Karl Fernandes

Prix et distinctions

• (2016) Renewal-Canada Research Chair. Université de Montréal. (Prix).
• (2015) Discovery of the Year. Research Center of the University of Montreal Hospital. (Prix).
• (2012) Canadian Foundation for Innovation-Leaders. Canadian Foundation for Innovation. (Prix).
• (2011) (R4) Canada Research Chair. Université de Montréal. (Prix).
• (2010) Alzheimer Society Young Investigator Award. Alzheimer Society of Canada. (Prix).
• (2005) (R3) Research Presentation Prize. Canadian Stem Cell Network. (Distinction).
• (1996) (R2) Graduate Student Symposium Award. Dept of Zoology, University of British Columbia. (Distinction).
• (1994) (R1) Magna cum laude. Université d'Ottawa. (Distinction).
• Personality of the Week. La Presse newspaper. (Honneur).

Financement

• Subvention. (Obtenu). Candidat principal. Genetic targeting of quiescent adult neural stem cells. Instituts de Recherche en Santé du Canada (IRSC). Project grants. 952 425 $. (2018-2023)
• Subvention. (Obtenu). Candidat principal. A new therapeutic target for correcting brain lipid metabolism in Alzheimer's disease. Société Alzheimer du Canada. Proof of concept, discovery. 100 000 $. (2021-2022)
• Subvention. (Obtenu). Candidat principal. Mechanisms of experience-dependent hippocampal neurogenesis. Conseil de Recherches en Sciences Naturelles et Génie du Canada (CRSNG). Discovery. 360 000 $. (2016-2022)
• Subvention. (Terminé). Candidat principal. Correction of brain triglyceride metabolism in Alzheimer's disease. Instituts de Recherche en Santé du Canada (IRSC). Project. 856 240 $. (2016-2021)
• Subvention. (Terminé). Cocandidat. Dichotomous actions of the IL-1 system in MS. Société Canadienne de la Sclérose en Plaques. Operating. 282 150 $. (2012-2015)
• Subvention. (Terminé). Chercheur principal. Regulation of endogenous stem cells during spinal cord disorders. Instituts de Recherche en Santé du Canada (IRSC). Operating grant. 627 952 $. (2011-2015)

