François Boudreau

Prix et distinctions

• (2023) Visiting Research Professorship Award. Canadian Association of Gastroenterology. (Prize / Award).
• (2013) Prix RECMUS Faculté de Médecine et des Sciences de la Santé de l'Université de Sherbrooke (Best Student Mentor Award). Université de Sherbrooke. (Prize / Award).
• (2013) Chercheur Boursier Senior Research Award. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
• (2012) Prix Pierre-et-Danielle-Bourgaux de la Faculté de Médecine et des Sciences de la Santé de l'Université de Sherbrooke (Best Young Researcher Award of the year). Université de Sherbrooke. (Prize / Award).
• Associate Editor for the BMC Molecular Biology journal. BMC Molecular Biology. (Distinction).
• Editorial Board Member for World Journal of Gastrointestinal Pathophysiology. World Journal of Gastrointestinal Pathophysiology. (Distinction).
• Editorial Board member for Scientific Reports. Scientific Reports. (Distinction).
• Guest Professor. Nanjing Medical University. (Distinction).
• Prix Diego-Bellabarba Faculté de médecine et des sciences de la santé. Université de Sherbrooke. (Prize / Award).

Financement

• (Awarded). Principal Applicant. Investigating a Novel HNF4A-Gasdermin D Epithelial Regulatory Node in Gut Inflammation. Canadian Institutes of Health Research (CIHR). Project. 1 109 250 $. (2022-2027)
• (Awarded). Co-applicant. Identifying and functionally validating IBD genes and variants impacting intestinal epithelial barrier integrity (0$). Canadian Institutes of Health Research (CIHR). Project. 1 000 000 $. (2021-2026)
• Grant. (Awarded). Principal Applicant. Defining the molecular mechanisms driving intestinal epithelial cell specification. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery. 450 000 $. (2017-2026)
• Grant. (Awarded). Co-applicant. In vivo roles of autophagy in gut homeostasis and impact on IBD (0$). Canadian Institutes of Health Research (CIHR). Project. 895 050 $. (2020-2025)
• Grant. (Awarded). Co-applicant. Biomolecular and biomechanical impact of Foxl1+ mesenchymal telocytes on epithelial cell behaviour in gut-related diseases. Canadian Institutes of Health Research (CIHR). Project scheme. 1 105 426 $. (2019-2024)
• Grant. (Awarded). Principal Applicant. The Nuclear Receptor HNF4A as a Regulator of WNT Ligands: Biological Impact of this Novel Interaction in Gut Diseases. Canadian Institutes of Health Research (CIHR). Project Scheme. 1 081 000 $. (2018-2023)
• (Completed). Principal Applicant. Repurposing drugs to target HNF4A during IBD. Crohn's & Colitis Foundation of Canada (CCFC). Innovation grant. 50 000 $. (2020-2021)
• (Completed). Principal Applicant. Chronic Inflammation, Immunity and Cancer 2019. Canadian Institutes of Health Research (CIHR). Planning and Dissemination Grant. 15 000 $. (2019-2019)
• Grant. (Completed). Co-applicant. Functional contribution of the bone morphogenetic proteins signalling pathway in the reprogramming of gastrointestinal reactive mesenchyme. (2014-2019)
• Grant. (Completed). Principal Applicant. Role of the nuclear receptor corepressor-1 in blocking inflammatory gene expression. (2013-2018)
• Grant. (Completed). Co-applicant. The Sherbrooke Personalized Colorectal Cancer Avatar Models Initiative (COLOR project) :A Feasibility Study of Treatment Guided by the Combination of a Living Organoids Biobank and Personalized Avatars in Patients with Advanced Colorectal Cancer. Merck Sharp & Dohme. Operation program. 250 000 $. (2016-2018)
• Grant. (Completed). Co-applicant. In vivo studies of autophagy : from the model organism to human organoids. Canada Foundation for Innovation (CFI). John R. Evans Leaders Fund. 932 400 $. (2017-2018)
• Grant. (Completed). Principal Investigator. Regulatory roles of hepatocyte nuclear factor 1 and 4 in gastrointestinal metabolic disorders. (2013-2018)
• Grant. (Completed). Co-applicant. Discovery of prognostic biomarkers for the implementation of personalized treatments for patients with colorectal cancer. Merck Sharp & Dohme Research Laboratory. Merck Sharp & Dohme Corporation Funds. 250 000 $. (2015-2017)
• Grant. (Completed). Principal Applicant. Defining the molecular mechanisms driving intestinal epithelial cell specification. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery. 31 000 $. (2016-2017)
• Grant. (Completed). Principal Applicant. The organoid culture: the missing link for the prognostic and personalized treatment of colon and prostate cancer. Centre de recherche CHUS. Projets structurants. 50 000 $. (2015-2016)
• Grant. (Completed). Principal Investigator. Molecular Mechanisms of Intestinal Gene Transcription. (2008-2016)
• Grant. (Completed). Co-applicant. High-throughput protein immunolocalization analysis through virtual fluorescence imaging, Equipment. (2015)
• Grant. (Completed). Co-applicant. Myofibroblast-associated PTEN signalling in intestinal tumor initiation and progression. (2012-2014)
• Grant. (Completed). Principal Investigator. Role of HNF4alpha targets during intestinal epithelium regeneration. (2012-2014)
• Grant. (Completed). Principal Investigator. Mécanismes moléculaires impliqués dans la transcription de gènes intestin-spécifiques au cours du développement normal et pathologique de l'intestin. (2010-2013)
• Grant. (Completed). Principal Investigator. Targeting Transcriptional Repression to Modulate Intestinal Inflammation. (2010-2013)
• Grant. (Completed). Co-investigator. CIHR Team on Digestive Epithelium. (2007-2012)
• Grant. (Completed). Principal Investigator. Functional role of specific transcriptional regulators during intestinal epithelial development and maintenance. (2008-2011)

