountjoy M. (2022). Signs of low energy availability in elite male volleyball athletes but low rate of bone injury and no association with the Victorian Institute of Sport Assessment questionnaire – patellar tendon score. European Journal of Sport Science (Submitted).
  • Sesbreno E, Dziedzic C, Blondin DP, Kennedy C, Sygo J, Haman F, Deslauriers J, Brazeau A-S and Mountjoy M. (2022). The association of low energy availability on countermovement jumping and executive function in elite male volleyball players. Applied Physiology, Nutrition and Metabolism (Submitted).
  • Dumont L, Lessard R, Semeniuk K, Chahrour H, McCormick J.J., Acosta FM, Blondin DP and Haman F. (2022). Thermogenic responses to different clamped skin temperatures in cold-exposed men and women. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 323 (1), R149-R160. (Published).
  • Ahmed BA, Ong FJ, Barra NG, Blondin DP, Gunn E, Oreskovich SM, Szamosi JC, Hutchings EK, Konyer NB, Singh NP, Syed SA, Yabut JM, Desjardins EM, Anhê FF, Foley KP, Holloway AC, Noseworthy MD, Haman F, Carpentier AC, Surrette MG, Scherzer JD, Punthakee Z, Steinberg GR, Morrison KM. (2021). Adult humans with higher liver fat have lower cold-stimulated brown adipose tissue activity without related changes in the gut microbiota. Cell Reports - -. (Revision Requested).
  • Ahmed BA, Varah N, Ong FJ, Gunn E, Yabut JM, Blondin DP, Konyer NB, Singh NP, Noseworthy MD, Haman F, Carpentier AC, Punthakee Z, Steinberg G, Morrison KM. (2021). Boys with obesity have low concentrations of 5 hydroxy-indole acetic acid (5HIAA) in the urine. Journal of pediatric obesity - -. (Submitted).
  • Blondin DP, Haman F, Swibas TM, Guertin J*, Hogan-Lamarre S*, Weissenburger Q*, Hildreth KL, Boxer RS, Carpentier AC, Miao Y, Wick T, Juarez-Colunga E, MacLean PS, Kohrt WM, Melanson EL. (2021). Brown Adipose Tissue Activity in Premenopausal and Postmenopausal Womenis Associated with Ovarian Function. Journal of Clinical Endocrinology & Metabolism - (-), -. (Revision Requested).
  • Dumont AA, Dumont L, Zhou D, Giguère H, Pileggi C, Harper ME, Blondin DP, Scott M, Auger-Messier M. (2021). Cardiomyocyte specific Srsf3 deletion uncovers its regulatory role on mitochondrial function. FASEB 35 (5), e21544. (Published).
  • Löffler MC, Betz MJ, Blondin DP, Augustin R, Scharma AK, Tseng YH, Scheele C, Zimdahl H, Mark M, Hennige AA, Wolfrum C, Langhans W, Hamilton BS, Neubauer H. (2021). Challenges in tackling energy expenditure as obesity therapy A perspective review on energy expenditure from preclinical models to clinical application. Molecular Metabolism - -. (In Press).
  • Richard G, Noll C, Archambault M, Lebel R, Tremblay L, Ait-Mohand S, Guérin B, Blondin DP, Carpentier AC, Lepage M. (2021). Contribution of perfusion to the 11C-acetate signal in brown adipose tissue assessed by DCE-MRI and 68Ga-DOTA PET in a rat model. Magnetic Resonance in Medicine 85 (3), 1625-1642. (Published).
  • Sesbreno, E, Dziedzic CE, Sygo J, Blondin DP, Haman F, Leclerc S, Brazeau A-S, Mountjoy M. (2021). Elite Male Volleyball Players are at Risk of Insufficient Energy and Carbohydrate Intake. Nutrients - -. (Accepted).
  • Ivanova YM*, Blondin DP. (2021). Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes. Journal of Applied Physiology - -. (In Press).
  • Ahmed BA, Ong FJ, Barra NG, Blondin DP, Gunn E, Oreskovich SM, Szamosi JC, Syed SA, Hutchings EK, Konyer NB, Singh NP, Yabut JM, Desjardins EM, Anhê FF, Foley KP, Holloway AC, Noseworthy MD, Haman F, Carpentier AC, Surette MG, Schertzer JD, Punthakee Z, Steinberg GR, Morrison KM. (2021). Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota. Cell Reports Medicine 2 (9), 100397. (Published).