Publications

Articles de revue

• *Pratesi F, *Hamilton LK, Fernandes KJL. (2021). Fast and gentle dissociation protocol for single cell RNA sequencing on the adult mouse brain. Submitted NA NA. (Article soumis).
• *Cochard, LM, *Levros L-C, *Joppe SE, *Pratesi F, *Aumont A, Fernandes KJLF. (2021). Manipulation of EGFR-induced signaling for the recruitment of quiescent neural stem cells in the adult mouse forebrain. Frontiers in Neuroscience NA (15:621076), NA. (Article publié).
• *Hamilton LK, Moquin-Beaudry G, *Mangahas CL, *Pratesi F, *Joppe SE, *Aumont A, Tetreault M, Fernandes KJL. (2021). SCD inhibition reverses immune, synaptic and behavioral deficits in an animal model of Alzheimer's disease. In revision (Nature Communications) NA NA. (Article soumis).
• Syal C, Kosaraju J, *Hamilton LK, *Aumont A, Chu A, Sarma SN, Thomas J, Seegobin M, Dilworth FJ, He L, Wondisford FE, Zimmermann R, Parent M, Fernandes KJL, Wang J. (2020). Dysregulated expression of monoglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer’s disease. Theranostics 10 (14), 6337-6360. (Article publié).
• *Joppe SE, *Cochard LM, *Levros L-C Jr, *Hamilton LK, *Ameslon P, *Aumont A, Fernandes KJL. (2020). Genetic targeting of neurogenic precursors in the adult forebrain ventricular epithelium. Life Sci Alliance 3 (7), e202000743. DOI. (Article publié).
• *Catherine-Alexandra Grégoire, Olivier Tastet, *Louis-Charles Levros, *Brianna L. Goldenstein, *Sandra E. Joppé, *Anne Aumont, Steve Lacroix, Karl J. L. Fernandes. (2020). Transcriptomic profiling reveals novel endogenous regulators of ependymal cell responses in the injured spinal cord. NA TBD TBD. (Article soumis).
• Li X, Floriddia EM, Toskas K, Chalfouh C, Honore A, *Aumont A, Vallières N, Lacroix S, Fernandes KJL, Guérout N, Barnabé-Heider F. (2018). FoxJ1 regulates spinal cord development and is required for the maintenance of spinal cord stem cell potential. Exp Cell Res 368 (1), 84-100. (Article publié).
• Flamier A, El Hajjar J, Adjaye J, Fernandes KJ, Abdouh M, Bernier G. (2018). Modeling Late-Onset Sporadic Alzheimer's Disease through BMI1 Deficiency. Cell Rep 23 (9), 2653-2666. (Article publié).
• *Laura K Hamilton, Karl J L Fernandes. (2018). Neural stem cells and adult brain fatty acid metabolism:lessons from the 3xTg model of Alzheimer’s disease. Biology of the Cell 110 (1), 6-25. (Article publié).
• *Catherine-Alexandra Grégoire, *Stephanie Tobin, *Brianna L. Goldenstein, Éric Samarut, *Andréanne Leclerc, *Anne Aumont, Pierre Drapeau, Stephanie Fulton, Karl J. L. Fernandes. (2018). RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus. Front Mol Neurosci 11 126. (Article publié).
• Li X, Floriddia EM, Toskas K, Fernandes KJL , Guérout N, Barnabé-Heider F. (2016). Regenerative potential of ependymal cells for spinal cord injury over time. EBioMedicine 13 55-65. (Article publié).
• *Hamilton LK, Dufresne M, *Joppé SE, Petryszyn S, *Aumont A, Calon F, Barnabé-Heider F, Furtos A, Parent M, Chaurand P, Fernandes KJL. (2015). Aberrant lipid metabolism within the forebrain niche suppresses adult neural stem cell proliferation in an animal model of Alzheimer's disease. Cell Stem Cell 17 1-15. (Article publié).
• *Joppe SE, *Hamilton LK, *Cochard LM, *Levros LC, *Aumont A, Barnabé-Heider F, Fernandes KJL. (2015). Bone morphogenetic protein dominantly suppresses epidermal growth factor-induced proliferative expansion of adult forebrain neural precursors. Frontiers in Neuroscience 9 407. (Article publié).
• *Gregoire CA, *Goldenstein B, Florridia E, Barnabé-Heider F, Fernandes KJL. (2015). Endogenous neural stem cell responses to stroke and spinal cord injury. Glia 63 (8), 1469-82. (Article publié).
• Lacroix S, *Hamilton LK, *Vaugeois A, *Beaudoin S, *Breault-Dugas C, Pineau I, Lévesque SA, *Grégoire CA, Fernandes KJ. (2014). Central canal ependymal cells proliferate extensively in response to traumatic spinal cord injury but not demyelinating lesions. PLoS One. 9 (1), e85916. (Article publié).
• *Grégoire CA, *Bonenfant D, *Le Nguyen A, *Aumont A, Fernandes KJ. (2014). Untangling the influences of voluntary running, environmental complexity, social housing and stress on adult hippocampal neurogenesis. PLoS One. 9 (1), e86237. (Article publié).
• *L Hamilton, *SE Joppé, L *Cochard, KJL Fernandes. (2013). Aging and neurogenesis in the adult forebrain: what we have learned and where we should go from here. European Journal of Neuroscience 37 (12), 1978-86. (Article publié).
• V El-Helou, A Chabot, H Gosselin, L Villeneuve, M-E Clavet-Lanthier, J-F Tanguay, G Enikolopov, KJL Fernandes, J-F Jasmin A Calderone. (2013). Cardiac resident nestin+ cells participate in reparative vascularisation. Journal of Cellular Physiology 228 (9), 1844-53. (Article publié).
