Véronique Giroux

Prix et distinctions

• (2016) Post-doctoral Fellowship - Renewal. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
• (2015) Post-doctoral Fellowship. Fonds de recherche du Québec - Santé (FRQS). (Prize / Award).
• (2012) PhD Fellowship - Best and Banting. Canadian Institutes of Health Research. (Prize / Award).
• AACR-Abbvie Scholar-in-Training Award. American Association for Cancer Research. (Prize / Award).
• Dean's List. Université de Sherbrooke. (Honor).
• Dean's List. Université de Sherbrooke. (Honor).
• Gilles Dupuis Award. Université de Sherbrooke. (Prize / Award).
• Honour from the Government of Quebec for Excellence - Lieutenant-Gouverneur Medal. Gouvernement du Québec. (Distinction).
• Jean-Pierre-Caillé Award. Université de Sherbrooke. (Prize / Award).
• REMDUS Prize. Université de Sherbrooke. (Prize / Award).

Financement

• Research Chair. (Under Review). Principal Investigator. Canada Research Chair Tier 2 in Gastrointestinal Stem Cell Biology. (2018-2023)
• Grant. (Awarded). Principal Investigator. Start-up Fund - Research Assistant Salary. (2018-2020)
• Grant. (Awarded). Principal Investigator. Start-up Fund. (2018-2020)
• Grant. (Awarded). Principal Investigator. Start-up Fund. (2018-2020)
• Grant. (Awarded). Principal Investigator. Start-up Fund. (2018-2020)
• Grant. (Under Review). Principal Investigator. Imaging of stem cells in the digestive tract. (2018)
• Fellowship. (Completed). Principal Investigator. Role of keratin 15 in esophageal epithelium. (2015-2016)
• Fellowship. (Completed). Principal Investigator. Esophageal stem cells and their role in esophageal development. (2013-2015)
• Scholarship. (Completed). Principal Investigator. Role of Estrogen-Related Receptor Alpha in intestinal epithelium. (2009-2012)
• Scholarship. (Declined). Principal Investigator. Rôle d'ERRalpha dans la carcinogenèse intestinale. (2009-2012)
• Scholarship. (Completed). Principal Investigator. (2008-2008)
• Scholarship. (Completed). Principal Investigator. (2004-2004)
• Scholarship. (Completed). Principal Investigator. (2003-2003)