Publications

Articles de revue

• Jones C, Avino M, Boudreau F. (2022). Hepatocyte Nuclear Factor 4A Acts as a Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate. Cell Mol Gastroenterol Hepatol (IF 9.2) XX (XX), XX. (Revision Requested).
• Girard R, Tremblay S, Noll C, St-Jean S, Jones C, Gelinas Y, Maloum-Rami F, Perreault N, Laplante M, Carpentier AC, Boudreau F. (2022). The transcription factor Hepatocyte Nuclear Factor 4A acts in the intestine to promote white adipose tissue energy storage. Nature Communications (IF 14.9) 13 (1), 224. (Published).
• Vilcy Reyes Nicolas, Joannie M Allaire, Alain B Alfonso, Dianne Pupo Gomez, Veronique Pomerleau, Veronique Giroux, François Boudreau, Nathalie Perreault. (2021). Altered mucus barrier integrity and increased susceptibility to colitis in mice upon loss of telocyte bone morphogenetic protein signaling. Cells (IF 6.6) 10 (11), 2954. (Published).
• Sohail, Muhammad; Shkreta, Lulzim; Toutant, Johanne; Rabea, Safwat; Babeu, Jean-Philippe; Boudreau, Francois; Placet, Morgane; Gendron, Fernand-Pierre; Geha, Sameh; Tyers, Mike; Grierson, David; Chabot, Benoit. (2021). A novel class of CLK kinases inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. NAR Cancer 3 (2), 1-22. (Published).
• Gonneaud A, Turgeon N, Boisvert F-M, Boudreau F, Asselin C. (2021). JAK-STAT pathway inhibition partially restores intestinal homeostasis in Hdac1- and Hdac2-intestinal epithelial cell-deficient mice. Cells (IF 6.6) 10 (2), 224. (Published).
• St-Jean, S., De Castro, A.C., Lecours, M., Jones, C., Rivard, N., Rodier, F., Perreault, N., Boudreau, F. (2021). NCOR1 Sustains Colorectal Cancer Cell Growth and Protects from Cellular Senescence. Cancers (IF 6.6) 13 (17), 4414. (Published).
• Pupo Gomez D. and Boudreau F. (2021). Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties during Intestinal Diseases. Front. Cell Dev. Biol. (IF 6.7) 9 (article 7), 1-8. (Published).
• Montenegro-Miranda PS, van der Meer JHM, *Jones C, Meisner S, Vermeulen JLM, Koster J, Wildenberg ME, Heijmans J, Boudreau F, Ribero A, van den Brink GR, Muncan V. (2020). A novel organoid model of damage and repair identifies HNF4A as a critical regulator of intestinal epithelial regeneration. Cell Mol Gastroenterol Hepatol (IF 9.2) 10 (2), 209-223. (Published).
• *Lambert E, *Babeu J-P, Simoneau J, Raish J, Lavergne L, Levesque D, Jolibois E, Avino M, Scott M, Boudreau F* and Boisvert F-M*; * co-senior authors. (2020). Human Hepatocyte Nuclear Factor alpha encodes isoforms with distinct transcriptional functions. Mol Cell Proteomics (IF 5.9) 19 (5), 808-827. (Published).
• *Gonneaud A., Turgeon N., *Jones C., Couture C., Levesque D., Boisvert F.M., Boudreau F., Asselin C. (2019). Hdac1 and Hdac2 independently regulate common and specific intrinsic responses in murine enteroids. Scientific Reports (IF 4.4) 9 (1), 5363. (Published).
• *Girard R., *Darsigny M., *Jones C., Rami-Maloum F., Gélinas Y., Carpentier A.C., Laplante M., Perreault N., Boudreau F. (2019). Hepatocyte nuclear factor 4a is a novel regulator of glucose-dependent insulinotropic polypeptide. Scientific Reports (IF 4.4) 9 (4200), 1-11. (Published).
• Langlois M.J., Servant R., Reyes-Nicolas V., *Jones C., Roy SAB., Paquet M., Carrier J., Rivard N., Boudreau F. and Perreault N. (2019). Loss of PTEN signaling in Foxl1+ mesenchymal telocytes initiates spontaneous colonic neoplasia in mice. Cell Mol Gastroenterol Hepatol (IF 9.2) 8 (3), 530-33. (Published).
• *Babeu J-P, *Wilson S, Lambert E, Lévesque D, Boisvert FM, Boudreau F. (2019). Quantitative proteomics identifies DNA repair as a novel biological function for Hepatocyte Nuclear Factor 4a in colorectal cancer cells. Cancers (IF 6.6) 11 (5), 626. (Published).
• *Babeu J-P, *Jones C, Geha S, Carrier JC, Boudreau F. (2018). P1 promoter-driven HNF4a isoforms are specifically repressed by ?-catenin signaling in colorectal cancer cells. J. Cell. Sci. (IF 5.3) 131 (13), jcs214734. (Published).
• Placet M, Arguin G, Molle C, *Babeu J-P, *Jones C, Robaye B, Geha S, Boudreau F, Gendron F-P. (2018). The G protein-coupled P2Y6 receptor promotes colorectal cancer tumorigenesis by inhibiting apoptosis. BBA Molecular Basis of Disease (IF 5.2) 1864 (5), 1539-1551. (Published).