• Cournoyer S, Nyalendo C, Addioui A, Belounis A, Beaunoyer M, Aumont A, Teira P, Duval M, Fernandes KJL, Fetni R, Haddad E, Sartelet H. (2012). Genotype analysis of tumour initiating cells expressing CD133 in neuroblastoma. Genes, Chromosomes and Cancer 51 (8), 792-804. (Article publié).
• *Paliouras GN, *Hamilton LK, Aumont A, *Joppé SE, Barnabé-Heider F, Fernandes KJL. (2012). mTOR signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. Journal of Neuroscience 32 (43), 15012-26. (Article publié).
• *Bouab M, *Paliouras GN, Aumont A, *Forest-Berard K, Fernandes KJL. (2011). Aging of the subventricular zone neural stem cell niche: evidence for quiescence-associated changes between early and mid-adulthood. Neuroscience 173 135-49. (Article publié).
• *Bednarczyk MR, *Hacker LC, *Fortin-Nunez S, Aumont A, Bergeron R, Fernandes KJL. (2011). Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment. Hippocampus 21 (12), 1334-47. (Article publié).
• *Hamilton LK, Aumont A, Julien C, *Vadnais A, Calon F, Fernandes KJL. (2010). Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease. Eur J Neurosci 32 (9), 905-20. (Article publié).
• *Hamilton LK, *Truong MKV, *Bednarczyk MR, Aumont A, Fernandes KJL. (2009). Cellular organization of the central canal ependymal zone, a niche of latent neural stem cells in the adult mammalian spinal cord. Neuroscience 164 1044-1056. (Article publié).
• *Bednarczyk MR, Aumont A, Decary S, Bergeron R, Fernandes KJL. (2009). Prolonged voluntary wheel-running stimulates neural precursors in the hippocampus and forebrain of adult CD1 mice. Hippocampus 19 (10), 913-927. (Article publié).
• (A12) Fernandes KJL, Toma JG, Miller FD. (2008). Multipotent skin-derived Precursors: adult neural crest-related precursors with therapeutic potential. Philos Trans R Soc Lond B Biol Sci. 363 (1489), 185-98. (Article publié).
• (A13) El-Helou V, Beguin PC, Assimakopoulos J, Clement R, Gosselin H, Brugada R, Aumont A, Biernaskie J, Villeneuve L, Fernandes KJL, Calderone A. (2008). The rat heart contains a neural stem cell population; role in sympathetic sprouting and angiogenesis. Journal of Molecular and Cellular Cardiology 45 (5), 694-702. (Article publié).
• (A11) Fernandes KJL*, Kobayashi NR*, Gallagher CJ, Barnabé-Heider F, Aumont A, Kaplan DR, Miller FD. (2006). Analysis of the neurogenic potential of multipotent Skin-derived Precursors. Exp Neurol 201 (1), 32-48. (Article publié).
• (A9) Nadeau S*, Hein P*, Fernandes KJL, Peterson AC, Miller FD. (2005). A transcriptional role for C/EBP beta in the neuronal response to axonal injury. Mol Cell Neurosci 29 (4), 525-535. (Article publié).
• (A10) Barnabé-Heider F, Wasylnka JA, Fernandes KJL, Porsche C, Sendtner M, Kaplan DR, Miller FD. (2005). Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1. Neuron 48 253-265. (Article publié).
• (A8) Fernandes KJL*, McKenzie IA*, Mill P, Smith K, Akhavan M, Barnabé-Heider F, Biernaski J, Junek A, Kobayashi NR, Toma JG, Kaplan DR, Labosky PA, Rafuse V, Hui CC, Miller FD. (2004). A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol 6 (11), 1082-1093. (Article publié).
• (A7) McPhail LT, Fernandes KJL, Chan CCM, Vanderluit JL, Tetzlaff W. (2004). Axonal re-injury reveals the survival and re-expression of regeneration associated genes in chronically axotomized adult mouse motoneurons. Exp Neurol 188 (2), 331-40. (Article publié).
• (A6) Vanderluit JL, McPhail LT, Fernandes KJL, Kobayashi NR, Tetzlaff W. (2003). In vivo application of mitochondrial pore inhibitors blocks the induction of apoptosis in axotomized neonatal facial motoneurons. Cell Death Diff 10 969-976. (Article publié).
• (A5) Toma JG, Akhavan M*, Fernandes KJL*, Barnabe-Heider F, Sadikot A, Kaplan DR, Miller FD. (2001). Isolation of multi-potent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3 (9), 778-784. (Article publié).
• (A4) Vanderluit JL, McPhail LT, Fernandes KJL, McBride CB, Huguenot C, Roy S, Roberson GS, Nicholson DW, Tetzlaff W. (2000). Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents. Eur J Neurosci 12 3469-3480. (Article publié).
• (A3) Pataky DM, Borisoff JF, Fernandes KJL, Tetzlaff W, Steeves JD. (2000). Fibroblast growth factor treatment produces differential effects on survival and neurite outgrowth from identified bulbospinal neurons in vitro. Exp Neurol 163 (2), 357-372. (Article publié).
• (A2) Fernandes KJL, Fan D-P, Tsui BJ, Cassar SL, Tetzlaff W. (1999). Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. J Comp Neurol 414 495-510. (Article publié).
• (A1) Fernandes KJL, Kobayashi NR, Jasmin BJ, Tetzlaff W. (1998). Acetylcholinesterase gene expression in axotomized rat facial motoneurons is differentially regulated by neurotrophins: correlation with trkB and trkC mRNA levels and isoforms. J Neurosci 18 9936-9947. (Article publié).