Publications

Articles de revue

• Giroux V, Stephan J, Chatterji P, Rhoades B, Wileyto EP, Klein-Santo AJ, Lengner CJ, Hamilton KE, Rustgi AK. (2018). Mouse intestinal Krt15+ cells are radio-resistant and tumor-initiating cells. Stem Cell Reports 10 (6), 1947-58. (Published).
• Kasagi Y, Chandramoulesswaran P, Whelan KA, Tanaka K, Giroux V, Sharma M, Wang J, Benitez AJ, DeMarshall M, Tobias J, Hamilton KE, Falk GW, Spergel JM, Klein-Szanto AJ, Rustgi AK, Muir AB, Nakagawa H. (2018). The esophageal organoid system reveals functional interplay between Notch and cytokines in reactive epithelial changes. Cellular and Molecular Gastroenterology and Hepatology 5 (3), 333-52. (Published).
• Kojima T, Nakagawa H, Chandramouleeswaran P, Kita Y, Tanaka K, KAsagi Y, Kikuchi O, Giroux V, Sasaki K, Omoto I, Shinden Y, Whelan KA, Muir AB, Ahashi S, Naganuma S, Klein-Santo AJ, Muto M, Bass A, Diehl AJ, Ochikago Y, Origami T, Rustgi AK, Natsugoe S. (2018). Three-dimensional organoids reveal therapy resistance of esophageal squamous cell carcinoma cells. Cellular and Molecular Gastroenterology and Hepatology NA NA. (Revision Requested).
• Whelan KA, Merves JF, Giroux V, Blair A, Benitez AJ, Guo A, Chandramouleeswaran PM, Chang S, Dods K, Tanaka K, Que J, Masterson JC, Fernando SD, Klein-Szanto AJ, Ruchelli ED, Chikwava K, Muir AB, Furuta GT, Wang ML, Falk GW, Gimotty PA, Spergel JM, Nakagawa H. (2017). Autophagy mediates epithelial cytoprotection in Eosinophil Oesophagitis. Gut 66 (7), 1197-1207. (Published).
• Natsuizaka M, Whelan KA, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, Long A, Darling D, Que J, Yang Y, Katz J, Wileyto EP, Basu D, Kita Y, Natsugoe S, Naganuma S, Klein-Szanto AJ, Diehl AJ, Bass A, Wong KK, Rustgi AK, Nakagawa H. (2017). Interplay between Notch1 and Notch3 promotes EMT, tumor initiation and cancer cell heterogeneity in squamous cell carcinoma. Nature Communications 8 (1), 1758. (Published).
• Giroux V, Lento AA, Kharbanda A, Hamilton KE, Whelan KA, Long A, Rhoades B, Nakagawa H, Wileyto EP, Klein-Szanto AJ, Wang TC, Rustgi AK. (2017). Long-lived Keratin 15 + esophageal progenitor cells contribute to homeostasis and regeneration. Journal of Clinical Investigation 127 (6), 2378-2391. (Published).
• Giroux V., Rustgi AK. (2017). Metaplasia: tissue injury adaptation and precursor to the dysplasia-cancer sequence. Nature Reviews Cancer 17 (10), 594-604. (Published).
• Hamilton KE, Chatterji P, Lundsmith ET, Andres SF, Giroux V, Hicks PD, Noubissi FK, Spiegelman VS, Rustgi AK. (2015). Loss of stromal Imp1 promotes a tumorigenic microenvironment in the colon. Molecular Cancer Research 13 (11), 1478-1486. (Published).
• Long A, Giroux V, Whelan KA, Hamilton KE, Tétreaul MP, Tanaka K, Lee JS, Klein-Szanto AJ, Nakagawa K, Rustgi AK. (2015). WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Carcinogenesis 36 (5), 598-606. (Published).
• Vega ME, Giroux V, Natsuizaka M, Liu M, Klein-Szanto AJ, Stairs DB, Nakagawa H, Wang KK, Want TC, Lynch JP, Rustgi AK. (2014). Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. Cell Cycle 13 (24), 3857-66. (Published).
• Groulx JF, Giroux V, Beauséjour M, Boudjadi S, Basora N, Carrier JC, Beaulieu JF. (2014). Integrin alpha6A splice variant regulated proliferation and the Wnt/beta-catenin pathway in human colorectal cancer cells. Carcinogenesis 35 (6), 1217-27. (Published).
• Bernatchez G, Giroux V, Lassalle T, Carpentier AC, Rivard N, Carrier JC. (2013). ERRalpha metabolic nuclear receptor controls growth of colon cancer cells. Carcinogenesis 34 (10), 2253-61. (Published).
• Giroux V , Bernatchez G , Carrier JC. (2011). Chemopreventive effect of ERβ-Selective agonist on intestinal tumorigenesis in Apc(Min/+) mice. Molecular carcinogenesis 50 (5), 359-69. (Published).
• Giroux V , Lemay F , Bernatchez G , Robitaille Y , Carrier JC. (2008). Estrogen receptor beta deficiency enhances small intestinal tumorigenesis in ApcMin/+ mice. International journal of cancer. Journal international du cancer 123 (2), 303-11. (Published).

Autres contributions

Cours enseignés

• Undergraduate Student Scholars Program Lectures. (2017-08-03 à 2017-08-03).
• Molecular and Cell Biology Laboratory. (2007-10-08 à 2012-04-13).

Gestion d'évènements

• Poster Judge. (2017) Biomedical Postdoc Symposium. (Conference).
• Co-Director. (2016) 3D organoids in GI tract, Liver and Pancreas. (Workshop).
• Session Chair. (2012) 11th Annual Research Topics in GI Disease Meeting. (Conference).

