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Marie-Josée Boucher

Professeure, Faculté de médecine et des sciences de la santé
FMSS Département de médecine

Présentation

Sujet de recherche

Cell Signaling and Cancer, Enzymes and Proteins, Cancer of the Digestive System, Biological and Biochemical Mechanisms, Cellular Division, Gene Regulation and Expression, Carcinogenesis, Cell

Disciplines de recherche

Cell Biology, Oncology

Mots-clés

Cell signaling, GSK3, Notch, pancreas, cancer, ERK1/2 signaling, proliferation, autophagy, Cell Biology, cell survival

Intérêts de recherche

My research interests aim to delineate the molecular and cellular mechanisms involved in the proliferation, survival and transformation of pancreatic epithelial cells.

Centre de recherche

Centre de recherche du CHUS

Langues parlées et écrites

Anglais, Français

Diplômes

(2007). (Post-doctorate, postdoc). Umea University.

(2004). (Doctorate, Ph.D.). Université de Sherbrooke.

(1999). (Master's Thesis, Master - Masters). Université de Sherbrooke.

(1997). (Bachelor's, Bachelor). Université de Sherbrooke.

Expérience académique

Full Professor. (2017-). Université de Sherbrooke. Canada.

Deputy Director of Research. (2010-). Université de Sherbrooke. Canada.

Affiliated Professor. (2009-). Université de Sherbrooke. Canada.

Associate Professor. (2012-2017). Université de Sherbrooke. Canada.

Assistant Professor. (2007-2012). Université de Sherbrooke. Canada.

Prix et distinctions

  • (2016) Research Scholar-Junior 2 salary award. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2012) Matinée des Chercheurs Boursiers. Club de recherches cliniques du Québec (CRCQ). (Prize / Award).
  • (2012) Research scholar-Junior 1 salary award. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
  • (2011) Outstanding achievement award- 16th world congress on advances in oncology and 14th international symposium on molecular medicine. 16th world congress on advances in oncology and 14th International Symposium on Molecular Medicine. (Prize / Award).
  • Dean's honour list 2014. Université de Sherbrooke. (Honor).

Financement

  • (Under Review). Principal Applicant. Defining the regulation and contribution of TFEB in pancreatic cancer cells. Cancer Research Society (The). Operating grant. 120 000 $. (2020-2022)
  • Grant. (Awarded). Principal Investigator. Role of PIN1 in tissue renewal. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery grant. 145 000 $. (2016-2021)
  • Grant. (Awarded). Principal Investigator. TFEB limits the accumulation of DNA damage to support pancreatic cancer cell growth. Cancer Research Society (The). Operating grant. 120 000 $. (2018-2020)
  • Grant. (Completed). Principal Investigator. Génération d'un modèle orthotopique pour élucider le rôle des facteurs génétiques et du microenvironnement tumoral dans la carcinogenèse pancréatique. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Projet structurant. 75 000 $. (2016-2018)
  • Grant. (Completed). Co-applicant. La culture organoïde: le chainon manquant pour le pronostic et le traitement optimisé des cancers du colon et de la prostate. Centre de Recherche du Centre Hospitalier de l'Université de Sherbrooke Inc. (CRCHUS) (Sherbrooke, QC). Programme de projets structurants. 50 000 $. (2015-2016)