• Cho C-H, Kanellos I, Helena J, Hekmatdoost, Boudreau F. (2017). Current trends in digestive disorders. Arch Dig Disord 1 (1), 1-2. (Published).
• Leblanc C, Langlois M-J, Coulombe G, Vaillancourt-Lavigueur V, *Jones C, Boudreau F, Rivard N. (2017). Epithelial Src homology region 2 domain-containing phosphatase-1 restrains intestinal growth, secretorycell differentiation and tumorigenesis. Faseb J (IF 5.2) 31 (8), 3512-3526. (Published).
• St-Jean M, Boudreau F, Carpentier A-C Hivert M-F. (2017). HNF1A defect influences post-prandial lipid regulation. PLOS One (IF 3.2) 12 (5), e0177110. (Published).
• *Gonneaud A, Asselin C, Boudreau F, Boisvert F-M. (2017). Phenotypic Analysis of Organoids by Proteomics. Proteomics (IF 4.0) 17 (20), 1-6. (Published).
• *Latreille R., Servant R, *Jones C, *Darsigny M, Marcoux S, Perreault N, Boudreau F. (2017). Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 signalling complex. BBA Molecular Cell Research (IF 4.7) 1864 (12), 2347-2355. (Published).
• *Gonneaud A, *Jones C, Turgeon N, Lévesque D, Asselin C, Boudreau F, Boisvert F-M. (2016). A SILAC-Based Method for Quantitative Proteomic Analysis of Intestinal Organoids. Scientific Reports (IF 4.4) 6 38195. (Published).
• Allaire JM, Roy SA, Ouellet C, Lemieux E, *Jones C, Paquet M, Boudreau F, Perreault, N. (2016). Bmp signalling in colonic mesenchyme regulates stroll microenvironment and protects from polyposis initiation. Int J Cancer (IF 7.4) 138 (11), 2700-12. (Published).
• Bian B, *Mongrain S, Cagnol S, Langlois M-J, Boulanger J, Bernatchez G, Carrier J, Boudreau F, Rivard N. (2016). Cathepsin B promotes colorectal tumorigenesis, cell invasion and metastasis. Molecular Carcinogenesis (IF 4.8) 55 (5), 671-87. (In Press).
• *Lepage D, *Bélanger E, Tremblay S, *Jones C, Allaire J, *Bruneau J, Asselin C, Perreault N, Menendez A, Gendron F-P, Boudreau F. (2016). Gata4 is critical to maintain functional intestinal epithelial barrier function and jejunum mucosal integrity following epithelial injury. Scientific Reports (IF 4.4) 6 36776. (Published).
• Roy S, Allaire J, Ouellet C, Maloum-Rami F, Pomerleau V, Lemieux E, *Babeu J-P, Rousseau J, Paquet M, Garde-Granger P, Boudreau F, Perreault N. (2016). Loss of mesenchymal bone morphogenetic protein signaling leads to development of reactive stroma and initiation of the gastric neoplastic cascade. Scientific Reports (IF 4.4) 6 32759. (Published).
• Coulombe G, Langlois A, De Palma G, Langlois M-J, McCarville C, Gagné-Sansfaçon J, Perreault N, Feng G-S, Bercik P, Boudreau F, Verdu E-F, Rivard N. (2016). SHP-2 phosphatase prevents colonic inflammation in controlling secretory cell differentiation and maintaining host-microbiota homeostasis. J. Cell Physiol. (IF 6.4) 231 (11), 2529-40. (Published).
• Mathieu A-A, Ohl-Séguy E, Dubois M-L, Jean D, *Jones C, Boudreau F, Boisvert F-M. (2016). Subcellular proteomics analysis of different stages of colorectal cancer cell lines. Proteomics (IF 4.0) 16 (23), 3009-3018. (Published).
• Shen J, Li WX, Xiao ZG, Zhang L, Li MX, Li LF, Hu W, Lu L, Boudreau F, Cho CH. (2016). The co-regulatory role of 5-lipoxygenase and cyclooxygenase-2 in the carcinogenesis and their promotion by cigarette smoking in colons. Curr Med Chem (IF 4.2) 23 (11), 1131-8. (Published).
• Bisson F, Paquet C, Bourget J-M, Zaniolo K, Rochette P-J, Landreville S, Damour O, Boudreau F, Auger F-A, Guérin S-L, Germain L. (2015). Contribution of Sp1 to telomerase expression and activity in skin keratinocytes cultured with a feeder layer. J Cell Physiol (IF 6.4) 230 (2), 308-17. (Published).
• *Brial F, *Lussier CR, Belleville K, Sarret P, Boudreau F. (2015). Ghrelin inhibition restores glucose homeostasis in hepatocyte nuclear factor-1alpha (MODY3) deficient mice. Diabetes (IF 9.5) 64 (9), 3314-20. (Published).
• Marcil V, Devendra A, Seidman E, Boudreau F, Gendron F-P, Menard D, Beaulieu J-F, Sinnett D, Schohraya S, Levy E. (2015). Hepatocyte nuclear factor 4 alpha polymorphisms and the metabolic syndrome in french-canadian youth. PLoS One (IF 3.2) 10 (2), e0117238. (Published).
• *Lepage D, *Bruneau J, *Brouillard G, *Jones C, *Lussier C-R, Rémillard A, *Lemieux É, Asselin C, Boudreau F. (2015). Identification of GATA-4 as a novel transcriptional regulatory component of regenerating islet-derived family members. Biochim Biophys Acta GRM (IF 4.5) 1849 (12), 1411-22. (Published).