  • Carreau A-M, Noll C, Blondin DP, Frish F, Nadeau M, Pelletier M, Phoenix S, Cunnane SC, Guérin B, Turcotte EE, Biertho L, Tchernof A, Carpentier AC. (2020). Bariatric surgery rapidly decreases cardiac dietary fatty acid partitioning and hepatic insulin resistance through increased intra-abdominal adipose tissue storage and reduced spillover in type 2 diabetes. Diabetes 69 (4), 567-577. (Published).
  • Richard MA, Pallubinsky H*, Blondin DP. (2020). Functional characterization of human brown adipose tissue metabolism. Biochemical Journal 477 (7), 1261-1286. (Published).
  • Blondin DP, Nielsen S, Kuipers EN, Severinsen MC, Jensen VH, Miard S, Jespersen NZ, Kooijman S, Boon MR, Fortin M, Phoenix S, Frisch F, Guérin B, Turcotte ÉE, Haman F, Richard D, Picard F, Rensen PCN, Scheele C, Carpentier AC. (2020). Human BAT thermogenesis is stimulated by the β₂-adrenergic receptor. Cell Metabolism 32 (2), 287-300. (Published).
  • Oreskovich SM, Ong FJ, Ahmed BA, Konyer NB, Blondin DP, Gunn E, Singh NP, Noseworthy MD, Haman F, Carpentier AC, Punthakee Z, Steinberg GR, Morrison KM. (2019). MRI reveals human brown adipose tissue is rapidly activated in response to cold. Journal of the Endocrine Society 14 (3), 2374-2384. (Published).
  • Richard MA, Blondin DP, Noll C, Level R, Lepage M, Carpentier AC. (2019). Pharmacokinetic modeling of [11C]-acetate in brown adiposetissue: model determination and challenges. European Journal of Nuclear Medicine and Molecular Imaging 9 (1), 31. (Published).
  • Acosta FM*, Martinez-Tellez B, Blondin DP, Haman F, Rensen PCN, Martinez-Nicolas A, Ruiz JR. (2019). Relationship between distal skin temperature daily rhythm and brown adipose tissue 18F-Fluordeoxyglucose uptake in young adults. Journal of Biological Rhythms 34 (5), 533-550. (Published).
  • Gordon K, Blondin DP, Friesen B, Tingelstad HC, Kenny GP, and Haman F. (2019). Seven days of cold acclimation substantially increases nonshivering thermogenesis in adult humans. Journal of Applied Physiology 126 (6), 1598-1606. (Published).
  • Acosta FM*. Sánchez Delgado G, Martínez-Téllez B. Hidalgo Migueles J; Amaro Gahete FJ, Rensen PCN; Llamas Elvira JM, Blondin DP, Ruiz J. (2019). Sleep duration and quality are not associated with brown adipose tissue volume or activity - as determined by 18F-FDG uptake, in young, sedentary adults. Sleep 42 (12), zsz177. (Published).
  • Carpentier AC, Blondin DP, Virtanen KA, Richard D, Haman F, Turcotte EE. (2018). Brown adipose tissue energy metabolism in humans. Frontiers in Endocrinology 9 1-21. (Published).
  • Ong FJ, Ahmed B, Oreskovich S, Blondin DP, Haq T, Konyer N, Noseworthy MD, Haman F, Carpentier AC, Morrison KM, Steinberg GR. (2018). Recent advances in the detection of brown adipose tissue in adult humans: a review. Clinical Science (London) 132 (10), 1039-54. (Published).
  • Friesen BJ, Périard JD, Poirier MP, Lauzon M, Blondin DP, Haman F, Kenny GP. (2018). Work rate during self-paced exercise is not mediated by the rate of heatstorage. Medicine & Science in Sports & Exercise 50 (1), 159-168. (Published).
  • Blondin DP, Tingelstad HC, Noll C, Frisch F, Phoenix S, Guérin B, Turcotte EE, Richard D, Haman F, Carpentier AC. (2017). Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men. Nature Communications 8 14146. (Published).
  • Blondin DP, Daoud A, Taylor T, Tingelstad HC, Bézaire V, Richard D, Carpentier AC, Taylor AW, Harper M-E, Aguer C, Haman F. (2017). Four-week cold acclimation in adult humans shifts the ATPase-independent heat production from skeletal muscles to BAT. Journal of Physiology (London) 595 (6), 2099-2113. (Published).