Publications

Articles de revue

  • Marchand B*, Poulin MA*, Boucher MJ. (2020). Gemcitabine induces autophagy through ERK- and TFEB-dependent mechanisms. Cell Death Discovery - -. (Submitted).
  • Blain J*, Bédard J*, Thompson M*, BOISVERT FM, BOUCHER MJ. (2017). C-terminal deletion of NOTCH1 intracellular domain (N1ICD) increases its stability but does not amplify and recapitulate N1ICD-dependentsignalling. Scientific Reports 7 (1), 5034. (Published).
  • Daniel J. Klionsky, (Boucher MJ), et al. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12 (1), 1-222. (Published).
  • Marchand B*, Arsenault D*, Raymond-Fleury A*, BOISVERT FM, BOUCHER MJ. (2015). Glycogen Synthase Kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells. Journal of Biological Chemistry 290 (9), 5592-5605. (Published).
  • Tremblay I* , Paré E* , Arsenault D* , Douziech M* , Boucher MJ. (2013). The MEK/ERK Pathway Promotes NOTCH Signalling in Pancreatic Cancer Cells. PLOS ONE 8 (12), e85502. (Published).
  • Cagnol S, Boucher MJ, Carrier JC, Rivard N. (2012). Activation aberrante de la signalisation KRas/BRaf/MAP kinase dans les cancers pancréatiques et colorectaux. Médecine Sciences Amérique 1 (4), 1-18. (Published).
  • Marchand B*, Tremblay I*, Cagnol S , Boucher MJ. (2012). Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. Carcinogenesis 33 (3), 529-537. (Published).
  • Lemieux E , Boucher MJ , Mongrain S , Boudreau F , Asselin C , Rivard N. (2011). Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation. American journal of physiology. Gastrointestinal and liver physiology 301 (4), G719-730. (Published).
  • Bergeron S , Lemieux E , Durand V , Cagnol S , Carrier JC , Lussier JG , Boucher MJ , Rivard N. (2010). The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. Molecular cancer 9 271. (Published).
  • Mysliwiec P*, Boucher MJ. (2009). Targeting Notch signaling in pancreatic cancer patients-rationale for new therapy. Advances in medical sciences 54 (2), 136-142. (Published).
  • Boucher MJ , Simoneau M* , Edlund H. (2009). The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity. Endocrinology 150 (1), 87-97. (Published).
  • Boucher MJ , Selander L , Carlsson L , Edlund H. (2006). Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms. The Journal of biological chemistry 281 (10), 6395-6403. (Published).
  • Boucher MJ , Laprise P , Rivard N. (2005). Cyclic AMP-dependent protein kinase A negatively modulates adherens junction integrity and differentiation of intestinal epithelial cells. Journal of cellular physiology 202 (1), (Published).
  • Laprise P , Langlois MJ , Boucher MJ , Jobin C , Rivard N. (2004). Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI3K/Akt pathway in differentiating intestinal epithelial cells. Journal of cellular physiology 199 (1),
  • Boucher MJ , Jean D , Vézina A , Rivard N. (2004). Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. American journal of physiology. Gastrointestinal and liver physiology 286 (5), G736-746. (Published).
  • Boucher MJ , Rivard N. (2003). Regulation and role of brush border-associated ERK1/2 in intestinal epithelial cells. Biochemical and biophysical research communications 311 (1),
  • Laprise P , Chailler P , Houde M , Beaulieu JF , Boucher MJ , Rivard N. (2002). Phosphatidylinositol 3-kinase controls human intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAPK activation. The Journal of biological chemistry 277 (10),
  • Charland S , Boucher MJ , Houde M , Rivard N. (2001). Somatostatin inhibits Akt phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells. Endocrinology 142 (1),
  • Boucher MJ , Duchesne C , Lainé J , Morisset J , Rivard N. (2001). cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. Biochemical and biophysical research communications 285 (2),
  • Boucher MJ , Morisset J , Vachon PH , Reed JC , Lainé J , Rivard N. (2000). MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-X(L), and Mcl-1 and promotes survival of human pancreatic cancer cells. Journal of cellular biochemistry 79 (3), 355-369. (Published).
  • Rivard N , Boucher MJ , Asselin C , L'Allemain G. (1999). MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells. The American journal of physiology 277 (4 Pt 1),