Présentations

• (2018). Identification of radio-resistant and tumor-initiating Keratin 15+ cells in the digestive epithelium. Centre de Recherche du CHUM - Université de Montréal. Canada
• (2018). Keratin15 marks stem cells with radio-resistant and tumor-initiating capacities in the digestive tract. McGill University – Department of Pharmacology & Therapeutics. Canada
• (2017). Identification and characterization of a novel long-lived progenitor cell population in the mouse squamous esophagus. Endoderm: Development, Disease and Regeneration. United States
• (2017). Identification of Keratin 15 (Krt15)+ stem cells in the digestive tract: Implication in tumor initiation and radiation-induced inflammation. Université de Sherbrooke (Department of Anatomy & Cell Biology). Canada
• (2017). Identification of Keratin 15+ radio-resistant and tumor-initiating stem cells in the digestive tract. Centre de Recherche du CHU de Québec (Oncology Axis) - Université Laval. Canada
• (2017). Investigating the role of mutant p53 in esophageal squamous cell carcinoma. AACR Annual Meeting. United States
• (2017). Keratin 15 (Krt15)+ cells are radio-resistant and tumor-initiating cells in the mouse small intestine. AACR Annual Meeting. United States
• (2017). Keratin 15 (Krt15) marks stem cells in the digestive tract harboring radio-resistant and tumor-initiating capacities. University of Guelph. Canada
• (2016). Direct regulation of crypt autophagy and intestinal homeostasis via mRNA binding protein Imp1. Digestive Disease Week. United States
• (2016). Esophageal epithelial autophagy flux regulates eosinophilic esophagitis disease activity. Digestive Disease Week. United States
• (2016). Krt15 marks a long-lived progenitor cell population in the esophageal epithelium. Penn Postdoctoral Fellow Symposium. United States
• (2015). Keratin 15 (K15) annotates a subpopulation of basal cells in the esophageal epithelium. Department of Medicine Research Day. United States
• (2015). Models of Esophageal Diseases: 3D Organoids. Think Tank on Advancing Esophageal Cancer Research. United States
• (2015). Mutant p53 can drive cancer initiation and progression through gain-of-function properties. Academy of Clinical Laboratory Physicians and Scientists Annual Meeting. United States
• (2015). Novel regulation of autophagy and intestinal homeostasis via mRNA binding protein IMP1. Crohn's and Colitis Foundation Annual Meeting. United States
• (2015). WNT10A promotes a more invasive and self-renewing phenotype in esophageal squamous cell carcinoma. Digestive Disease Week 2015. United States
• (2014). Keratin 15 annotates a unique population in esophageal squamous epithelium. 13th Annual Biomedical Postdoctoral Research Symposium. United States
• (2014). Keratin 15 annotates a unique population in the esophageal squamous epithelium. ISSCR Annual Meeting. Canada
• (2014). Loss of mRNA binding protein Imp1 in intestinal epithelium alters autophagy in vivo. Crohn's and Colitis Foundation (CCFA) Annual Meeting. United States
• (2012). Alternative splicing of the metabolic regulator ERRalpha in colon carcinogenesis. AACR Annual Meeting. United States
• (2012). New role for the metabolic regulator ERRalpha in colon carcinogenesis. Keystone Symposia - Cancer & Metabolism. Canada
• (2012). The estrogen receptors superfamily and their roles in intestinal pathologies. University of Pennsylvania. United States
• (2012). The estrogen receptors superfamily and their roles in intestinal pathologies. Columbia University. United States
• (2012). The integrin alpha6A splice variant regulates colon cancer cell proliferation and the Wnt/beta-catenin pathway. AACR Annual Meeting. United States
• (2012). The metabolic regulator ERRalpha and its splice variant regulate colorectal carcinogenesis. 11th Annual Research Topics in GI Disease Meeting. Canada
• (2012). The metabolic regulator ERRalpha and its splice variant regulate colorectal carcinogenesis. Canadian Digestive Disease Week. Canada
• (2011). Effect of deficiency for estrogen-related receptor alpha in a colon carcinogenesis model. 1st International Symposium on the Physiology and Diseases of the Digestive Tract. Canada
• (2011). Intriguing role for estrogen-related receptor alpha in colorectal cancer. 1st International Symposium on the Physiology and Diseases of the Digestive Tract. Canada