• *Gonneaud A, Turgeon N, Boisvert F-M, Boudreau F, Asselin C. (2015). Loss of Histone Deacetylase Hdac1 Disrupts Metabolic Processes in Intestinal Epithelial Cells. FEBS Letters (IF 4.1) 589 (19), 2776-83. (Published).
• *Babeu JP , Boudreau F. (2014). Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks. World journal of gastroenterology : WJG 20 (1), 22-30. (Published).
• Gagne-Sansfaçon J, Allaire J,*Jones C, Boudreau F, Perreault N. (2014). Loss of sonic hedgehog leads to alteration in intestinal secretory cells maturation and autophagy. PLoS One 9 (6), e98751. (Published).
• Turgeon N , Moore Gagné J , Blais M , Gendron FP , Boudreau F , Asselin C. (2014). The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis. American journal of physiology. Gastrointestinal and liver physiology 306 (7), G594-605. (Published).
• Coulombe G , Leblanc C , Cagnol S , Maloum F , Lemieux E , Perreault N , Feng GS , Boudreau F , Rivard N. (2013). Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Molecular and cellular biology 33 (11), 2275-84. (Published).
• Turgeon N , Blais M , Gagné JM , Tardif V , Boudreau F , Perreault N , Asselin C. (2013). HDAC1 and HDAC2 Restrain the Intestinal Inflammatory Response by Regulating Intestinal Epithelial Cell Differentiation. PloS One 8 (9), e73785. (Published).
• *Jones C , *St-Jean S , *Fréchette I , *Bergeron D , Rivard N , Boudreau F. (2013). Identification of a novel promyelocytic leukemia zinc-finger isoform required for colorectal cancer cell growth and survival. International journal of cancer 133 (1), 58-66. (Published).
• Molloy-Simard V , St-Laurent JF , Vigneault F , Gaudreault M , Dargis N , Guérin MC , Leclerc S , Morcos M , Black D , Molgat Y , Bergeron D , de Launoit Y , Boudreau F , Desnoyers S , Guérin S. (2012). Altered expression of the poly(ADP-ribosyl)ation enzymes in uveal melanoma and regulation of PARG gene expression by the transcription factor ERM. Investigative ophthalmology & visual science 53 (10), 6219-31. (Published).
• Marcil V , Sinnett D , Seidman E , Boudreau F , Gendron FP , Beaulieu JF , Menard D , Lambert M , Bitton A , Sanchez R , Amre D , Levy E. (2012). Association between genetic variants in the HNF4A gene and childhood-onset Crohn's disease. Genes and immunity 13 (7), 556-65. (Published).
• Roy SAB, Langlois MJ , Carrier JC , Boudreau F , Rivard N , Perreault N. (2012). Dual regulatory role for phosphatase and tensin homolog in specification of intestinal endocrine cell subtypes. World journal of gastroenterology : WJG 18 (14), 1579-89. (Published).
• Couture F , D'Anjou F , Desjardins R , Boudreau F , Day R. (2012). Role of proprotein convertases in prostate cancer progression. Neoplasia (New York, N.Y.) 14 (11), 1032-42. (Published).
• Lemieux E , Boucher MJ , *Mongrain S , Boudreau F , Asselin C , Rivard N. (2011). Constitutive activation of the MEK/ERK pathway inhibits intestinal epithelial cell differentiation. American journal of physiology. Gastrointestinal and liver physiology 301 (4), G719-30. (Published).
• Allaire J,* Darsigny M , Marcoux SS , Roy SA , Schmouth JF , Umans L , Zwijsen A , Boudreau F , Perreault N. (2011). Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis. American journal of physiology. Gastrointestinal and liver physiology 300 (4), G586-97. (Published).
• Benoit YD , Paré F , Francoeur C , Jean D , Tremblay E , Boudreau F , Escaffit F , Beaulieu JF. (2010). Cooperation between HNF-1alpha, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line. American journal of physiology. Gastrointestinal and liver physiology 298 (4), G504-17. (Published).
• *Darsigny M ,* St-Jean S , Boudreau F. (2010). Cux1 transcription factor is induced in inflammatory bowel disease and protects against experimental colitis. Inflammatory bowel diseases 16 (10), 1739-50. (Published).
• *Darsigny M , *Babeu JP , Seidman EG , Gendron FP , Levy E , Carrier J , Perreault N , Boudreau F. (2010). Hepatocyte nuclear factor-4alpha promotes gut neoplasia in mice and protects against the production of reactive oxygen species. Cancer research 70 (22), 9423-33. (Published).
• *Lussier CR, *Brial F , Roy SA , Langlois MJ , Verdu EF , Rivard N , Perreault N , Boudreau F. (2010). Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PloS one 5 (8), e12378. (Published).