Articles de conférence

  • Chatterjee R*, Marchand B*, Bossanyi MF*, Boucher MJ. (2019). DNA-PK sustains autophagy and pancreatic cancer cell growth. 2019 Canadian Digestive Disease Week. (Accepted).
  • Marchand B*, Boucher MJ. (2019). Gemcitabine triggers an autophagy response associated with modulation in the master regulator of autophagy and lysosomal biogenesis TFEB. Pancreas vol. 48, 1486. (Published).
  • Lawson C*, Marchand B*, Arsenault D*, Groleau M*, Tai LH, and Boucher MJ. (2018). TFEB, the master regulator of autophagy and lysosomal biogenesis plays critical role in pancreatic cancer cell growth. Pancreas, 1405. (Published).
  • Bossanyi M*, Groleau M*, Boucher MJ. (2017). Inhibition of DNA-PK interferes with pancreatic cancer cell growth and correlates with inhibition of autophagy. Pancreas, 1392. (Published).
  • Groleau M*, Marchand B*, Boucher MJ. (2017). New potential role for transcription factor EB in DNA repair. Canadian Digestive Disease Week. (Published).
  • Groleau M*, Marchand B*, Boucher MJ. (2016). New potential role for transcription factor EB in DNA repair. Pancreas, 1498. (Published).
  • Groleau M*, Marchand B*, Boucher MJ. (2016). Nouveau rôle potentiel du facteur de transcription EB dans la réparation des dommages à l'ADN. Signalisation Québec 2016. (Published).
  • Blain J*, Boucher MJ. (2016). Régulation Notch-dépendante de la phosphorylation du co-facteur transcription mastermind-like 1 (MAML1). Signalisation Québec 2016. (Published).
  • Thompson M*, Douziech M*, Arsenault D*, BOISVERT FM, BOUCHER MJ. (2015). Proteomic analysis of NOTCH1:establishment of a reliable system to identify new NOTCH1 interacting partners. Canadian Digestive Diseases Week 2015. (Accepted).
  • Pare E*, Arsenault D*, Boucher MJ. (2015). RAS signaling cooperates with the prolyl-isomerase PIN1 to promote the expression of the NOTCH1 intracellular domain NIC1 in pancreatic cancer cells. Canadian Digestive Diseases Week 2015. (Published).
  • Marchand B*, Arsenault D*, Boucher MJ. (2015). The transcription factor TFEB supports pancreatic cancer cell growth. American Pancreatic Association meeting 2015. (Published).
  • Thompson M*, Douziech M*, Arsenault D*, BOISVERT FM, BOUCHER MJ. (2014). Exploitation de la protéomique quantitative pour l'identification de nouveaux partenaires nucléaires de NOTCH1. Journée Phare 2014. (Published).
  • Thompson M*, Arsenault D*, Douziech M*, BOISVERT FM, BOUCHER MJ. (2014). Exploitation de la protéomique quantitative pour l'identification de nouveaux partenaires nucléaires de NOTCH1. Signalisation Québec 2014. (Published).
  • Marchand B*, Raymond-Fleury A*, Boucher MJ. (2014). GSK3 inhibition regulates the master regulator of autophagy and lysosomal biogenesis TFEB in pancreatic cancer cells. Pancreas, 1387. (Published).
  • Paré E*, Boucher MJ. (2014). La prolyl-isomérase PIN1 comme intermédiaire potentiel dans la promotion de l'activité transcriptionnelle de NOTCH1 par la voie MEK/ERK dans les cellules pancréatiques tumorales humaines. Signalisation Québec 2014. (Published).
  • Marchand B*, Raymond-Fleury A*, Boucher MJ. (2014). Regulation of the transcription factor TFEB and the autophagic/lysosomal network by GSK3 in pancreatic cancer cells. Annual Meeting 2014 American Association for Cancer Research. (Published).
  • Marchand B*, Raymond-Fleury A*, Boucher MJ. (2014). Régulation du facteur de transcription EB (TFEB) et de la voie de dégradation autophagique/lysosomale par les GSK3 dans les cellules pancréatiques tumorales. Signalisation Québec 2014. (Published).
  • Thompson M*, Douziech M*, BOISVERT FM, BOUCHER MJ. (2013). Analyse protéomique des partenaires d'interaction de Notch1: identification du complexe médiateur. Club de Recherches Cliniques du Québec. (Published).
