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Rona Graham

Professeure, Faculté de médecine et des sciences de la santé
FMSS Département de pharmacologie-physiologie

Présentation

Sujet de recherche

Aging Process, Apoptosis, Cell Signaling, Neurodegenerative Diseases, Proteins

Disciplines de recherche

Molecular Biology, Neurosciences

Mots-clés

Apoptosis/Cell death, Caspases, Cell models, Genetics, Huntington disease, Immunohistochemistry, Molecular Biology, Mouse models, Neurodegeneration, Neuropathology

Intérêts de recherche

Neurodegenerative conditions; models of neurodegeneration and therapeutic approaches; caspase biology and cell death pathways including the regulation of caspases and caspase interactome studies

Centre de recherche

(None)

Langues parlées et écrites

Anglais, Français

Diplômes

(2011). (Post-doctorate, Post Doctoral Fellow). University of British Columbia.

(2006). (Doctorate, Ph.D). University of British Columbia.

(1987). (Bachelor's, B.Sc). Concordia University.

Prix et distinctions

  • (2017) Canada Research Chair Research Award. (Prize / Award).
  • (2009) Post Doctoral Fellowship Research Award. Michael Smith Foundation for Health Research. (Prize / Award).
  • (2009) CMMT Champion Award. (Distinction).

Publications

Articles de revue

  • Biet M., Morin N., Lessard-Beaudoin M., Graham R.,Carmant L., Dumaine R. (2015). Increased contribution of tetrodotoxin-sensitive sodium current to cardiac action potential as a mechanism for sudden death in epilepsy. Circ Arrhythm Electrophysiol 8 (4), 912-920. (Published).
  • Stroedicke M, Bounab Y, Chaurasia G, Li S, Plabmann S, Russ J, Nicoletti C, Bieschke J, Schnoegl S, Graham RK, et al. (2015). Systematic interaction network filtering identifies CRMP1 asa novel suppressor of huntingtin misfolding and neurotoxicity. Genome Res 25 (5), 701-713. (Published).
  • Bibiana K Wong, PhD; Dagmar Elisabeth Ehrnhoefer, Ph.D.; Rona K Graham, PhD; Dale D Martin, PhD; Safia Ladha; Valeria Uribe, MSci; Lisa M Stanek, PhD; Sonia Franciosi, PhD; Xiaofan Qiu; Yu Deng; Vlad Kovalik; Weining Zhang; Mahmoud A Pouladi, PhD; Lamya S Shihabuddin, PhD; Michael R Hayden. (2015). Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice. Neurobiology of disease 76 24-36. (Published).
  • Mélissa Lessard-Beaudoin, Mélissa Laroche, Marie-Josée Demers, Guillaume Grenier and Rona K.Graham. (2015). Characterisation of age-associated changes in peripheral organ and brain regions weights in C57BL/6 mice. Experimental Gerontology 63 27-34. (Published).
  • Butland SL, Sanders SS, Schmidt ME, Riechers SP, Lin DT, Martin DD, Vaid K, Graham RK, Singaraja RR, Wanker EE, Conibear E, Hayden MR. (2014). The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Human Molecular Genetics 23 (15), 4142-4160. (Published).
  • Marco S , Giralt A , Petrovic MM , Pouladi MA , Martínez-Turrillas R , Martínez-Hernández J , Kaltenbach LS , Torres-Peraza J , Graham RK , Watanabe M , Luján R , Nakanishi N , Lipton SA , Lo DC , Hayden MR , Alberch J , Wesseling JF , Pérez-Otaño I. (2013). Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nature medicine 19 (8), 1030-8. (Published).
  • Rona K. Graham, Yu Deng, Mahmoud A. Pouladi, Kuljeet Vaid, Dagmar Ehrnhoefer, Amber Southwell, Nagat Bissada, Sonia Franciosi and Michael R. Hayden. (2012). Caspase-6-resistant mutant huntingtin does not rescue the toxic effects of caspase-cleavable mutant huntingtin in vivo. Journal of HD 1 (2), 243-260. (In Press).
  • Pouladi MA , Brillaud E , Xie Y , Conforti P , Graham RK , Ehrnhoefer DE , Franciosi S , Zhang W , Poucheret P , Compte E , Maurel JC , Zuccato C , Cattaneo E , Néri C , Hayden MR. (2012). NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease. Neurobiology of disease 48 (3), 282-9. (Published).
  • Uribe V , Wong BK , Graham RK , Cusack CL , Skotte NH , Pouladi MA , Xie Y , Feinberg K , Ou Y , Ouyang Y , Deng Y , Franciosi S , Bissada N , Spreeuw A , Zhang W , Ehrnhoefer DE , Vaid K , Miller FD , Deshmukh M , Howland D , Hayden MR. (2012). Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice. Human molecular genetics 21 (9), 1954-1967. (Published).
  • Waldron-Roby E , Ratovitski T , Wang X , Jiang M , Watkin E , Arbez N , Graham RK , Hayden MR , Hou Z , Mori S , Swing D , Pletnikov M , Duan W , Tessarollo L , Ross CA. (2012). Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin. The Journal of neuroscience 32 (1), 183-193. (Published).
  • Graham RK , Ehrnhoefer DE , Hayden MR. (2011). Caspase-6 and neurodegeneration. Trends in neurosciences 34 (12), 646-656. (Published).
  • Carroll JB , Southwell AL , Graham RK , Lerch JP , Ehrnhoefer DE , Cao LP , Zhang WN , Deng Y , Bissada N , Henkelman RM , Hayden MR. (2011). Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease. Molecular neurodegeneration 6 (59), 2-12. (Published).
  • Graham RK , Deng Y , Carroll J , Vaid K , Cowan C , Pouladi MA , Metzler M , Bissada N , Wang L , Faull RL , Gray M , Yang XW , Raymond LA , Hayden MR. (2010). Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo. The Journal of neuroscience 30 (45), 15019-15029. (Published).
  • Metzler M , Gan L , Mazarei G , Graham RK , Liu L , Bissada N , Lu G , Leavitt BR , Hayden MR. (2010). Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A. The Journal of neuroscience 30 (43), 14318-14329. (Published).
  • Pouladi MA , Xie Y , Skotte NH , Ehrnhoefer DE , Graham RK , Kim JE , Bissada N , Yang XW , Paganetti P , Friedlander RM , Leavitt BR , Hayden MR. (2010). Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression. Human molecular genetics 19 (8), 1528-1538. (Published).