• Marcil V, Seidman E, Sinnett D, Boudreau F, Gendron FP, Beaulieu JF, Menard D, Precourt LP, Amre D, Levy E. (2010). Modification in oxidative stress, inflammation, and lipoprotein assemblyin response to hepatocyte nuclear factor 4alpha knockdown in intestinalepithelial cells. J. Biol. Chem. 285 (52), 40448-60. (Published).
• Marcil V , Seidman E , Sinnett D , Boudreau F , Gendron FP , Beaulieu JF , Ménard D , Precourt LP , Amre D , Levy E. (2010). Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells. The Journal of biological chemistry 285 (52), 40448-60. (Published).
• Haha R, Seidman E, Mailhot G, Boudreau F, Gendron FP, Beaulieu JF, Menard D, Delvin E, Amre D, Levy E. (2010). Oxidative stress and mitochondrial functions in the intestinal Caco-2/15cell line. PLoS one 5 (7), e11817. (Published).
• Langlois MJ, Bergeron S , Bernatchez G , Boudreau F , Saucier C , Perreault N , Carrier JC , Rivard N. (2010). The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression. PloS one 5 (12), e15742. (Published).
• *Frechette I , *Darsigny M , *Brochu-Gaudreau K , *Jones C , Boudreau F. (2010). The Promyelocytic Leukemia Zinc Finger (PLZF?) gene is a novel transcriptional target of the CCAAT-Displacement-protein (CUX1) repressor. The FEBS journal 277 (20), 4241-53. (Published).
• Langlois MJ, Roy SA, Auclair BA, Jones C, Boudreau F, Carrier JC, Rivard N, Perreault N. (2009). Epithelial phosphatase and tensin homolog regulates intestinalarchitecture and secretory cell commitment and acts as a modifier gene in neoplasia. FASEB J 23 (6), 1835-44. (Published).
• Babeu JP, Darsigny M, Lussier CR, Boudreau F. (2009). Hepatocyte-nuclear-factor4alpha contributes to an intestinal epithelial phenotype and plays a partialrole in mouse intestinal epithelium differentiation. Am. J. Physiol. Gastrointest Liver Physiol. 297 (1), G124-34. (Published).
• Darsigny, M., Babeu, J.P., Dupuis, A.A., Furth E.E., Seidman, E.G., Lévy, E., Verdu, E.F., Gendron, F.P., Boudreau F. (2009). Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel diseases in mice. PLoS One 4 (10), e7609. (Published).
• Doyon G., St-Jean, S., Darsigny, M., Asselin, C., Boudreau, F. (2009). Nuclear receptor co-repressor is required to maintain proliferation of normal intestinal epithelial cells in culture and down-modulates the expression of pigment epithelium-derived factor. J Biol Chem 284 (37), 25220-9. (Published).
• Lussier CR, Babeu JP, Auclair B, Perreault N, Boudreau F. (2008). Hepatocyte-nuclear-factor-4alpha promotes differentiation of intestinal epithelial cells in a co-culture system. Am. J. Physiol. Gastrointest Liver Physiol 294 (2), G418-28. (Published).
• Montois A, Seidman E, Boudreau F, Beaulieu JF, Menard D, Elchebly M, Mailhot G, Sane AT, Lambert M, Delvin E, Levy E. (2008). Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake. J. Lip. Res. 49 (5), 961-72. (Published).
• Boudreau F, Rivard N, Gendron FP, Beaulieu JF. (2007). CDX2: a transcription factor with multiple tasksfor epithelial cells of the digestive tract. Med Sci 23 (1), 7-8. (Published).
• Boudreau, F., Lussier, C.R., Mongrain, S., Darsigny, M., Drouin, J.L., Doyon, G., Suh, E.R., Beaulieu, J.F., Rivard, N., Perreault, N. (2007). Loss of cathepsin L activity promotes claudin-1 over expression and intestinal neoplasisa. FASEB J 21 (14), 3853-65. (Published).
• Escafit F, Pare F, Gauthier R, Rivard N, Boudreau F, Beaulieu JF. (2006). Cdx2 modulates proliferation in normal human intestinal epithelial crypt cells. Biochem Biophys Res Commun 342 (1), 66-72. (Published).
• Boulanger J, Vezina A, Mongrain S, Boudreau F, Perreault N, Auclair BA, Laine J, Asselin C, Rivard N. (2005). Cdk2-dependentphosphorylation of homeobox transcription factor CDX2 regulates its nucleartranslocation and proteasome-mediated degradation in human intestinal epithelialcells. J. Biol. Chem. 280 (18), 18095-107. (Published).
• Escafitt F, Boudreau F, Beaulieu JF. (2005). Differential expression of claudin-2 along the human intestine: implication of GATA-4 in the maintenance of claudin-2 indifferentiating cells. J. Cell Physiol. 203 (1), 15-26. (Published).