  • Marchand B*, Boucher MJ. (2013). Inhibition of GSK3 reduces p70S6K activity and promotes autophagy independently of the JNK-cJun pathway. Proceedings of the 104th Annual Meeting of the American Association for Cancer Research, Abstract nr1674. (Published).
  • Marchand B*, Boucher MJ. (2013). Inhibition of GSK3 reduces p70S6K activity and promotes autophagy in pancreatic cancer cells. Pancreas, 42:1365. (Published).
  • Paré É*, Douziech M*, Boucher MJ. (2013). La modulation de la voie Mek/Erk promeut l'expression de la prolyl-isomérase PIN1 ainsi que des gènes-cibles de la voie Notch dans les cellules pancréatiques tumorales humaines. Club de Recherches Cliniques du Québec. (Published).
  • Blain J*, Robert K*, Douziech M*, Boucher MJ. (2013). Post-translational modifications of the cleaved form of Notch1 (NIC1) determined its mode of degradation; proteosomal vs lysosomal. Canadian Journal of Gastroenterology, 27:A106. (Published).
  • Tremblay I*, Bintz J*, Boucher MJ. (2012). Erk activity promotes Notch-dependent HES1 expression in pancreatic cancer cells. Cancer Research, 72 (8) suppl.1: 1195. (Published).
  • Bintz J*, Boucher MJ. (2012). Impact du niveau d'activation de la voie Notch dans les cellules cancéreuses pancréatiques humaines. Club de Recherches Cliniques du Québec. (Published).
  • Blain J*, Tremblay I*, Boucher MJ. (2012). Importance du domaine PEST de Notch1 avec la coopération de la voie KRas. Club de Recherches Cliniques du Québec. (Published).
  • Marchand B*, Boucher MJ. (2012). Inhibition of GSK3 activity promotes autophagy in pancreatic epithelial cells. Canadian Digestive Diseases Week 2012. (Published).
  • Boucher MJ, Marchand B*, Tremblay I*, Blain J*, Bintz J*, Robert K*, Douziech M*. (2012). Les signaux en aval des glycogène synthase kinase-3 (GSK3) et des récepteurs Notch contribuent au phénotype transformé des cellules pancréatiques tumorales humaines. Club de Recherches Cliniques du Québec. (Published).
  • Robert K*, Tremblay I*, Boucher MJ. (2012). The intracellular domain of Notch1 (NIC1) is hyperphosphorylated following its activation in human pancreatic cancer cells. Pancreas, 41:1398. (Published).
  • Marchand B*, Boucher MJ. (2011). Inhibition of GSK3 activity promotes autophagy in pancreatic epithelial cells. Pancreas, 40:1337. (Published).
  • Tremblay I*, Boucher MJ. (2011). Regulation of Notch signaling by the Mek/Erk pathway. International Journal of Molecular Medicine, 28:S36. (Published).
  • Marchand B*, Boucher MJ. (2011). Treatment with the autophagy inhibitor 3-Methyladenine sensitizes pancreatic cancer cells to GSK3 inhibition-induced apoptosis. Cancer Research, 71 (8) suppl. 1:2874. (Published).
  • Tremblay I*, Boucher MJ. (2010). Erk-dependent phosphorylation of Notch intracellular domain (NIC) correlates with increased NIC-dependent transcription. Cancer Research, 70 (8) suppl. 1:1234. (Published).
  • Boucher MJ, Marchand B*, Tremblay I*. (2010). Inhibition of GSK3 activity promotes apoptosis in pancreatic cancer cells but not in pancreatic immortalized cells. Canadian Journal of Gastroenterology, 24:A13. (Published).
  • Marchand B*, Boucher MJ. (2010). Inhibition of GSK3 activity sensitizes pancreatic cancer cells to TNFalpha-induced apoptosis. Gastroenterology, 138(5):S449. (Published).
  • Tremblay I*, Boucher MJ. (2010). La voie MEK/ERK induit la phosphorylation et favorise l'activité transcriptionnelle du domaine intracellulaire de NOTCH1. Club de Recherches Cliniques du Québec. (Published).