Chapitres de livre

  • Simon C Warby, Rona K Graham and Michael R Hayden. (2014). Huntington disease. GeneReviews University of Washington, Seattle (WA). (Published).
  • Simon C Warby, Rona K Graham and Michael R Hayden. (2010). Huntington Disease. GeneReviews™ (website). University of Washington, Seattle (WA). (Published).

Articles de conférence

  • Anthony Pinçon, Stefano Cataldi, Melissa Laroche, Melissa Lessard-Beaudoin, Marie-Josée Demers, Matthew J Farrer, Austen Milnerwood and Rona K Graham. (2015). Potential role of apoptosis and inflammation in the olfactory dysfunction and altered neurogenesis in humanwild type LRRK2 transgenic PD mice. Gordon Research Conference - Parkinson Disease. (Published).
  • M Laroche, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidyi, K Yu-Tager, H Nguyen, MR Hayden, MA Pouladi and RK Graham. (2015). Caspase activation in the olfactory bulb andalterations in neurogenesis observed early in HD rodent models. Society for Neuroscience. (Accepted).
  • M Laroche, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidyi, K Yu-Tager, H Nguyen, MR Hayden, MA Pouladi and RK Graham. (2015). Le rôle du déclin précoce du système olfactif dans lamaladie de Huntington. University of Sherbrooke - Research Day. (Published).
  • M Lessard-Beaudoin, MJ Demers, M Laroche1, G Grenier and RK Graham. (2015). The role of STK3 in neurodegeneration: Brain region-specific alterations in the aging process. Society of Neuroscience Conference. (Accepted).
  • M Lessard-Beaudoin, MJ Demers, M Laroche1, G Grenier and RK Graham. (2015). The role of STK3 in neurodegeneration: Brain region-specific alterations in the aging process. University of Sherbrooke - Research Day. (Published).
  • M Laroche, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidyi, K Yu-Tager, H Nguyen, MR Hayden, MA Pouladi and RK Graham. (2015). Caspase activation in the olfactory bulb and alterations in neurogenesis observed early in HD rodent models. Research Center on Aging - Research Day. (Accepted).
  • M Laroche, MA Pouladi, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidy, S Franciosi, MR Hayden and RK Graham. (2014). Huntington disease and olfactory dysfunction: structural abnormalities of the olfactory system and early caspase activation in the olfactory bulb are observed in HD mouse models. Society for Neuroscience Conference. (Accepted).
  • NH Skotte, MA Pouladi, K Huynh, TT Nielsen, RK Graham, A Nørremølle and MR Hayden. (2014). Insulin-like growth factor 1 signalling in Huntington'sdisease. Society for Neuroscience Conference. (Published).
  • M. Laroche, M.-J. Demers, M. Lessard-Beaudoin et R.K. Graham. (2014). Le rôle du déclin précoce du système olfactif dans la maladie de Huntington. Club de Recherches Cliniques du Quebec. (Published).
  • M Laroche, MA Pouladi, MJ Demers, M Lessard-Beaudoin, M Garcia-Miralles, C Kreidy, S Franciosi, MR Hayden and RK Graham. (2014). Huntington disease and olfactory dysfunction: structural abnormalities of the olfactory system and early caspase activation in the olfactory bulb are observed in HD mouse models. European Huntington disease Network. (Accepted).
  • MJ Demers, K Girling, S Zhang, YT Wang and RK Graham. (2014). Activation of caspase-6 and cleavage of STK3 in an early event in an in vitro model of stroke. Canadian Neuroscience Meeting. (Accepted).
  • M Lessard-Beaudoin,MJ Demers, M Laroche1, G Grenier and RK Graham1. (2014). Age-related changes in brain region weights are associated with caspase activation in wild type C57Bl6 mice. Canadian Neuroscience Meeting. (Accepted).
  • M Lessard-Beaudoin, MJ Demers, M Laroche, G Grenier et R Graham. (2014). Deux nouveaux substrats de la caspase-6, DAXX et STK3, voient leur expression modifiée avec le vieillissement. University of Sherbrooke Research Day. (Accepted).
  • M. Laroche, M.-J. Demers, M. Lessard-Beaudoin et R.K. Graham. (2014). Le rôle du déclin précoce du système olfactif dans la maladie de Huntington. University of Sherbrooke Research Day. (Accepted).
  • MJ Demers, K Girling, S Zhang, YT Wang et RK Graham. (2013). L'activation précoce de la caspase-6 et le clivage des substrats dans un modèle in vitro d'accident vasculaire cérébral. Club de Recherches Cliniques du Quebec. (Published).