• van Wering HM, Bosse T, Musters A, de Jong E, de Jong N, Hogen Esch CH, Boudreau F, Swain GP, Dowling LN, Montgomery RK, Grand RJ, Krasinski SD. (2004). Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. Am. J. Physiol. Gastrointest. Liver Physiol. 287 (4), G899-909. (Published).
• Boudreau F, Rings EHHM, Swain G, Sinclair AM, Suh ER, Silberg DG, Scheuermann RH, Traber PG. (2002). A novel colonic repressor element regulates intestinal gene expressionby interacting with Cux/CDP. Mol. Cell Biol. 22 5467-78. (Published).
• Boudreau F, Rings EHHM, van Wering HM, Kim RK, Swain G, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG. (2002). Hepatocyte-nuclear-factor-1a,GATA-4 and caudal-related homeodomain protein Cdx2 interact functionally tomodulate intestinal gene expression: Implication for the developmentalregulation of the sucrase-isomaltase gene. J. Biol. Chem. 277 (35), 31909-917. (Published).
• van Wering HM, Huibregtse IL, van der Zwan SM, de Bie MS, Dowling LN, Boudreau F, Rings EHHM, Grand RJ, Krasinski SD. (2002). Physical interaction between GATA-5 and Hepatocyte Nuclear Factor-1a results in synergistic activation of the human lactase-phlorizinhydrolase promoter. J. Biol. Chem. 277 (31), 27659-667. (Published).
• Rings EHHM, Boudreau F, Taylor JK, Moffett J, Suh ER, Traber PG. (2001). Phosphorylation of the serine 60 residue within the Cdx2 activationdomain mediates its transactivation capacity. Gastroenterology 121 1437-50. (Published).
• Gheorghiu I, Deschesnes C, Blais M, Boudreau F, Rivard N, Asselin C. (2001). Role of specific CCAAT/enhancer-binding protein isoforms in intestinalepithelial cells. J. Biol. Chem. 276 (4), 44331-337. (Published).
• Boudreau F, Zhu Y, Traber PG. (2001). Sucrase-isomaltase gene transcription requires HNF-1 regulatory elementand is regulated by the ratio of HNF-1b toHNF-1a. J. Biol. Chem. 276 (34), 32122-32128. (Published).
• (1999). Attenuation of haptoglobin gene expression by TGFbeta requires the MapKinase Pathway. Biochem. Biophys. Res. Commun. 259 (3), 544-549. (Published).
• Basora N, Herring-Gillam FE, Boudreau F, Perreault N, Pageot LP, Simoneau M, Bouatrouss Y, Beaulieu JF. (1999). Expression of functionally distinct variants of the beta(4)A integrinsubunit in relation to the differentiation state in human intestinal cells. J. Biol. Chem. 274 (42), 29819-825. (Published).
• Boudreau F, Zannoni S, Pelletier N, Bardati T, Asselin C. (1999). Negative regulation of glucocorticoid-dependent induction of c-fos byras in intestinal epithelial cells. Mol Cell Biochem. 195 (1), 99-111. (Published).
• Pelletier N, Boudreau F, Yu SJ, Zannoni S, Boulanger V, Asselin C. (1998). Activation of haptoglobin gene expression by cAMP involvesCCAAT/Enhancer binding protein isoforms in intestinal epithelial cells. FEBS Lett 439 (3), 275-280. (Published).
• Boudreau F, Yu SJ, Asselin C. (1998). CCAAT/Enhancer binding protein beta and delta regulate a1-acid-glycoprotein gene expression in rat intestinal epithelial cells. DNA Cell Biol 17 (8), 669-77. (Published).
• Morin C, Asselin C, Boudreau F, Provencher PH. (1998). Transcriptional regulation of pre-pro-endothelin-1-gene byglucocorticoids in vascular smooth muscle cells. Biochem. Biophys. Res. Commun 244 (2), 583-7. (Published).
• Zannoni S, Boudreau F, Asselin C. (1997). Phenotypic analysis of human fetal renal cells transformed by the SV40large T antigen. In Vitro Cellular & Developmental Biology 33 598-601. (Published).
• Arsalane K, Dubois CM, Muanza T, Begin R, Boudreau F, Asselin C, Cantin AM. (1997). Transforming growth factor beta-1 is a potent inhibitor of glutathione(GSH) synthesis in the lung epithelial cell line A549: Transcriptional effect on the GSHrate-limiting enzyme, gglutamylcysteinesynthetase. Am. J. Respir. Cell Mol. Biol. 17 599-607. (Published).
• Blais S, Boudreau F, Thorneloe K, Asselin C. (1996). Differential expression of FOS and JUN family members during murinepostnatal intestinal development. Biology of the Neonate 69 (Published).
• Boudreau F, Blais S., Asselin C. (1996). Regulation of CCAAT/Enhancer binding protein isoforms by serum andglucocorticoids in the rat intestinal epithelial crypt cell line IEC-6. Exp Cell Res 222 1-9. (Published).
• Blais S, Boudreau F, Asselin C. (1995). C/EBP isoforms expression in the developing murine colon. Dev Dyn 204 66-76. (Published).