  • Marchand B*, Boucher MJ. (2010). Sensibilisation des cellules pancréatiques tumorales humaines au TNFalpha par l'inhibition des glycogène synthase kinases 3. Club de Recherches Cliniques du Québec. (Published).
  • Marchand B*, Boucher MJ. (2010). The Glycogen Synthase Kinase-3 plays critical roles in the proliferation and survival of human pancreatic cancer cells. International Journal of Molecular Medicine, 26:S40. (Published).
  • Tremblay I*, Boucher MJ. (2010). The Mek/Erk pathway promotes Notch-dependent signaling in human pancreatic cancer cells. Pancreas, 39:1352. (Published).
  • Marchand B*, Tremblay I*, Boucher MJ. (2009). Inhibition of GSK3 activity leads to JNK activation and correlates with pancreatic cancer cell death. Pancreas, 38:1025. (Published).
  • Marchand B*, Boucher MJ. (2009). Interplay between the GSK3 and JNK pathways regulates human pancreatic cancer cell survival. Gastroenterology, 136:A756. (Published).
  • Marchand B*, Tremblay I*, Boucher MJ. (2009). La signalisation croisée entre GSK3 et JNK régule la survie des cellules pancréatiques tumorales humaines. Club de Recherches Cliniques du Québec. (Published).
  • Mysliwiec P*, Boucher MJ. (2009). The Mek/Erk pathway positively modulates the Notch pathway in human pancreatic cancer cells. Pancreas, 38:1030. (Published).
  • Marchand B*, Boucher MJ. (2008). GSK3 regulates proliferation and survival of human pancreatic cancer cells. Gastroenterology, 134:A388. (Published).
  • Marchand B*, Boucher MJ. (2008). Glycogen synthase kinase-3 (GSK3) activity plays crucial role in human pancreatic cancer cell proliferation and survival. Pancreas, 37:483. (Published).
  • Mysliwiec P*, Boucher MJ. (2008). NIC/CSL transcriptional activity is regulated by the Mek/Erk pathway in human pancreatic cancer cells. Pancreas, 37:486. (Published).
  • Mysliwiec P*, Boucher MJ. (2008). Régulation du complexe transcriptionnel NIC/CSL par la voie Mek/Erk. Club de Recherches Cliniques du Québec. (Published).
  • Marchand B*, Boucher MJ. (2008). Rôle des glycogène synthase kinase-3 (GSK3) dans la prolifération et survie des cellules pancréatiques tumorales humaines. Club de Recherche Clinique du Québec. (Published).
  • Lemieux E, Durand V, Boucher MJ, Rivard N. (2007). Constitutive activation of Mek/ERK Mapk pathway induces epithelial-mesenchymal transition in intestinal epithelial crypt cells. Gastroenterology, 132:A538. (Published).
  • Lemieux E, Durand V, Boucher MJ, Rivard N. (2007). L’activation constitutive du sentier MAP Kinase induit une transition épithélium-mésenchyme dans les cellules épithéliales intestinales. Médecine/Sciences, 23:7. (Published).
  • Boucher MJ, Edlund E. (2006). Increased Phosphorylation and Transactivation Properties of IPF1/PDX1 by HIPK2-Dependent Mechanisms. Molecular Biology of the Cell, 17:503. (Published).
  • Durand V, Boucher MJ, Lainé J, Rivard N. (2005). Constitutive activation of MEK/ERK MAPK cascade induces expression and activity of MMP2, MMP9 and serpine2 : roles in intestinal tumorigenesis. Molecular Biology of the Cell, 16:217a. (Published).
  • Boucher MJ, Rivard N. (2004). Dual role of MEK/ERK signalling in senescence and transformation of intestinal epithelial cells. Gastroenterology, 126:A140. (Published).
  • Durand V, Boucher MJ, Rivard N. (2004). Implications des ERK/MAP Kinases dans la transformation cellulaire des cellules épithéliales intestinales. Médecine/Sciences, 20:21. (Published).
  • Boucher MJ, Rivard N. (2003). Constitutive activation of MEK-Erk signalling pathway in human intestinal crypt cells provokes cell cycle arrest associated with accumulation of p21cip. Gastroenterology, 124:A600. (Published).
  • Laprise P, Boucher MJ, Rivard N. (2003). Inhibition of the MEK-ERK pathway by E-cadherin-dependent AKT activity during enterocyte differentiation. Gastroenterology, 124:A275. (Published).