  • MJ Demers, K Girling, S Zhang, YT Wang and RK Graham. (2013). Early activation of caspase-6 and cleavage of caspase-6 substrates in an in vitro model of stroke. Society for Neuroscience Conference. (Accepted).
  • MJ Demers, K Girling, S Zhang, YT Wang and RK Graham. (2013). Early activation of caspase-6 and cleavage of caspase-6 substrates in an in vitro model of stroke. The International Society of Autonomic Neuroscience:. (Published).
  • MJ Demers, M Laroche, G Grenier and RK Graham. (2013). The role of apoptotic mechanisms in the pathophysiology of aging. The International Society of Autonomic Neuroscience. (Published).
  • Rona K. Graham, Sean-Patrick Riechers, Stefanie Butland, Yu Deng, Niels Skotte, Jenny Russ, Vinayagam Arunachalam, Erich Wanker and Michael R. Hayden. (2012). Characterization of the caspase-6 interactome identifies novel substrates that play a role in the pathogenesis of HD. Canadian Neuroscience Meeting. (Published).
  • Rona K. Graham, Sean-Patrick Riechers, Stefanie Butland, Yu Deng, Niels Skotte, Jenny Russ, Vinayagam Arunachalam, Erich Wanker and Michael R. Hayden. (2012). Characterization of the caspase-6 interactome identifies novel substrates that play a role in the pathogenesis of HD. Quebec symposium on neurodegenerative disease therapeutics. (Published).
  • Rona K. Graham, Mahmoud A. Pouladi, Yu Deng, Yuanyun Xie, Nagat Bissada and Michael R. Hayden. (2011). Huntington disease phenotypes influenced by cleavage of huntingtin at aa586: further characterization of HD YAC128 mice expressing caspase-6-resistant mutant hungtintin. Society of Neuroscience. (Published).
  • N. H. Skotte, M. Pouladi, T. Tolstrup Nielsend, R. Graham, M. Hayden. (2011). Modulation of aberrant caspase-6 activity by insulin-like growth factor 1 in Huntington’s disease. Society for Neuroscience Conference. (Published).
  • B. K. Wong, V. Uribe, R. Graham, C. L. Cusack, N. Skotte, M. Pouladi, Y. Xie, Y. Deng, D. Ehrnhoefer, S. Franciosi, N. Bissada, A. Spreeuw, W. Zhang, K. Vaid, M. Deshmukh, D. Howland, M. R. Hayden. (2011). Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuropathological alterations in caspase-6 deficient mice. Society for Neuroscience Conference. (Published).
  • E. A. Waldron, T. Ratovitski, X. Wang, M. Jiang, R. K. Graham, M. R. Hayden, S. Mori, D. Swing, M. Pletnikov, W. Duan, L. Tessarollo, C. A. Ross. (2011). Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin. Society for Neuroscience Conference. (Published).
  • Marco S, Torres-Peraza J, Giralt A, Graham R K, Hayden M R, Alberch J, Pérez-Otaño I. (2011). Disrupted NMDA receptor trafficking underlies sPINE LOSS in Huntington’s disease models. Spanish Ion Channel Initiative Meeting. (Published).
  • Rona K. Graham, Mahmoud A. Pouladi, Yu Deng, Yuanyun Xie, Nagat Bissada and Michael R. Hayden. (2011). Huntington disease phenotypes influenced by cleavage of huntingtin at aa586: further characterization of HD YAC128 mice expressing caspase-6-resistant mutant hungtintin. Canadian Neuroscience Meeting. (Published).
  • Graham R K, Deng Y, Pouladi M A, Vaid K, Xie Y, Bissada N, Franciosi S, Hayden M R. (2010). Caspase-6-resistant mutant huntingtin does not rescue the toxic effects of caspase-cleavable mutant huntingtin in vivo. 2010 Medical Genetics Research Day. (Published).
  • Graham R K, Deng Y, Pouladi M A, Vaid K, Xie Y, Bissada N, Franciosi S, Hayden M R. (2010). Caspase-6-resistant mutant huntingtin does not rescue the toxic effects of caspase-cleavable mutant huntingtin in vivo. 40th Annual meeting of Neuroscience. (Published).
  • Menalled L B, Kudwa A, Miller S, Graham R K, et al. (2010). Human huntingtin supplementation ameliorated deficits detected in murine huntingtin knock down mice. 40th Annual meeting of Neuroscience. (Published).
  • Uribe V, Graham R K, Wong B, Ehrnhoefer D, Deng D, Vaid K, Franciosi S, Bissada N, Howland D, Hayden M R. (2010). Medium spiny neurons derived from caspase-6 knockout mice striatum demonstrate protection against excitotoxic stress. 40th Annual meeting of Neurosicence. (Published).
  • Waldron E A, Ratovitski T, Chighladze E, Tebbenkamp A T, Graham R K, Hayden M R, Borchelt D R, Ross C A. (2010). Transgenic HD mouse model expressing the putative caspase 6 derived huntingin fragment. 40th Annual meeting of Neuroscience. (Published).