  • Blondin DP, Frisch F, Phoenix S, Guérin B, Turcotte EE, Haman F, Richard D, Carpentier AC. (2017). Inhibition of intracellular triglyceride lipolysis suppresses cold-induced brown adipose tissue metabolism and increases shivering in humans. Cell Metabolism 25 (2), 438-447. (Published).
  • Haman F, Blondin DP. (2017). Shivering thermogenesis in humans: origin, contribution and metabolic requirements. Temperature 4 (3), 217-226. (Published).
  • O’Hearn K, Tingelstad HC, Blondin DP, Tang V, Filion LG, Haman F. (2016). Heat exposure increases circulating fatty acids but not lipid oxidation at rest and during exercise. Journal of Thermal Biology 55 39-46. (Published).
  • Haman F, Mantha OL, Cheung SS, Ducharme MB, Taber M, Blondin DP, McGarr GW, Hartley GL, Hynes Z, Basset FA. (2016). Oxidative fuel selection and shivering thermogenesis during a 12 and 24h cold survival simulation. Journal of Applied Physiology 120 (6), 640-648. (Published).
  • Blondin DP, Carpentier AC. (2016). The role of BAT in cardiometabolic disorders and aging. Best Practice and Research in Clinical Endocrinology and Metabolism 30 (4), 497-513. (Published).
  • Blondin DP, Labbé SM, Turcotte EE, Haman F, Richard D, Carpentier AC. (2015). A critical appraisal of brown adipose tissue in humans. Clinical Lipidology 10 (3), 259-280. (Published).
  • Blondin DP, Labbé SM, Noll C, Kunach M, Phoenix S, Guérin B, Turcotte EE, Haman F, Richard D, Carpentier AC. (2015). Selective impairment of glucose, but not fatty acid or oxidative metabolism in brown adipose tissue of subjects with type 2 diabetes. Diabetes 64 (7), 2388-2397. (Published).
  • Blondin DP, Labbé SM, Phoenix S, Guérin B, Turcotte EE, Richard D, Carpentier AC, Haman F. (2014). Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men. Journal of Physiology (London) 593 (3), 701-714. (Published).
  • Blondin DP , Labbé SM , Christian Tingelstad H , Noll C , Kunach M , Phoenix S , Guérin B , Turcotte EE , Carpentier AC , Richard D , Haman F. (2014). Increased brown adipose tissue oxidative capacity in cold-acclimated humans. The Journal of clinical endocrinology and metabolism 99 (3), E438-E446. (Published).
  • Blondin DP , Labbé SM , Christian Tingelstad H , Mantha O, Gosselin C, Haman F. (2014). Maintaining thermogenesis in cold-exposed humans: relying on multiple metabolic pathways. Comprehensive Physiology 4 (4), 1383–1402. (Published).
  • Ouellet V , Labbé SM , Blondin DP , Phoenix S , Guérin B , Haman F , Turcotte EE , Richard D , Carpentier AC. (2012). Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. The Journal of clinical investigation 122 (2), 545-552. (Published).
  • Blondin DP , Péronnet F , Haman F. (2012). Coingesting Glucose and Fructose in the Cold Potentiates Exogenous CHO Oxidation. Medicine & Science in Sports & Exercise 44 (9), 1706-1714. (Published).
  • Blondin DP , Maneshi A , Imbeault MA , Haman F. (2011). Effects of the menstrual cycle on muscle recruitment and oxidative fuel selection during cold exposure. Journal of Applied Physiology 111 (4), 1014-1020. (Published).
  • Blondin DP , Péronnet F , Haman F. (2010). Effects of ingesting [13C]glucose early or late into cold exposure on substrate utilization. Journal of applied physiology (Bethesda, Md. : 1985) 109 (3), 654-662. (Published).
  • Blondin DP , Dépault I , Imbeault P , Péronnet F , Imbeault MA , Haman F. (2010). Effects of two glucose ingestion rates on substrate utilization during moderate-intensity shivering. European journal of applied physiology 108 (2), 289-300. (Published).
  • Haman F , Blondin DP , Imbeault MA , Maneshi A. (2010). Metabolic requirements of shivering humans. Frontiers in bioscience (Scholar edition) 2 1155-1168. (Published).