Chapitres de livre

• JP Babeu and F Boudreau. (2017). Targeting the nuclear receptor HNF4alpha as a potential therapy for gut inflammation and cancer. Chi Hin Cho. Therapeutic Targets for Inflammation and Cancer: Novel Therapies for Digestive Diseases (77-97). Singapore : World Scientific. (Published).

Rapports

• Boudreau, F. (2015). Canadian Association of Gastroenterology Research Committee Report 2015. Canadian Association of Gastroenterology. 3 p.
• Boudreau, F., and Waschke, K. (2015). Canadian Association of Gastroenterology Visiting Research Professorship and Visiting Clinical Professorship. Canadian Association of Gastroenterology. 1 p.
• Boudreau, F. (2014). Canadian Association of Gastroenterology Research Committee Report 2014. Canadian Association of Gastroenterology. 3 p.

Autres contributions

Gestion d'évènements

• Member of the implementation committee. (2017) Canadian Digestive Diseases week (CDDW) 2017. (Conference).
• Member of the implementation committee. (2016) Canadian Digestive Diseases week (CDDW) 2016. (Conference).
• co-chair. (2015) BIT's 1st Annual World Congress of Digestive Diseases 2015: Forum 312: Digestive Tract Pathology, Physiology and Pathophysiology. (Conference).
• Member of the implementation committee. (2015) Canadian Digestive Diseases week (CDDW) 2015. (Conference).
• Chair. (2015) CIHR Institute of Nutrition, Metabolism and Diabetes New Investigator Meeting. Session: How to be a Successful Researcher. (Workshop).
• President. (2013) 10th Symposium on the Physiology and Diseases of the Digestive Tract (PDGI 2013). (Workshop).
• Co-chair. (2013) Small Group Session titled Omics/Bioinformatics, Canadian Digestive Diseases Week. (Workshop).
• Session Chair. (2012) LA RECHERCHE FONDAMENTALE EN CANCER DIGESTIF-Journée IROC- Session “LES CANCERS DE L’APPAREIL DIGESTIF”. (Conference).
• Co-chair. (2011) Session CANCER 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine”; Rhodes Island, Grèce. (Conference).
• Co-chair. (2011) Session “GUT INFLAMMATION” during “1st International Symposium on the Physiology and Diseases of the Digestive Tract. (Conference).
• Session Chair. (2011) CANCER ET SIGNALISATION lors du 79e Congrès de l’Acfas. (Conference).
• Chair. (2011) DOMAINE CANCER - 79E CONGRES DE L'ACFAS. (Conference).
• President. (2011) « La régulation des fonctions de l’épithélium digestif : du récepteur membranaire à l’expression génique » 79e Congrès de l’Acfas. (Workshop).
• President. (2011-2010) 1st International Symposium on the Physiology and Diseases of the Digestive Tract. (Workshop).
• President. (2009) 8e Symposium de Physiopathologie digestive, L’épithélium intestinal au centre de nouvelles thérapies. (Conference).
• Co-chair. (2009) GAG PAPER SESSION I-Canadian Digestive Diseases Week 2009. (Conference).