  • Boucher MJ, Jean D, Rivard N. (2003). Modulation of human intestinal epithelial cell proliferation and differentiation by the MAP kinase kinase MEK1. Canadian Journal of Gastroenterology, 17:S72. (Published).
  • Boucher MJ, Rivard N. (2002). Analysis of MEK1 signaling in human intestinal epithelial cell proliferation and differentiation. Gastroenterology, 16:A62. (Published).
  • Boucher MJ, Rivard N. (2002). Regulation of intestinal cell adherens and tight junctions by cAMP/protein kinase A signalling. Canadian Journal of Gastroenterology, 16:A62. (Published).
  • Boucher MJ, Rivard N. (2002). Rôle potentiel de erk1b, une nouvelle kinase activée par mek1, dans la différenciation entérocytaire. Médecine/Sciences, 18. (Published).
  • Boucher MJ, Duchesne C, Rivard N. (2001). L'AMP cyclique inhibe la prolifération et la différenciation des cellules intestinales humaines. Médecine/Sciences, 17:17. (Published).
  • Duchesne C, Boucher MJ, Rivard N. (2001). Mécanismes d'action du TGF? dans l'inhibition de la prolifération des cellules épithéliales de la crypte intestinale. Médecine/Sciences, 17:40. (Published).
  • Laprise P, Houde M, Chailler P, Beaulieu JF, Boucher MJ, Rivard N. (2001). Phosphatidyl inositol 3-kinase controls intestinal epithelial cell differentiation by promoting adherens junction assembly and p38 MAP kinase activation. Molecular Biology of the Cell, 12:150A-151A. (Published).
  • Boucher Mj, Duchesne C, Rivard N. (2001). cAMP inhibits cell cycle progression and negatively modulates human intestinal cell differentiation. Gastroenterology, 120:A498. (Published).
  • Boucher MJ, Vézina A, Rivard N. (2000). Differential expression and regulation of p42 and p44 MAP kinases isoforms in the human intestinal jejunum. Gastroenterology, 118: A546. (Published).
  • Boucher MJ, Vézina A, Rivard N. (2000). Differential expression and regulation of p42 and p44 MAP kinases isoforms in the human intestinal jejunum. Canadian Journal of Gastroentorology, 14: 42A. (Published).
  • Boucher MJ, Rivard N. (2000). L'AMP cyclique inhibe la prolifération mais médie un signal de survie dans les cellules pancréatiques tumorales humaines. Médecine/Sciences, 16:43. (Published).
  • Boucher MJ, Morisset J, Vachon PH, Rivard N. (2000). The p42/p44 MAPK signaling pathway regulates survival of human pancreatic cancer cells. Canadian Journal of Gastroenterology, 14:17A. (Published).
  • Boucher MJ, Vachon PH, Morisset J, Rivard N. (1999). Survival-promoting effect of p42/p44 MAP kinases in human pancreatic tumoral cell lines. Gastroenterology, 116:A492. (Published).
  • Yu SJ, Boudreau F, Désilets A, Boucher MJ, Rivard N, Asselin A. (1999). TGF?-induced attenuation of haptoglobin expression in intestinal epithelial cells involves the MAP kinase cascade pathway. Gastroenterology, 116:A855. (Published).
  • Boucher MJ, Aliaga JC, Morisset J, Rivard, N. (1998). Mécanismes d’action moléculaires du TGF? et de l’AMPc dans l’inhibition de la prolifération des cellules intestinales. Médecine/Sciences, 14:49. (Published).
  • Boucher MJ, Brodeur J, Morisset J., Rivard N. (1998). TGF? and cAMP inhibit proliferation of PANC-1, a human pancreatic cell line, by different molecular mechanisms. Pancreas, 16:427. (Published).
  • Boucher C, Boucher MJ, Calvo EV, Morisset J. (1997). Pancreatic injurin release following acute pancreatitis in the rat. Digestion, United Kingdom, 1-11. (Published).
  • Marchand B*, Boucher MJ. DNA damage agents promote TFEB function and induce a pro-survival autophagic signal. Annual meeting of the American Association for Cancer Research. (Accepted).