Chapitres de livre

• Laura K. Hamilton Karl J. L. Fernandes. (2017). Fate through fat: lipids as regulators of neural stem cell behaviour. Alice Pebay Raymond Wong. Lipidomics of Stem Cells (87-116). États-Unis : Springer. (Article publié).

Propriétés intellectuelles

Brevets

• Cellular composition for use in the treatment and repair of bone and nervous system disorders. États-Unis. (Délivré).
• Methods of Making and Using Skin-Derived Stem Cells. États-Unis. (Délivré).
• Multipotent stem cells from peripheral tissues and uses thereof. États-Unis. (Délivré).

Autres contributions

Présentations

• (2021). Brain lipid metabolism as a therapeutic target in Alzheimer's disease. Institut de Gériatrie - Seminar series. Sherbrooke, Canada
• (2021). Correction of aberrant brain fatty acid metabolism in Alzheimer's disease. Cell and experimental biology 2021. États-Unis
• (2021). Recruiting quiescent neural stem cells in the injured spinal cord via targeted modulation of the post-injury inflammatory milieu. Canadian Association for Neuroscience. Montreal, Canada
• (2020). Brain lipid metabolism as a therapeutic target in Alzheimer's disease. Centre for Advanced Research in Sleep Medicine: Seminar series. Montreal, Canada
• (2019). Brain lipid metabolism and the pathogenesis of Alzheimer’s disease. Seminar series. Kingston, Canada
• (2019). New insights into the pathogenesis of Alzheimer’s disease. Recruitment seminar. Sherbrooke, Canada
• (2019). Stem cells, lipids and the pathogenesis of Alzheimer’s disease. Recruitment seminar. Sherbrooke, Canada
• (2018). Biological properties of dormant neural stem cells revealed by genetic targeting in the adult murine brain. Canadian Association for Neuroscience, Satellite Symposium: Neural stem cells in development and adulthood. Canada
• (2017). Identification and correction of brain fatty acid abnormalities in Alzheimer's disease. Biogen seminar. Boston, États-Unis
• (2017). Identification and correction of brain fatty acid abnormalities in Alzheimer's disease. Lipids and Brain Symposium. Nancy, France
• (2017). Lipid metabolism in adult neural stem cell biology and AD. Annual Meeting of the American Society for Neurochemistry. Little Rock, États-Unis
• (2017). Lipid metabolism in adult neural stem cell biology and Alzheimer's disease. AD/PD Meeting. Vienna, Autriche
• (2017). Mechanisms and consequences of lipid metabolism disturbances in Alzheimer's disease. EMBO Annaberg Workshop. Annaberg, Autriche
• (2017). Neural stem cell dysregulation by aberrant brain fatty acid metabolism in Alzheimer's disease. Till and McCulloch Symposium. Mont Tremblant, Canada
• (2017). Recruiting dormant stem cells in the diseased brain. UAlberta MS Centre Research Symposium. Edmonton, Canada
• (2017). Waking dormant stem cells in the diseased brain. NMHI Seminar Series. Edmonton, Canada
• (2016). Neural stem cell activation in the diseased and injured nervous system. Dalhousie University. Halifax, Canada
• (2016). Neural stem cell proliferation is suppressed by aberrant niche fatty acid metabolism in an animal model of Alzheimer’s disease. Annual Meeting of the Society for Neuroscience. San Diego, États-Unis
• (2016). New insights into the pathogenesis of Alzheimer's. CRCHUM Conference. Montreal, Canada
• (2016). New insights into the pathogenesis of Alzheimer's disease. Department of Pharmacology and Therapeutics, McGill. Montreal, Canada
• (2016). New insights into the pathogenesis of Alzheimer's disease. Lady Davis Institute for Medical Research, McGill. Montreal, Canada
• (2016). New insights into the pathogenesis of Alzheimer's disease. CRCHUM Retreat-Contribution of the Year. Montreal, Canada