Chapitres de livre

  • Blondin DP, Haman F. (2018). Chapter 10: Shivering and nonshivering thermogenesis in skeletal muscles. Romanovsky, AA.. Handbook of Clinical Neurology (156, 153-173). United States of America : Elsevier B.V. (Published).

Rapports

  • Haman, F Blondin, DP. (2019). Optimizing performance and health readiness of CF soldiers during cold extremes: an international partnership. Milestone II: Effects of body composition and morphology on heat production, shivering and thermal comfort during compensable cold exposure. National Defence. 29 p.
  • Haman F, Blondin, DP. (2008). Integrated Personal Cooling for Chemical-Biological Protective Undergarments. Allen-Vanguard Corp..

Articles de conférence

  • Guertin J*, Swibas T, Hogan-Lamarre S*, Haman F, Hildreth K, Miao Y, Kohrt W, Carpentier AC, Blondin DP, Melanson EL. (2021). Relationship Between Brown Adipose Tissue and Shivering in Cold-Exposed Humans. Experimental Biology 2021. (Published).
  • Ivanova YM*, Swibas T, Haman F, Hildreth K, Miao Y, Kohrt WM, Carpentier AC, Melanson EL, Blondin DP. (2021). Sex Disparities in Thermoregulatory and Metabolic Responses to Mild Cold Exposure Largely Explained by Differences in Body Mass and Body Surface Area. Endo 2021. (Published).
  • Raytchev, S*, Tingelstad HC, Blondin, DP, Haman, F. (2016). Cold Acclimation in Humans: Effects of Changes in Brown Fat on the Recruitment and Shivering Pattern of Superficial Muscles. FASEB, (Published).
  • Blondin DP, Noll C, Tingelstad H, Labbé SM, Guérin B, Turcotte EE, Richard D, Haman F, Carpentier AC. (2016). Organ-Specific Dietary Fatty Acid Uptake in Cold-Acclimated Humans. FASEB, (Published).
  • Blondin DP, Labbé SM, Noll C, Kunach M, Phoenix S, Guérin B, Turcotte EE, Carpentier AC, Richard D, Haman F. (2013). Daily cold exposure increases brown adipose tissue-derived thermogenesis in adult humans. Canadian Journal of Diabetes, s60-s61. (Accepted).
  • Aguer, C. Blondin, DP, Taylor, T., Taylor, AW., Harper, ME., Haman, F. (2013). Effet d’un mois d’acclimatation au froid sur le métabolisme du muscle squelettique. Diabetes & Metabolism, A49. (Published).
  • Blondin DP, Labbé SM, Richard D, Turcotte É, Carpentier AC, Haman F. (2011). Muscle recruitment and muscle-specific substrate uptake in cold-exposed humans evaluated by electromyography and positron emission tomography coupled to computed tomography (PET/CT). The Obesity Society, 29th Annual scientific meeting. (Accepted).
  • Ouellet V, Labbé SM, Blondin DP, Haman F, Turcotte EE, Richard D,Carpentier AC. (2010). Cold-activated brown adipose tissue metabolism in healthy men. The Obesity Society, 28th Annual scientific meeting. (Accepted).
  • Blondin DP, Ouellet V, Labbé SM, Carpentier AC, Richard D, Turcotte EE, Haman F. (2010). Cold exposure methodology for investigating brown adipose tissue activation in humans. The Obesity Society, 28th Annual scientific meeting. (Accepted).
  • Blondin DP, Robidoux M, Imbeault P, Blais J, O’hearn K, Kruemmel E, Seabert T, Pal S, Haman F. (2009). Effects of dietary behaviour on exogenous glucose kinetics in 2 Oji-Cree communities of northwestern Ontario. 1st National Obesity Summit. (Accepted).
  • Maneshi A, Blondin DP, Imbeault M-A, Haman F. (2008). Effects of the menstrual cycle on substrate utilization during low-intensity shivering. CSEP Annual Scientific Conference. (Accepted).
  • Blondin D.P., Imbeault P., Péronnet F., Haman F. (2008). Exogenous glucose oxidation during shivering: effects of carbohydrate ingestion timing and type. CSEP Annual Scientific Conference. (Accepted).
  • Dickson C, Haman F, Blondin DP, Dépault I, Imbeault P. (2008). Plasma interleukin-6 concentration increases in parallel to increased fuel utilization during cold exposure. European Congress on Obesity. (Accepted).
  • Blondin D.P., Péronnet F., Imbeault P., and Haman F. (2008). The Effects of CHO Feeding on Fuel Selection During Low-Intensity Shivering. 13th annual congress of the European College of Sport Science. (Accepted).
  • Hogan-Lamarre S*, Swibas T, Guertin J*, Haman F, Hildreth K, Miao Y, Kohrt W, Carpentier AC, Blondin DP, Melanson EL. Brown Adipose Tissue Volume and Distribution in Premenopausal and Postmenopausal Women. Experimental Biology 2021. (Published).