Autres contributions

Cours enseignés

  • Médiateurs chimiques. PHR702. (2013-03-19).
  • Différenciation et métabolisme. BCL505. (2012-03-20).
  • Biochimie des protéines-pathologies associées. BCH711. (2012-02-28).
  • Biologie Médicale I. (2010-09-03).
  • Signalisation Intracellulaire. BCL740. (2008-05-15).

Gestion d'évènements

  • Organizer. (2016) Signalisation Québec 2016. (Conference).
  • Reviewer. (2014) 2014 DDW (Digestive Disease Week). (Conference).
  • Session Chair. (2013) 10th Symposium on the Physiology and Diseases of the Digestive Tract. (Conference).
  • Organizer of the social activities. (2013) 10th Symposium on the Physiology and Diseases of the Digestive Tract. (Conference).
  • Reviewer. (2013) 2013 DDW (Digestive Disease Week). (Conference).
  • Reviewer. (2012) 2012 DDW (Digestive Disease Week). (Conference).
  • Session Chair. (2011) 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine. (Conference).
  • Co-Organizer. (2011) 1st International Symposium on the physiology and diseases of the digestive tract (PDGI 2011). (Conference).
  • Responsible of the Cell biology category. (2011) 79th edition of ACFAS (association Francophone pour le Savoir). (Conference).
  • Reviewer. (2011) 2011 DDW (Digestive Disease Week). (Conference).
  • Session Chair. (2010) 15th World Congress on Advances in Oncology, 13th International Symposium on Molecular Medicine. (Conference).
  • Session Chair. (2009) CRCQ 2009 (Club de Recherches Cliniques du Québec). (Conference).

Présentations

  • Boucher MJ. (2018). Le facteur de transcription TFEB, un régulateur important dans les cellules pancréatiques tumorales humaines. Signalisation Québec 2018. Bécancour, Canada
  • Boucher MJ. (2015). Regulation of the master regulator of autophagy and lysosomal biogenesis TFEB by GSK3. 20th World Congress on Advances in Oncology and 18th International Symposium on Molecular Medicine. Athens, Greece
  • Boucher MJ. (2014). GSK3 inhibition triggers both apoptotic and autophagic signals in pancreatic cancer cells. 4th World Congress on Cancer Science and Therapy. Chicago, United States
  • (2014). Les glycogène synthases kinases 3 (GSK3): des rhéostats de la survie cellulaire. Signalisation Québec 2014. Bécancour, Canada
  • Boucher MJ. (2013). La voie RAS/RAF/MEK/ERK promeut la signalisation NOTCH dans les cellules pancréatiques tumorales humaines. Colloque Université Laval-Université de Rennes 1 (France) en oncologie, Association francophone pour le savoir (acfas). Québec, Canada
  • (2012). Les signaux en aval des GSK3 et des récepteurs Notch contribuent au phénotype transformé des cellules pancréatiques tumorales humaines. Club de Recherches Cliniques du Québec (CRCQ); Matinée des chercheurs-boursiers. Orford, Canada
  • Boucher MJ. (2011). Regulation of Notch signaling by the Erk pathway. 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine. Rhodes Island, Greece
  • (2010). Nouvelles perspectives dans le traitement du cancer pancréatique. Conférence magistrale (Grand Round), Department of Medicine, Université de Sherbrooke. Sherbrooke, Canada
  • (2010). Nouvelles perspectives dans le traitement du cancer pancréatique. Conférence de la recherche, Centre de Recherche Clinique Étienne LeBel. Sherbrooke, Canada
  • (2010). Rôles des GSK3 dans les cellules pancréatiques tumorales humaines. Signalisation Québec. Orford, Canada
  • Boucher MJ. (2010). The GSK3 plays critical roles in the proliferation and survival of human pancreatic cancer cells. 15th world congress on Advances in Oncology and 13th International Symposium on Molecular Medicine. Loutraki, Greece
  • (2008). Contribution des glycogène synthase kinases-3 (GSK3) dans la prolifération et la survie des cellules épithéliales pancréatiques tumorales humaines. 7th symposium on Digestive physiopathology. Orford, Canada