• (2016). New insights into the pathogenesis of Alzheimer's disease. Memorial University. St. John's, Canada
• (2016). New insights into the pathogenesis of Alzheimer's disease. Bellairs Research Conference. Bellairs, Barbade
• (2015). Aberrant fatty acid metabolism at the brain-CSF barrier in Alzheimer's disease. Keystone Symposium: Systems Biology of Lipid Metabolism. Keystone, États-Unis
• (2015). Neural stem cell quiescence. Carleton University. Ottawa, Canada
• (2015). New insights into the pathogenesis of Alzheimer's disease. Center for Research in Neuroscience, McGill. Montreal, Canada
• (2015). Stem cells, lipid metabolism, and the pathogenesis of Alzheimer's disease. Seminar series. Montreal, Canada
• (2015). Stem cells, lipids, and the pathogenesis of Alzheimer's disease. AFIRMAQ Annual Retreat. Montreal, Canada
• (2015). Stem cells, lipids, and the pathogenesis of Alzheimer's disease. 11th Annual International Bellairs Research Workshop. Barbados, Barbade
• (2014). Dreams of immortality: a glimpse into the world of stem cells. St James Literary Society. Montreal, Canada
• (2014). Pour le meilleur et pour le pire: Neural stem cells in health, aging and disease. CRCHUM Annual Retreat. Montreal, Canada
• (2013). Neural stem cell dynamics in health, aging and disease. Annual meeting of the Canadian Neurological Sciences Federation. Montreal, Canada
• (2013). Neural stem cell dynamics in the adult and aging brain. University of Montreal (Biochemistry) seminar series. Montreal, Canada
• (2013). Neural stem cell dynamics in the adult and aging brain. Robert Giffard seminar series. Quebec City, Canada
• (2012). Adult neural stem cells: preserving a fountain of youth in the aging brain. Karolinska Institute. Stockholm, Suède
• (2012). Defining the signaling pathways that mediate stem cell quiescence in the aging and Alzheimer brain. GRSNC international symposium: Aging and Alzheimer’s disease, walking down the same road?. Montreal, Canada
• (2012). Molecular regulation of neural stem cells in the adult and aging brain. Cellular and Molecular Medicine, University of Ottawa. Ottawa, Canada
• (2012). Molecular regulation of neural stem cells in the adult and aging brain: key roles for mTOR signalling. International Society for Developmental Neuroscience. Mumbai, Inde
• (2012). Physiological regulation of stem cells in the adult CNS. Centre for Studies in Behavioural Neurobiology. Montreal, Canada
• (2012). Stem cell regulation in the adult central nervous system. Dept of Molecular and Cellular Biology, McGill University. Montreal, Canada
• (2011). Running to the fountain of youth: regulation of stem cells in the aging brain. UQAM. Montreal, Canada
• (2011). The fountain of youth: neural stem cells in the aging brain. Canadian Association for Neuroscience. Quebec, Canada
• (2011). Unlocking the fountain of youth: signalling pathways controlling neural stem cells in the aging and Alzheimer brain. Hôpital St. Justine. Montreal, Canada
• (2009). Cellular organization of the ependymal zone, the stem cell niche of the adult spinal cord. Canadian Association for Neuroscience. Vancouver, Canada
• (2009). Physiological and pathological regulation of CNS stem cells. Lady Davis Institute, McGill University. Montreal, Canada
• (2009). Physiological and pathological regulation of CNS stem cells. Dept of Anatomy and Cell Biology, McGill University. Montreal, Canada
• (2009). Stem cells and their niches in the adult CNS : regulation by physiological and pathological processes. Memorial University. St John's, Canada