Autres contributions

Cours enseignés

  • External Influences and Physical Activity. APA4315. (2018-01-01 à 2018-04-30).(3CR).

Gestion d'évènements

  • Co-organizer. Recent Advances & Controversies in the Measurement of Energy Metabolism. (Conference).
  • Organiser. (2008) Human physiology journal club. (Club).

Activités de collaboration internationale

  • Research collaboration. Denmark. Quantifying the thermogenic and lipolytic response of human primary brown adipocytes to beta-adrenergic stimulations.
  • Research collaboration. Spain. Examining differences in thermoregulatory responses to acute and chronic cold exposure in Canadian vs. Spanish residents. Examining circadian rhythm of mean skin temperature and its response tometabolic heat production and BAT activity.
  • Research collaboration. Finland. Examining the relationship between muscle blood flow, oxidative metabolism and uptake of circulating substrates in cold-exposed humans. Consulting on improvements to cold exposure protocols.
  • Research collaboration. Netherlands.
  • Research collaboration. United States of America. Examining the impact of estrogen status on thebiological function of brown adipose tissue (BAT) in women measured usingquantitative PET/CT (funded through NIH - 1RO1DK112260-01). Provided expertise on application of dynamic PET acquisition using 11C-acetate and 18FDG, performing electromyography measurements and performing cold exposure protocol using liquid-conditioned suit. Performing analysis of PET and electromyography measurements. Providing interpretation of primary outcome variables.
  • Research collaboration. United States of America. Providing guidance on the development of shivering activity and burst rate detection algorithm in humans.
  • Research Collaboration. Netherlands. Quantifying the thermogenic and lipolytic response of human and mouse brown adipocytes to beta-adrenergic stimulations.