Présentations

• (2022). Role of nuclear receptor complexes during colorectal cancer. AAG Annual Conference-Keynote Speaker. Fox Harbour, Canada
• (2022). The nuclear receptor HNF4A and its multifaceted regulatory functions in gut epithelial homeostasis. Farncombe GI Noon Rounds. McMaster, Canada
• (2020). The intestinal epithelium and IBD: central roles for nuclear receptors. SickKids Cell Biology Seminar Series. Toronto, Canada
• (2019). A central role for the nuclear receptor HNF4alpha in the regulation of intestinal homeostasis. CSMB annual meeting. Montreal, Canada
• Girard R, Darsigny M, Jones C, Maloum-Rami, Noll C, Carpentier AC, Laplante M, Perreault N and Boudreau F. (2019). HNF4alpha and the intestinal control of incretins to fight against obesity. EMBO Workshop: Organ crosstalk in energy balance and metabolic disease (Abstract selected for oral presentation). Spain
• (2017). HNF4alpha nuclear receptor and its regulation of the intestinal stem cell niche. CDDW 2017. Canada
• (2016). Targeting the nuclear receptor HNF4alpha as a potential strategy for the treatment of colorectal cancer. SickKids GI Research Seminar Series. Toronto, Canada
• (2015). Roles distincts des isoformes de Hnf4alpha dans l'epithelium intestinal et le cancer colorectal. Weekly seminar series. Québec, Canada
• (2015). SPECIFIC ROLES FOR THE NUCLEAR RECEPTOR HNF4A ISOFORMS DURING INTESTINAL INFLAMMATION AND COLORECTAL CANCER. International Conference on Ulcer Research (ICUR) 2015. Ottawa, Canada
• (2015). Specific Roles for HNF4alpha P1 and P2 Isoforms in Intestinal Epithelium Maintenance and Pathophysiology. The 1st Annual World Congress of Digestive Diseases-2015. Nanjing, China
• (2014). Role of the NCOR1 transcriptional complex during intestinal inflammation. Seminar at McGill University, Department of Microbiology and Immunology. montreal, Canada
• (2014). Rôle de régulateurs de la transcription dans la progression du cancer colorectal. CONFÉRENCE INTERDISCIPLINAIRE SUR LE CANCER. sherbrooke, Canada
• François-Michel Boisvert. (2013). Small Group Session entitled "Omics/Bioinformatics". CDDW. Victoria, Canada
• (2013). The NCoR1 co-repressor integrates intestinal epithelial cell inflammatory signals. 8th Banff Inflammation Workshop. Banff, Canada
• (2012). Le répresseur transcriptionnel NCoR1 et son rôle dans l'intégration des signaux inflammatoires des cellules épithéliales intestinales. Invited speaker to "Signalisation Québec". Bécancour, Canada
• (2012). Roles for Hepatocyte Nuclear Factors 1 and 4 in the maintenance of intestinal epithelial fuctions. Invited guest to Vertex Pharmaceutical Canada. Montreal, Canada
• (2012). Selecting an Optimal Postdoctoral Position. Invited guest to the Trainee Workshop titled An Academic Pursuit, Canadian Digestive Diseases Week. Montreal, Canada
• (2011). Role of HNF4alpha isoforms during intestinal tumorigenesis. 1st International Symposium on the Physiology and Diseases of the Digestive Tract. Orford, Canada
• (2011). Role of the Pigment-Epithelial-Derived-Factor in regulating colorectal cancer cell growth and survival. Invited guest to the 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine. Rhodos, Greece
• (2010). HNF1alpha is crucial to control intestinal epithelial growth and differentiation in mice. Invited guest to the 15th World Congress on Advances in Oncology and 13th International Symposium on Molecular Medicine. Loutraki, Greece
• (2010). Hnf1alpha is required for proper gut epithelial endocrine cell specialisation and controls the mTOR signalling pathway in mice. Selected and invited for an oral presentation to Topic Session in Gastrointestinal Development and Disease. Experimental Biology 2010. Anaheim, United States
• (2010). Le role du facteur de transcription HNF1alpha dans le contrôle de la croissance et la différenciation de l’épithélium intestinal. Invited speaker to the Sainte-Justine Hospital Research Center, affiliated to the Université de Montréal. Montreal, Canada
• (2009). Les facteurs de transcription HNF1 et 4 comme régulateurs clés des fonctions épithéliales intestinales. Invited guest to the "Centre de recherche de L’Hôtel-Dieu de Québec". Québec, Canada
• (2009). L’épithélium intestinal et son rôle protecteur dans le contexte des maladies inflammatoires intestinales. Invited guest to a "Conférence organisée par la fondation canadienne des maladies inflammatoires de l'intestin". Québec, Canada
• (2009). Maladie de crohn et colite ulcéreuse : Comprendre les maladies inflammatoires de l’intestin pour un avenir en meilleure santé. Invited guest to a "Conférence organisée par la fondation canadienne des maladies inflammatoires de l'intestin". Sherbrooke, Canada
• (2009). New insights for the role of the nuclear receptor HNF4alpha during intestinal inflammation. Invited guest to the 3th world congress of Gene-2009. Track 12.4: anti-inflammation biotherapeutics. Foshan, China
• (2009). Rôles des facteurs de transcription HNF1 et 4 dans le contrôle de l'homéostasie intestinale. Invited guest to the Centre de Physiopathologie de Toulouse-Purpan. Unite 563. INSERM. Toulouse, France