• (2011). Intriguing role for estrogen-related receptor alpha in colorectal cancer. AACR Annual Meeting. United States
• (2011). Rôles d'une déficience pour le récepteur relié à l'oestrogène alpha dans un modèle murin de carcinogenèse colique. CRCQ Annual Meeting. Canada
• (2011). Rôles du récepteur relié à l'oestrogène dans des modèles murins de carcinogenèse colique. ACFAS Annual Meeting. Canada
• (2010). Absence d'un variant d'épissage du récepteur nucléaire ERRalpha dans le cancer colorectal. CRCQ Annual Meeting. Canada
• (2010). ERbeta specific activation reduces intestinal inflammation: implication of TGFbeta pathway. Keystone Symposia - Nuclear Receptors: signaling, gene regulation and cancer. United States
• (2010). L'oestrogène, modulateur des maladies inflammatoires intestinales. Conférence de la Relève - Gilles Dupuis. Canada
• (2010). Regulation of colon cancer cell proliferation by the estrogen-related receptor alpha. 15th World Congress on Advances in Oncology. Greece
• (2009). Estrogen receptor beta activation reduces intestinal inflammation in DSS-induced colitis murine model. Digestive Disease Week. United States
• (2009). L'activation du récepteur à l'oestrogène beta (ERb) réduit l'inflammation intestinale: implication de la voie du TGFbeta. CRCQ Annual Meeting. Canada
• (2009). L'activation du récepteur à l'oestrogène beta réduit l'inflammation intestinale. Scientific Day of the Faculty of Medicine of Université de Sherbrooke. Canada
• (2008). Chemopreventive effect of ERbeta specific agonist on intestinal tumorigenesis in APCMin/+ mice. Canadian Digestive Disease Week. Canada
• (2008). Effet chémopréventif d'un agoniste ERbeta dans la tumorigenèse intestinale. Scientific Day of the Faculty of Medicine of the Université de Sherbrooke. Canada
• (2008). Reduction of colon cancer cell growth by estrogen-related receptor alpha. Keystone Symposia - Nuclear Receptors: Orphan Brothers. Canada
• (2008). Role of H2A.Z in the cell cycle and carcinogenesis. Molecular and Cellular Biology 51st Meeting. Canada
• (2008). Rôle chemopréventif de l'oestrogène dans le cancer colorectal: implication de la voie du TGFbeta. 7th Symposium on Physiopathology of the digestive tract. Canada
• (2008). The estrogen-related receptor alpha (ERRa) promotes cell proliferation in DLD-1 colorectal cancer cell line. Canadian Digestive Disease Week. Canada
• (2007). Chemopreventive effect of ERbeta agonist on intestinal tumorigenesis in APCmin mice. AACR Conference on Advances in colon research. United States
• (2007). Effet chémopréventif d'un agoniste d'ER beta dans la tumorigenèse intestinale. CRCQ Annual Meeting. Canada
• (2007). Effet chémopréventif d'un agoniste du récepteur oestrogénique beta dans la tumorigenèse intestinale : implication de la voie du TGF beta. 6th Symposium of Physiopathology of the digestive tract. Canada
• (2007). Le récepteur-relié à l'oestrogène alpha (ERR alpha) et son avantage proliférait dans le cancer du côlon. CRCQ Annual Meeting. Canada
• (2007). Protective role of estrogen in colorectal cancer: positive regulation of TGFbeta pathway. 3rd International Symposium on Pediatric Gastroenterology, Hepatology and Nutrition. Canada
• (2007). Roles of H2A.Z in gene expression during cell cycle and carcinogenesis. 10th Meeting - Mechanisms of eukaryotic regulation,. United States
• (2006). Effet protecteur de l'oestrogène dans le cancer du côlon via ERbeta: modulation de la voie du TGFbeta. CRCQ Annual Meeting. Canada
• (2005). BMP signaling regulates intestinal maintenance, proliferation and cell fate. Digestive Disease Week. United States
• (2005). Implication de la voie BMP dans la régulation du maintien de l'intégrité tissulaire, de la prolifération et de détermination cellulaire au niveau de l'épithélium intestinal. ACFAS Annual Meeting. Canada
• (2005). Implication de la voie BMP dans la régulation du maintien de l'intégrité épithéliale intestinale. 4th Symposium of Physiopathology of the digestive tract. Canada
• (2005). Rôle de la voie de signalisation de BMP dans la détermination du phénotype cellulaire endocrinien au niveau de l'épithélium intestinal. CRCQ Annual Meeting. Canada
• (2004). Caractérisation de la voie de signalisation de BMP dans l'épithélium de l'intestin grêle. CRCQ Annual Meeting. Canada