Présentations

  • (2022). Brown adipose tissue in humans: from therapeutic target to canary in the coal mine. CPH BAT 2022 - The heterogeneity and plasticity of adipose tissue. Copenhagen, Denmark
  • (2022). Examining Futile Cycles as Recruitable Forms of Heat Production – Is it Fruitless?. Recent Advances & Controversies in the Measurement of Energy Metabolism. Quebec City, Canada
  • (2022). Metabolic Responses to Cold Exposure – from survival to therapeutic applications. Integrative Physiology of Exercise 2022. Baltimore, United States of America
  • (2022). The impact of lipolysis on adipose tissue thermogenesis in humans. Zoom Forward 22 - Joint congress of European Association of the Study of Obesity (EASO) and the International Federation for the Surgery of Obesity and meabolic disorders - European Chapter (IFSO-EC). Maastricht, Netherlands
  • (2022). Tissue thermogenesis: from beacon of hope to canary in the coal mine. Centre de Recherche du CHUM seminar. Montreal, Canada
  • (2021). Caractérisation du métabolisme organique in vivo par imagerie TEP. Association francophone pour le savoir (ACFAS). Canada
  • (2021). Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation. National Consortium on BAT research. Germany
  • (2021). Targeting adrenergic receptors to stimulate adipose tissue thermogenesis. 6th German Pharm-Tox Summit of the German Society for Experimental and Clinical Pharmacology and Toxicology. Germany
  • (2020). Beta2 is the primary regulator of human BAT metabolism. ObesityWeek(Virtual). United States of America
  • (2020). Brown Adipose Tissue Thermogenesis: Positron Emission Tomography and Rodent-to-Human Translation. Endocrine Society – New Frontiers in Basic Science: Applying New Technology to Endocrine Research (virtual). Canada
  • (2020). L'imagerie médicale et la caractérisation des désordres métaboliques. Ordre des technologues en imagerie médicale, en radio-oncologie et en électrophysiologie médicale du Québec : Semaine des technologues (virtual). Canada
  • (2020). Left out in the cold: the latest on cold exposure and sympathomimetics for the treatment of type 2 diabetes. Virtual Visiting Scientist Seminar Series for Pennington Biomedical Research Center. United States of America
  • (2020). Targeting recruitable thermogenesis for the treatment of obesity. Novo Nordisk. United States of America
  • (2019). Recruitable thermogenesis for the treatment of metabolic diseases in humans. Boehringer Ingelheim: Energy Expenditure Symposium. Germany
  • Blondin, DP. (2018). Cold-induced thermogenesis: exploring the integrated response to defend against the cold. Dutch ENERGISE symposium. Leiden, Netherlands
  • Lessard, R*, Semeniuk, K, Chahrour, H*, McCormick, JJ, Acosta, F, Blondin DP, Haman, F. (2018). Effects of morphology and body composition on thermogenesis at mean skin temperatures of 33, 31, 29 and 27°C in women and men. 7th International Conference on the Physiology and Pharmacology of Temperature Regulation. Split, Croatia
  • Blondin, DP. (2018). Metabolic Benefits of Cold Exposure. 7th International Conference on the Physiology and Pharmacology of Temperature Regulation (PPTR). Split, Croatia
  • (2018). Physiological implications of brown adipose tissue. International symposium on the role of brown adipose tissue in human health. Granada, Spain
  • (2018). White Adipose Tissue Lipolysis Not Just a Fuel Supply: Re-Visiting the Significant Thermogenic Contribution of the Triglyceride-Fatty Acid Cycle in Humans Exposed to the Cold or Stimulated with a ?3-Adrenergic Receptor Agonist (Mirabegron). Keystone Symposia: Bioenergetics and Metabolic Disease. Keystone, United States of America
  • Acosta F, Martinez-Tellez B, Sanchez-Delgado G, Blondin DP, Haman F, Martinez-Nicolas A, Ruiz JR. (2018). Wrist skin temperature daily rhythm predicts brown adipose tissue 18F-FDG uptake in young adults. 7th International Conference on the Physiology and Pharmacology of Temperature Regulation. Split, Croatia
  • Verdon EJ, Lessard R*, Semeniuk K, Chahrour H*, Blondin DP, Haman F. (2017). Increasing energy expenditure in the cold: effects of small decreases in mean skin temperature. ObesityWeek. Washington, United States of America
  • Lessard R*, Verdon EJ, Semeniuk K, Chahrour H*, Blondin DP, Haman F. (2017). Increasing energy expenditure in the cold: establishing thermal comfort at various mean skin temperatures. ObesityWeek. Washington, United States of America