Autres contributions

Gestion d'évènements

  • Organizer. CDRV Scientific Research day. (Conference).
  • Organizing committee member. International Symposium «The Challenges of Biological Research in Aging on the 21st century: From Cells to Clinics». (Conference).
  • Executive committee member. Theme porteur vieillissement - held every 3 months. (Seminar).
  • Judge. University of Sherbrooke research day. (Conference).

Activités de collaboration internationale

  • Collaborator. Collaboration with Professor Pouladi regarding olfactory deficits in HD.
  • Collaborator. Collaboration with Professor Wanker in Germany for identification of caspase-6 proteome using the yeast-2-hybrid assay.

Présentations

  • (2014). The role of apoptotic mechanisms in the pathophysiology of Alzheimer's disease. Alzheimer's Disease and Dementia. Valencia
  • (2012). Les Caspases et la Neurodégénérescence. CNS Conference. Sherbrooke
  • (2012). Characterization of the caspase-6 interactome identifies novel substrates that play a role in the pathogenesis of HD. Society for Neuroscience Conference. New Orleans
  • (2012). Caspases and Neurodegeneration. Center for Neuroscience at Sherbrooke seminar. sherbrooke
  • (2012). Rôle de la caspase-6 dans la pathogénèse des maladies neuro-dégénératives. Seminar, Center for Research on Aging. sherbrooke
  • (2010). The role of caspase-6 and cleavage of huntingtin in the pathogenesis of Huntington disease. University of Washington.
  • (2009). Proteolysis of huntingtin and its role in the pathogenesis of HD. World HD Congress.
  • (2009). Proteolysis of huntingtin and its role in the pathogenesis of Huntington disease. Max Delbrueck Center for Molecular Medicine.