  • Blondin DP, Frisch F, Turcotte EE, Richard D, Haman F, Carpentier AC. (2017). Investigating cold-induced thermogenesis in humans: recognizing the importance of using an integrative approach. Recent Advances and Controversies in the Measurement of Energy Metabolism. Fribourg, Switzerland
  • (2017). The use of a beta3-adrenergic receptor agonist in humans stimulates BAT glucose disposal, but not thermogenesis. Keystone Symposia: Obesity and Adipose Tissue Biology. Keystone, United States of America
  • Blondin, DP. (2016). Brown adipose tissue in humans: embracing the cold and controversies in targeting BAT for the management of metabolic diseases. EMPhasis on health seminar, MAC-Obesity Research Program. Hamilton, Canada
  • Blondin, DP. (2016). Contributions of white and brown adipose tissues and skeletal muscles to cold-induced metabolic responses. ObesityWeek. New Orleans, United States of America
  • Blondin DP, Frisch F, Phoénix S, Guérin B, Turcotte EE, Richard D, Haman F, Carpentier AC. (2016). Does TAG/FA cycling contribute significantly to cold-induced thermogenesis? Determining the metabolic fate of oversupplied fatty acids during a mild cold exposure in humans. International Academy of Cardiovascular Sciences. Sherbrooke, Canada
  • Blondin DP, Phoénix S, Guérin B, Turcotte EE, Richard D, Haman F, Carpentier AC. (2016). Inhibition of intracellular triglyceride lipolysis significantly impairs BAT oxidative metabolism in humans. Keystone Symposium - Obesity and Adipose Tissue Biology. Canada
  • Blondin DP, Phoénix S, Guérin B, Turcotte EE, Richard D, Haman F, Carpentier AC. (2016). Le role des triglycérides intracellulaire sur le métabolisme de la graisse brune chez des hommes sains exposés au froid. Congrès de la Société Québécoise de lipidologie, de nutrition et de métabolism/Réseau de recherche en santé cardiométabolique, diabète et obésité/COLosSUS. Magog, Canada
  • Raytchev S*, Tingelstad H, Blondin DP, Haman F. (2015). Cold acclimation in humans: Effects of changes in brown fat on the recruitment and shivering pattern of superficial muscles. Experimental Biology. Boston, United States of America
  • Blondin DP, Noll C, Tingelstad H, Labbé SM, Phoenix S, Guérin B, Turcotte EE, Richard D, Haman F, Carpentier AC. (2015). Effets d'une acclimatation au froid sur le métabolism des acides gras alimentaires et la thermogenèse postprandiale chez des hommes sains. Congrès de la Société Québécoise de lipidologie, de nutrition et de métabolism/Réseau de recherche en santé cardiométabolique, diabète et obésité/COLosSUS. Magog, Canada
  • Blondin DP, Noll C, Tingelstad H, Labbé SM, Guérin B, Turcotte EE, Richard D, Haman F, Carpentier AC. (2015). Postprandial energy metabolism of brown adipose tissue in cold-acclimated humans. Keystone Symposia: Beige and Brown Fat: Basic Biology and Novel Therapeutics,. United States of America
  • Daoud A,Taylor T, Taylor AW, Harper ME, Haman F et Aguer C. (2014). Adaptations metaboliques du muscle squelettique de l'homme sain suite à une exposition chronique au froid. Congrès conjoint de la société québécoise de lipidologie, de nutrition et de métabolisme, du réseau de recherche en santé cardiométabolique, diabète et obésité et de COLosSUS. Canada
  • Blondin DP, Labbé SM, Noll C, Kunach M, Phoenix S, Guérin B,Turcotte EE, Haman F, Richard D, Carpentier AC. (2013). Acute cold exposure elicits increases in BAT oxidative metabolism in individuals with Type 2 Diabetes. NIH/NIDDK Workshop: Exploring the role of brown fat in humans. Bethesda, United States of America
  • Blondin DP, Labbé SM, Richard D, Turcotte É, Carpentier AC, Haman F. (2013). Cold acclimation increases the contribution of brown adipose tissue-derived thermogenesis in adult humans. Experimental Biology. Boston, United States of America
  • Aguer C, Blondin DP, Taylor T, Taylor AW, Harper M-E, Haman F. (2013). Cold acclimation in healthy young men results in metabolic modifications in skeletal muscle. The Obesity Society Annual Scientific Meeting. Atlanta, United States of America
  • Blondin DP, Labbé SM, Richard D, Turcotte É, Carpentier AC, Haman F. (2013). Daily cold exposure increases brown adipose tissue-derived thermogenesis in adult humans. Canadian Diabetes Association/Canadian Society of Endocrinology and Metabolism Professional Conference and Annual Meetings. Montreal, Canada
  • Aguer C, Blondin DP, Taylor T, Taylor AW, Harper M-E, Haman F. (2013). Effet d’une exposition aigue et chronique au froid sur le métabolisme du muscle squelettique chez l’homme sain. 5ème Réunion annuelle de la plate-forme COLosSUS. Magog, Canada
  • Blondin DP, Labbé SM, Noll C, Kunach M, Turcotte É, Carpentier AC, Richard D, Haman F. (2013). La contribution thermogénique du tissu adipeux brun augmente suite à un protocole d'acclimatation au froid, chez des hommes sains. 5ème Réunion annuelle de la plate-forme COLosSUS. Magog, Canada
  • (2013). Les processus thermogéniques induite par le froid chez les humains. Undergraduate-level course University of Ottawa, Department of Human Kinetics Course Code: APA 4715 Course name: Les influences externes et l'activité physique. Ottawa, Canada
  • Labbé SM, Blondin DP, Noll C, Kunach M, Turcotte É, Haman F, Carpentier AC, Richard D. (2013). L’exposition aigue au froid n’induit pas l’activation du tissu adipeux brun chez le patient diabétique. 5ème Réunion annuelle de la plate-forme COLosSUS. Magog-Orford, Canada
  • (2012). Lighting the flame within: tissue-specific metabolism of cold exposed humans. Undergraduate-level course University of Ottawa, Department of Biochemistry Course Code: BCH3120 Course Name: General Intermediary Metabolism. Ottawa, Canada
  • (2011). Brown adipose tissue volume correlates inversely to shivering intensity in cold-exposed men. Recent Advances and Controversies in the Measurement of Energy Metabolism. Maastricht, Netherlands
  • (2011). Le recrutement musculaire et le transport intramusculaire du 18Fluorodeoxyglucose (18FDG) et l’acide 18Fluoro-6-thia-heptadécanoïque (18FTHA) lors d’une exposition au froid mesurer par la tomodensitométrie couplée à la tomography par emission de posi. 3ème Réunion annuelle de la plate-forme COLosSUS. Mont Orford, Canada
  • (2011). Muscle recruitment and muscle-specific substrate uptake in cold-exposed humans evaluated by electromyography and positron emission tomography coupled to computed tomography (PET/CT). The Obesity Society, 29th Annual scientific meeting. Orlando, United States of America
  • Labbé, S.M. (2011). Métabolisme du tissu adipeux brun en réponse à une exposition au froid chez des hommes en santé. 3ème Réunion annuelle de la plate-forme COLosSUS. Mont Orford, Canada
  • (2011). Thermogenesis and Fuel Selection during Cold Exposure: Tissue-Specific Metabolism and Cold-Acclimation. Graduate-level course University of Ottawa, Department of Human Kinetics. Course Code: APA6901 Course Title: Selected Topics in Exercise Physiology. Ottawa, Canada
  • (2010). Brown adipose tissue in humans. 11th International Congress on Obesity. Stockholm, Sweden
  • Ouellet, V. (2010). Cold-activated brown adipose tissue metabolism in healthy men. The Obesity Society, 28th Annual scientific meeting. San Diego, United States of America
  • (2010). Cold exposure methodology for investigating brown adipose tissue activation in humans. The Obesity Society, 28th Annual scientific meeting. San Diego, United States of America
  • (2010). Glucose Ingestion and Performance. Graduate-level course University of Ottawa, Department of Human Kinetics Course Code: APA 3114 Course name: Exercise Physiology II. Ottawa, Canada
  • (2010). Investigating the Relationship Between Shivering and Non-Shivering Heat Producing Mechanisms during Mild Cold Exposure. Graduate-level course University of Ottawa, Department of Human Kinetics Course Code: APA 6901 Course name: Selected-topics in Exercise Physiology. Ottawa, Canada
  • (2010). L’ingestion des hydrates de carbone et la performance. Graduate-level course University of Ottawa, Department of Human Kinetics Course Code: APA 3514 Course name: Exercise Physiology II. Ottawa, Canada
  • Haman, F. (2009). Effects of dietary behaviour on exogenous glucose kinetics in 2 Oji-Cree communities of northwestern Ontario. 1st National Obesity Summit. Kananaskis, Canada
  • Haman, F. (2008). Effects of the menstrual cycle on substrate utilization during low-intensity shivering. Canadian Society of Exercise Physiology Annual Scientific Conference. Banff, Canada
  • (2008). Exogenous glucose oxidation during shivering. Graduate-level course University of Ottawa, Department of Human Kinetics. Course Code: APA6901 Course Name: Selected Topics in Exercise Physiology. Ottawa, Canada
  • (2008). Exogenous glucose oxidation during shivering: effects of carbohydrate ingestion timing and type. Canadian Society of Exercise Physiology Annual Scientific Conference. Banff, Canada
  • Dickson, C. (2008). Plasma interleukin-6 concentration increases in parallel to increased fuel utilization during cold exposure. European Congress on Obesity. Switzerland
  • (2008). The Effects of CHO Feeding on Fuel Selection During Low-Intensity Shivering. 13th annual congress of the European College of Sport Science. Estoril, Portugal